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I6THZ2

- I6THZ2_ENCHA

UniProt

I6THZ2 - I6THZ2_ENCHA

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Protein
DNA ligase
Gene
EHEL_021150
Organism
Encephalitozoon hellem (strain ATCC 50504) (Microsporidian parasite)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-KW
  3. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:EHEL_021150Imported
OrganismiEncephalitozoon hellem (strain ATCC 50504) (Microsporidian parasite)Imported
Taxonomic identifieri907965 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000010086: Chromosome II

Organism-specific databases

EuPathDBiMicrosporidiaDB:EHEL_021150.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I6THZ2-1 [UniParc]FASTAAdd to Basket

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MSKILFSDFC ATLEKINLTT KRLEIQSILT DYLKEVCKTH PQSLAPALYL    50
STGMVYPEYF NKELGVGENM LVSVVAEFTG KSIKNIRSEY SKVGDLGTIA 100
MKCRVSQLFI PKTQLEVMDV FLGMRRIVGE EGPKSSSSKK RIILGMMVKC 150
SPLESKYLVR LIEGRLKIGL ALKTVLISLG NVFSSDKADE IKAAFNRQPD 200
IGRLAECILD HGMENLAVRF QVTPGIPLKP MLANPSKDLT SAFKRVENKS 250
FACEYKYDGE RVQIHKFGSS IETFSRNSEK TTEKYPDLMD LYNISDKDFI 300
IDGEIVAYDR REGKILPFQV LTTRKRKRVE SSKIDVHVCV FAFDLIYFDG 350
KAYIDEVLEE RRRVLHSSFR EVEGRFQFAE FRDCETPEDA ETFFSTSVEK 400
GFEGIMVKTL GPDTTYLPSQ RSNKWIKIKK DYLESMSDSL DLVVMGAYYG 450
KGKRTGFYGG FLLGVYNDEE EKFEALCKIG TGFDDSILSK LYEQLSSNLC 500
SAPKNYSYKE SVKPDVWVEA KYVWEVRAAG MSLSPIYNAG GSRNGKGISL 550
RFPRFIRERD DKGVKEATTS SQVYQMYLDS KVENSEEFY 589
Length:589
Mass (Da):66,940
Last modified:October 3, 2012 - v1
Checksum:iBABF72922935368E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002714 Genomic DNA. Translation: AFM97869.1.
RefSeqiXP_003886850.1. XM_003886801.1.

Genome annotation databases

GeneIDi13467568.
KEGGiehe:EHEL_021150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002714 Genomic DNA. Translation: AFM97869.1 .
RefSeqi XP_003886850.1. XM_003886801.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 13467568.
KEGGi ehe:EHEL_021150.

Organism-specific databases

EuPathDBi MicrosporidiaDB:EHEL_021150.

Phylogenomic databases

KOi K10747.
OrthoDBi EOG7TXKRG.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gain and loss of multiple functionally related, horizontally transferred genes in the reduced genomes of two microsporidian parasites."
    Pombert J.-F., Selman M., Burki F., Bardell F.T., Farinelli L., Solter L.F., Whitman D.W., Weiss L.M., Corradi N., Keeling P.J.
    Proc. Natl. Acad. Sci. U.S.A. 109:12638-12643(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 50504Imported.

Entry informationi

Entry nameiI6THZ2_ENCHA
AccessioniPrimary (citable) accession number: I6THZ2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: April 16, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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