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I6T1F7 (I6T1F7_ENTHA) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 6. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphofructokinase HAMAP-Rule MF_00339
Short name=Phosphofructokinase HAMAP-Rule MF_00339
EC=2.7.1.11 HAMAP-Rule MF_00339
Alternative name(s):
Phosphohexokinase HAMAP-Rule MF_00339
Gene names
Name:pfkA HAMAP-Rule MF_00339
Ordered Locus Names:EHR_14015 EMBL AFM71652.1
OrganismEnterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258) [Complete proteome] [HAMAP] EMBL AFM71652.1
Taxonomic identifier768486 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Enterococcaceae › Enterococcus ›

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. HAMAP-Rule MF_00339

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. HAMAP-Rule MF_00339 SAAS SAAS012828

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00339.

Sequence similarities

Belongs to the phosphofructokinase family. HAMAP-Rule MF_00339

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding21 – 255ATP By similarity HAMAP-Rule MF_00339
Nucleotide binding154 – 1585ATP By similarity HAMAP-Rule MF_00339
Nucleotide binding171 – 18717ATP By similarity HAMAP-Rule MF_00339

Sites

Active site1271Proton acceptor By similarity HAMAP-Rule MF_00339
Metal binding1851Magnesium; via carbonyl oxygen By similarity HAMAP-Rule MF_00339
Metal binding1871Magnesium By similarity HAMAP-Rule MF_00339
Binding site1621Substrate By similarity HAMAP-Rule MF_00339
Binding site2431Substrate By similarity HAMAP-Rule MF_00339
Binding site2491Substrate By similarity HAMAP-Rule MF_00339
Binding site2521Substrate By similarity HAMAP-Rule MF_00339

Sequences

Sequence LengthMass (Da)Tools
I6T1F7 [UniParc].

Last modified October 3, 2012. Version 1.
Checksum: 6FCD34771774AFE2

FASTA32034,236
        10         20         30         40         50         60 
MKRIGILTSG GDAPGMNAAI RAVVRKGIYE GLEVYGINYG FAGLVAGDIR RLDVADVGDK 

        70         80         90        100        110        120 
IQRGGTFLYS ARYPEFATEE GQLKGIEQLK KFGIEGLVVI GGDGSYHGAM ALTRRGFPAV 

       130        140        150        160        170        180 
GVPGTIDNDI PGTDFTIGFD TAINTVLESI DRIRDTATSH VRTFVIEVMG RNAGDIALWS 

       190        200        210        220        230        240 
GVAGGADEII IPEHDFDMAS VAKKIQEGRD RGKKHCLIIL AEGVMGGNEF AEKLSEYGDY 

       250        260        270        280        290        300 
HTRVSILGHV VRGGSPSARD RVLASKFGAY AVDLLRAGKG GLCVGIRDNE MVAADIIETL 

       310        320 
ESNKHKPDLS LYDLNNSLSF

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References

[1]"Genome Sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790, a Model Organism for the Study of Ion Transport, Bioenergetics, and Copper Homeostasis."
Gaechter T., Wunderlin C., Schmidheini T., Solioz M.
J. Bacteriol. 194:5126-5127(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003504 Genomic DNA. Translation: AFM71652.1.
RefSeqYP_006488543.1. NC_018081.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFM71652; AFM71652; EHR_14015.
GeneID13176784.
KEGGehr:EHR_14015.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00850.

Enzyme and pathway databases

UniPathwayUPA00109; UER00182.

Family and domain databases

HAMAPMF_00339. Phosphofructokinase.
InterProIPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamPF00365. PFK. 1 hit.
[Graphical view]
PIRSFPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSPR00476. PHFRCTKINASE.
SUPFAMSSF53784. Ppfruckinase. 1 hit.
TIGRFAMsTIGR02482. PFKA_ATP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameI6T1F7_ENTHA
AccessionPrimary (citable) accession number: I6T1F7
Entry history
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: April 3, 2013
This is version 6 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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