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I6T946

- I6T946_ENTHA

UniProt

I6T946 - I6T946_ENTHA

Protein

Alanine racemase

Gene

EHR_03895

Organism
Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (03 Oct 2012)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei140 – 1401SubstrateUniRule annotation
    Active sitei268 – 2681Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei315 – 3151Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciEHIR768486:GLCW-762-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:EHR_03895Imported
    ORF Names:I584_02147Imported, UAE_00199Imported
    OrganismiEnterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)Imported
    Taxonomic identifieri768486 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
    ProteomesiUP000002895: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I6T946-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVAWHRPTR VIIHTKAITE NVKKELARLP KGKELFAVVK ANGYGHGAVQ    50
    TAEAALAGGA TGFCVSNLDE GIELREAGFT QPILVLNMIP IDALTLAVVH 100
    DLSITVGNKE WLEQAVEYLQ ERKLKHALAL HLKVDTGMGR IGFLTPEEVV 150
    EAVSFIQESA VLEWEGIFTH FSTADQADET YWQQQHQRFI ETIDALPALP 200
    KYVHVSNSAT ALWHDEKIGN MIRFGVAMYG LNPSGHALPE PYPLEPALEL 250
    VSELIQVKRL AKGEGIGYGE TYITDQPEWI GTIPIGYADG WLRNMQGFSV 300
    LVDGNLCEIV GRVCMDQIMI RLPQEVPLGT KVTLIGKNQE KEISMQAVAD 350
    QLGTIHYEVA CVLGTRIPRE YEE 373
    Length:373
    Mass (Da):41,301
    Last modified:October 3, 2012 - v1
    Checksum:i333FA7B3BD5A2C24
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003504 Genomic DNA. Translation: AFM69749.1.
    AJAI01000002 Genomic DNA. Translation: EOH73633.1.
    ASVZ01000003 Genomic DNA. Translation: EOU04161.1.
    RefSeqiYP_006486640.1. NC_018081.1.

    Genome annotation databases

    EnsemblBacteriaiAFM69749; AFM69749; EHR_03895.
    EOH73633; EOH73633; UAE_00199.
    EOU04161; EOU04161; I584_02147.
    GeneIDi13178654.
    KEGGiehr:EHR_03895.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003504 Genomic DNA. Translation: AFM69749.1 .
    AJAI01000002 Genomic DNA. Translation: EOH73633.1 .
    ASVZ01000003 Genomic DNA. Translation: EOU04161.1 .
    RefSeqi YP_006486640.1. NC_018081.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFM69749 ; AFM69749 ; EHR_03895 .
    EOH73633 ; EOH73633 ; UAE_00199 .
    EOU04161 ; EOU04161 ; I584_02147 .
    GeneIDi 13178654.
    KEGGi ehr:EHR_03895.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci EHIR768486:GLCW-762-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790, a model organism for the study of ion transport, bioenergetics, and copper homeostasis."
      Gaechter T., Wunderlin C., Schmidheini T., Solioz M.
      J. Bacteriol. 194:5126-5127(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 9790Imported and ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ATCC 9790Imported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ATCC 9790Imported.

    Entry informationi

    Entry nameiI6T946_ENTHA
    AccessioniPrimary (citable) accession number: I6T946
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 3, 2012
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3