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I6T946

- I6T946_ENTHA

UniProt

I6T946 - I6T946_ENTHA

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Protein

Alanine racemase

Gene

EHR_03895

Organism
Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei140 – 1401SubstrateUniRule annotation
Active sitei268 – 2681Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei315 – 3151Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciEHIR768486:GLCW-762-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:EHR_03895Imported
ORF Names:I584_02147Imported, UAE_00199Imported
OrganismiEnterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)Imported
Taxonomic identifieri768486 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000002895: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI6T946.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I6T946-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVVAWHRPTR VIIHTKAITE NVKKELARLP KGKELFAVVK ANGYGHGAVQ
60 70 80 90 100
TAEAALAGGA TGFCVSNLDE GIELREAGFT QPILVLNMIP IDALTLAVVH
110 120 130 140 150
DLSITVGNKE WLEQAVEYLQ ERKLKHALAL HLKVDTGMGR IGFLTPEEVV
160 170 180 190 200
EAVSFIQESA VLEWEGIFTH FSTADQADET YWQQQHQRFI ETIDALPALP
210 220 230 240 250
KYVHVSNSAT ALWHDEKIGN MIRFGVAMYG LNPSGHALPE PYPLEPALEL
260 270 280 290 300
VSELIQVKRL AKGEGIGYGE TYITDQPEWI GTIPIGYADG WLRNMQGFSV
310 320 330 340 350
LVDGNLCEIV GRVCMDQIMI RLPQEVPLGT KVTLIGKNQE KEISMQAVAD
360 370
QLGTIHYEVA CVLGTRIPRE YEE
Length:373
Mass (Da):41,301
Last modified:October 3, 2012 - v1
Checksum:i333FA7B3BD5A2C24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003504 Genomic DNA. Translation: AFM69749.1.
AJAI01000002 Genomic DNA. Translation: EOH73633.1.
ASVZ01000003 Genomic DNA. Translation: EOU04161.1.
RefSeqiYP_006486640.1. NC_018081.1.

Genome annotation databases

EnsemblBacteriaiAFM69749; AFM69749; EHR_03895.
EOH73633; EOH73633; UAE_00199.
EOU04161; EOU04161; I584_02147.
GeneIDi13178654.
KEGGiehr:EHR_03895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003504 Genomic DNA. Translation: AFM69749.1 .
AJAI01000002 Genomic DNA. Translation: EOH73633.1 .
ASVZ01000003 Genomic DNA. Translation: EOU04161.1 .
RefSeqi YP_006486640.1. NC_018081.1.

3D structure databases

ProteinModelPortali I6T946.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFM69749 ; AFM69749 ; EHR_03895 .
EOH73633 ; EOH73633 ; UAE_00199 .
EOU04161 ; EOU04161 ; I584_02147 .
GeneIDi 13178654.
KEGGi ehr:EHR_03895.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci EHIR768486:GLCW-762-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790, a model organism for the study of ion transport, bioenergetics, and copper homeostasis."
    Gaechter T., Wunderlin C., Schmidheini T., Solioz M.
    J. Bacteriol. 194:5126-5127(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9790Imported and ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 9790Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 9790Imported.

Entry informationi

Entry nameiI6T946_ENTHA
AccessioniPrimary (citable) accession number: I6T946
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: November 26, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3