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I6T946

- I6T946_ENTHA

UniProt

I6T946 - I6T946_ENTHA

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Protein

Alanine racemase

Gene
EHR_03895, I584_02147, UAE_00199
Organism
Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei140 – 1401Substrate By similarityUniRule annotation
Active sitei268 – 2681Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei315 – 3151Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciEHIR768486:GLCW-762-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:EHR_03895Imported
ORF Names:I584_02147Imported, UAE_00199Imported
OrganismiEnterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)Imported
Taxonomic identifieri768486 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000002895: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I6T946-1 [UniParc]FASTAAdd to Basket

« Hide

MVVAWHRPTR VIIHTKAITE NVKKELARLP KGKELFAVVK ANGYGHGAVQ    50
TAEAALAGGA TGFCVSNLDE GIELREAGFT QPILVLNMIP IDALTLAVVH 100
DLSITVGNKE WLEQAVEYLQ ERKLKHALAL HLKVDTGMGR IGFLTPEEVV 150
EAVSFIQESA VLEWEGIFTH FSTADQADET YWQQQHQRFI ETIDALPALP 200
KYVHVSNSAT ALWHDEKIGN MIRFGVAMYG LNPSGHALPE PYPLEPALEL 250
VSELIQVKRL AKGEGIGYGE TYITDQPEWI GTIPIGYADG WLRNMQGFSV 300
LVDGNLCEIV GRVCMDQIMI RLPQEVPLGT KVTLIGKNQE KEISMQAVAD 350
QLGTIHYEVA CVLGTRIPRE YEE 373
Length:373
Mass (Da):41,301
Last modified:October 3, 2012 - v1
Checksum:i333FA7B3BD5A2C24
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003504 Genomic DNA. Translation: AFM69749.1.
AJAI01000002 Genomic DNA. Translation: EOH73633.1.
ASVZ01000003 Genomic DNA. Translation: EOU04161.1.
RefSeqiYP_006486640.1. NC_018081.1.

Genome annotation databases

EnsemblBacteriaiAFM69749; AFM69749; EHR_03895.
EOH73633; EOH73633; UAE_00199.
EOU04161; EOU04161; I584_02147.
GeneIDi13178654.
KEGGiehr:EHR_03895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003504 Genomic DNA. Translation: AFM69749.1 .
AJAI01000002 Genomic DNA. Translation: EOH73633.1 .
ASVZ01000003 Genomic DNA. Translation: EOU04161.1 .
RefSeqi YP_006486640.1. NC_018081.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFM69749 ; AFM69749 ; EHR_03895 .
EOH73633 ; EOH73633 ; UAE_00199 .
EOU04161 ; EOU04161 ; I584_02147 .
GeneIDi 13178654.
KEGGi ehr:EHR_03895.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci EHIR768486:GLCW-762-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790, a model organism for the study of ion transport, bioenergetics, and copper homeostasis."
    Gaechter T., Wunderlin C., Schmidheini T., Solioz M.
    J. Bacteriol. 194:5126-5127(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9790Imported and ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 9790Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 9790Imported.

Entry informationi

Entry nameiI6T946_ENTHA
AccessioniPrimary (citable) accession number: I6T946
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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