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I6R4E5

- I6R4E5_MYCTX

UniProt

I6R4E5 - I6R4E5_MYCTX

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Protein

Glutamate decarboxylase

Gene

TBXG_003454

Organism
Mycobacterium tuberculosis KZN 605
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciMTUB478435:GLGX-3569-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
ORF Names:TBXG_003454Imported
OrganismiMycobacterium tuberculosis KZN 605Imported
Taxonomic identifieri478435 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000002898: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiI6R4E5.

Structurei

3D structure databases

ProteinModelPortaliI6R4E5.
SMRiI6R4E5. Positions 12-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

KOiK01580.
OMAiPTFQINF.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

I6R4E5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRSHPSVPA HSIAPAYTGR MFTAPVPALR MPDESMDPEA AYRFIHDELM
60 70 80 90 100
LDGSSRLNLA TFVTTWMDPE AEKLMAETFD KNMIDKDEYP ATAAIEARCV
110 120 130 140 150
SMVADLFHAE GLRDHDPTSA TGVSTIGSSE AVMLGGLALK WRWRQRVGSW
160 170 180 190 200
KGRMPNLVMG SNVQVVWEKF CRYFDVEPRY LPMERGRYVI TPEQVLAAVD
210 220 230 240 250
ENTIGVVAIL GTTYTGELEP IAEICAALDK LAAGGGVDVP VHVDAASGGF
260 270 280 290 300
VVPFLHPDLV WDFRLPRVVS INVSGHKYGL TYPGVGFVVW RGPEHLPEDL
310 320 330 340 350
VFRVNYLGGD MPTFTLNFSR PGNQVVGQYY NFLRLGRDGY TKVMQALSHT
360 370 380 390 400
ARWLGDQLRE VDHCEVISDG SAIPVVSFRL AGDRGYTEFD VSHELRTFGW
410 420 430 440 450
QVPAYTMPDN ATDVAVLRIV VREGLSADLA RALHDDAVTA LAALDKVKPG
460
GHFDAQHFAH
Length:460
Mass (Da):50,780
Last modified:October 3, 2012 - v1
Checksum:iB5DA3156D4C7CB4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001976 Genomic DNA. Translation: AFM50882.1.
RefSeqiYP_006474959.1. NC_018078.1.

Genome annotation databases

EnsemblBacteriaiAFM50882; AFM50882; TBXG_003454.
GeneIDi13160674.
KEGGimtz:TBXG_003454.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001976 Genomic DNA. Translation: AFM50882.1 .
RefSeqi YP_006474959.1. NC_018078.1.

3D structure databases

ProteinModelPortali I6R4E5.
SMRi I6R4E5. Positions 12-447.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi I6R4E5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFM50882 ; AFM50882 ; TBXG_003454 .
GeneIDi 13160674.
KEGGi mtz:TBXG_003454.

Phylogenomic databases

KOi K01580.
OMAi PTFQINF.

Enzyme and pathway databases

BioCyci MTUB478435:GLGX-3569-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
InterProi IPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11999:SF1. PTHR11999:SF1. 1 hit.
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The Genome Sequence of Mycobacterium tuberculosis strain KZN 605."
    The Broad Institute Genome Sequencing Platform, The Broad Institute Genome Sequencing Center for Infectious Disease.
    Galagan J., Murray M., Pillay M., Borowsky M.L., Young S.K., Zeng Q., Koehrsen M., Fitzgerald M., Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Borenstein D., Brown A., Chapman S.B., Chen Z., Dunbar C., Engels R.
    , Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D., Larson L., Lui A., MacDonald J.P., Mehta T., Montmayeur A., Neiman D., Park D., Pearson M., Priest M., Richards J., Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.
    Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: KZN 605Imported.

Entry informationi

Entry nameiI6R4E5_MYCTX
AccessioniPrimary (citable) accession number: I6R4E5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: November 26, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3