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I6THZ2

- I6THZ2_ENCHA

UniProt

I6THZ2 - I6THZ2_ENCHA

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Protein

DNA ligase

Gene

EHEL_021150

Organism
Encephalitozoon hellem (strain ATCC 50504) (Microsporidian parasite)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:EHEL_021150Imported
OrganismiEncephalitozoon hellem (strain ATCC 50504) (Microsporidian parasite)Imported
Taxonomic identifieri907965 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000010086: Chromosome II

Organism-specific databases

EuPathDBiMicrosporidiaDB:EHEL_021150.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I6THZ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKILFSDFC ATLEKINLTT KRLEIQSILT DYLKEVCKTH PQSLAPALYL
60 70 80 90 100
STGMVYPEYF NKELGVGENM LVSVVAEFTG KSIKNIRSEY SKVGDLGTIA
110 120 130 140 150
MKCRVSQLFI PKTQLEVMDV FLGMRRIVGE EGPKSSSSKK RIILGMMVKC
160 170 180 190 200
SPLESKYLVR LIEGRLKIGL ALKTVLISLG NVFSSDKADE IKAAFNRQPD
210 220 230 240 250
IGRLAECILD HGMENLAVRF QVTPGIPLKP MLANPSKDLT SAFKRVENKS
260 270 280 290 300
FACEYKYDGE RVQIHKFGSS IETFSRNSEK TTEKYPDLMD LYNISDKDFI
310 320 330 340 350
IDGEIVAYDR REGKILPFQV LTTRKRKRVE SSKIDVHVCV FAFDLIYFDG
360 370 380 390 400
KAYIDEVLEE RRRVLHSSFR EVEGRFQFAE FRDCETPEDA ETFFSTSVEK
410 420 430 440 450
GFEGIMVKTL GPDTTYLPSQ RSNKWIKIKK DYLESMSDSL DLVVMGAYYG
460 470 480 490 500
KGKRTGFYGG FLLGVYNDEE EKFEALCKIG TGFDDSILSK LYEQLSSNLC
510 520 530 540 550
SAPKNYSYKE SVKPDVWVEA KYVWEVRAAG MSLSPIYNAG GSRNGKGISL
560 570 580
RFPRFIRERD DKGVKEATTS SQVYQMYLDS KVENSEEFY
Length:589
Mass (Da):66,940
Last modified:October 3, 2012 - v1
Checksum:iBABF72922935368E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002714 Genomic DNA. Translation: AFM97869.1.
RefSeqiXP_003886850.1. XM_003886801.1.

Genome annotation databases

GeneIDi13467568.
KEGGiehe:EHEL_021150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002714 Genomic DNA. Translation: AFM97869.1 .
RefSeqi XP_003886850.1. XM_003886801.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 13467568.
KEGGi ehe:EHEL_021150.

Organism-specific databases

EuPathDBi MicrosporidiaDB:EHEL_021150.

Phylogenomic databases

KOi K10747.
OrthoDBi EOG7TXKRG.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gain and loss of multiple functionally related, horizontally transferred genes in the reduced genomes of two microsporidian parasites."
    Pombert J.-F., Selman M., Burki F., Bardell F.T., Farinelli L., Solter L.F., Whitman D.W., Weiss L.M., Corradi N., Keeling P.J.
    Proc. Natl. Acad. Sci. U.S.A. 109:12638-12643(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 50504Imported.

Entry informationi

Entry nameiI6THZ2_ENCHA
AccessioniPrimary (citable) accession number: I6THZ2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3