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I6T946 (I6T946_ENTHA) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. SAAS SAAS009006 RuleBase RU004247 HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. SAAS SAAS009006 HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. RuleBase RU004247 HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family. RuleBase RU004188 HAMAP-Rule MF_01201

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site401Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2681Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1401Substrate By similarity HAMAP-Rule MF_01201
Binding site3151Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue401N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
I6T946 [UniParc].

Last modified October 3, 2012. Version 1.
Checksum: 333FA7B3BD5A2C24

FASTA37341,301
        10         20         30         40         50         60 
MVVAWHRPTR VIIHTKAITE NVKKELARLP KGKELFAVVK ANGYGHGAVQ TAEAALAGGA 

        70         80         90        100        110        120 
TGFCVSNLDE GIELREAGFT QPILVLNMIP IDALTLAVVH DLSITVGNKE WLEQAVEYLQ 

       130        140        150        160        170        180 
ERKLKHALAL HLKVDTGMGR IGFLTPEEVV EAVSFIQESA VLEWEGIFTH FSTADQADET 

       190        200        210        220        230        240 
YWQQQHQRFI ETIDALPALP KYVHVSNSAT ALWHDEKIGN MIRFGVAMYG LNPSGHALPE 

       250        260        270        280        290        300 
PYPLEPALEL VSELIQVKRL AKGEGIGYGE TYITDQPEWI GTIPIGYADG WLRNMQGFSV 

       310        320        330        340        350        360 
LVDGNLCEIV GRVCMDQIMI RLPQEVPLGT KVTLIGKNQE KEISMQAVAD QLGTIHYEVA 

       370 
CVLGTRIPRE YEE 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790, a model organism for the study of ion transport, bioenergetics, and copper homeostasis."
Gaechter T., Wunderlin C., Schmidheini T., Solioz M.
J. Bacteriol. 194:5126-5127(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 9790 EMBL AFM69749.1 and ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.
[2]"The Genome Sequence of Enterococcus hirae ATCC_8043."
The Broad Institute Genome Sequencing Platform, The Broad Institute Genome Sequencing Center for Infectious Disease
Earl A.M., Gilmore M.S., Lebreton F., Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A., Gujja S. expand/collapse author list , Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.
Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: ATCC 9790 EMBL EOH73633.1.
[3]"The Genome Sequence of Enterococcus hirae ATCC_8043 (PacBio/Illumina hybrid assembly)."
The Broad Institute Genomics Platform, The Broad Institute Genome Sequencing Center for Infectious Disease
Earl A., Russ C., Gilmore M., Surin D., Walker B., Young S., Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J. expand/collapse author list , Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.
Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: ATCC 9790 EMBL EOU04161.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003504 Genomic DNA. Translation: AFM69749.1.
AJAI01000002 Genomic DNA. Translation: EOH73633.1.
ASVZ01000003 Genomic DNA. Translation: EOU04161.1.
RefSeqYP_006486640.1. NC_018081.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFM69749; AFM69749; EHR_03895.
EOH73633; EOH73633; UAE_00199.
GeneID13178654.
KEGGehr:EHR_03895.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01775.

Enzyme and pathway databases

BioCycEHIR768486:GLCW-762-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI6T946_ENTHA
AccessionPrimary (citable) accession number: I6T946
Entry history
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: April 16, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)