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Protein

DNA (cytosine-5)-methyltransferase

Gene

DNMT1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

DNA-bindingUniRule annotation, S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA (cytosine-5)-methyltransferaseUniRule annotation (EC:2.1.1.37UniRule annotation)
Gene namesi
Name:DNMT1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiI6L9H2.
PeptideAtlasiI6L9H2.
PRIDEiI6L9H2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352516.

Structurei

3D structure databases

ProteinModelPortaliI6L9H2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini541 – 58747CXXC-typeInterPro annotationAdd
BLAST
Domaini650 – 775126BAHInterPro annotationAdd
BLAST
Domaini867 – 995129BAHInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IF68. Eukaryota.
COG0270. LUCA.
KOiK00558.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR031303. C5_meth_CS.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR017198. DNMT1_meta.
IPR029063. SAM-dependent_MTases.
IPR002857. Znf_CXXC.
[Graphical view]
PfamiPF01426. BAH. 2 hits.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
PIRSFiPIRSF037404. DNMT1. 1 hit.
PRINTSiPR00105. C5METTRFRASE.
SMARTiSM00439. BAH. 2 hits.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
PS51058. ZF_CXXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I6L9H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADANSPPKP LSKPRTPRRS KSDGEAKRSR DPPASASQVT GIRAEPSPSP
60 70 80 90 100
RITRKSTRQT TITSHFAKGP AKRKPQEESE RAKSDESIKE EDKDQDEKRR
110 120 130 140 150
RVTSRERVAR PLPAEEPERA KSGTRTEKEE ERDEKEEKRL RSQTKEPTPK
160 170 180 190 200
QKLKEEPDRE ARAGVQADED EDGDEKDEKK HRSQPKDLAA KRRPEEKEPE
210 220 230 240 250
KVNPQISDEK DEDEKEEKRR KTTPKEPTEK KMARAKTVMN SKTHPPKCIQ
260 270 280 290 300
CGQYLDDPDL KYGQHPPDAV DEPQMLTNEK LSIFDANESG FESYEALPQH
310 320 330 340 350
KLTCFSVYCK HGHLCPIDTG LIEKNIELFF SGSAKPIYDD DPSLEGGVNG
360 370 380 390 400
KNLGPINEWW ITGFDGGEKA LIGFSTSFAE YILMDPSPEY APIFGLMQEK
410 420 430 440 450
IYISKIVVEF LQSNSDSTYE DLINKIETTV PPSGLNLNRF TEDSLLRHAQ
460 470 480 490 500
FVVEQVESYD EAGDSDEQPI FLTPCMRDLI KLAGVTLGQR RAQARRQTIR
510 520 530 540 550
HSTREKDRGP TKATTTKLVY QIFDTFFAEQ IEKDDREDKE NAFKRRRCGV
560 570 580 590 600
CEVCQQPECG KCKACKDMVK FGGSGRSKQA CQERRCPNMA MKEADDDEEV
610 620 630 640 650
DDNIPEMPSP KKMHQGKKKK QNKNRISWVG EAVKTDGKKS YYKKVCIDAE
660 670 680 690 700
TLEVGDCVSV IPDDSSKPLY LARVTALWED SSNGQMFHAH WFCAGTDTVL
710 720 730 740 750
GATSDPLELF LVDECEDMQL SYIHSKVKVI YKAPSENWAM EGGMDPESLL
760 770 780 790 800
EGDDGKTYFY QLWYDQDYAR FESPPKTQPT EDNKFKFCVS CARLAEMRQK
810 820 830 840 850
EIPRVLEQLE DLDSRVLYYS ATKNGILYRV GDGVYLPPEA FTFNIKLSSP
860 870 880 890 900
VKRPRKEPVD EDLYPEHYRK YSDYIKGSNL DAPEPYRIGR IKEIFCPKKS
910 920 930 940 950
NGRPNETDIK IRVNKFYRPE NTHKSTPASY HADINLLYWS DEEAVVDFKA
960 970 980 990 1000
VQGRCTVEYG EDLPECVQVY SMGGPNRFYF LEAYNAKSKS FEDPPNHARS
1010 1020 1030 1040 1050
PGNKGKGKGK GKGKPKSQAC EPSEPEIEIK LPKLRTLDVF SGCGGLSEGF
1060 1070 1080 1090 1100
HQAGISDTLW AIEMWDPAAQ AFRLNNPGST VFTEDCNILL KLVMAGETTN
1110 1120 1130 1140 1150
SRGQRLPQKG DVEMLCGGPP CQGFSGMNRF NSRTYSKFKN SLVVSFLSYC
1160 1170 1180 1190 1200
DYYRPRFFLL ENVRNFVSFK RSMVLKLTLR CLVRMGYQCT FGVLQAGQYG
1210 1220 1230 1240 1250
VAQTRRRAII LAAAPGEKLP LFPEPLHVFA PRACQLSVVV DDKKFVSNIT
1260 1270 1280 1290 1300
RLSSGPFRTI TVRDTMSDLP EVRNGASALE ISYNGEPQSW FQRQLRGAQY
1310 1320 1330 1340 1350
QPILRDHICK DMSALVAARM RHIPLAPGSD WRDLPNIEVR LSDGTMARKL
1360 1370 1380 1390 1400
RYTHHDRKNG RSSSGALRGV CSCVEAGKAC DPAARQFNTL IPWCLPHTGN
1410 1420 1430 1440 1450
RHNHWAGLYG RLEWDGFFST TVTNPEPMGK QGRVLHPEQH RVVSVRECAR
1460 1470 1480 1490 1500
SQGFPDTYRL FGNILDKHRQ VGNAVPPPLA KAIGLEIKLC MLAKARESAS
1510
AKIKEEEAAK D
Length:1,511
Mass (Da):171,073
Last modified:October 3, 2012 - v1
Checksum:iF4C3F943A4C92DAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092517 mRNA. Translation: AAH92517.1.
RefSeqiNP_001124295.1. NM_001130823.2.
NP_001305659.1. NM_001318730.1.
NP_001305660.1. NM_001318731.1.
NP_001370.1. NM_001379.3.
UniGeneiHs.202672.

Genome annotation databases

GeneIDi1786.
KEGGihsa:1786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC092517 mRNA. Translation: AAH92517.1.
RefSeqiNP_001124295.1. NM_001130823.2.
NP_001305659.1. NM_001318730.1.
NP_001305660.1. NM_001318731.1.
NP_001370.1. NM_001379.3.
UniGeneiHs.202672.

3D structure databases

ProteinModelPortaliI6L9H2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000352516.

Proteomic databases

PaxDbiI6L9H2.
PeptideAtlasiI6L9H2.
PRIDEiI6L9H2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1786.
KEGGihsa:1786.

Organism-specific databases

CTDi1786.

Phylogenomic databases

eggNOGiENOG410IF68. Eukaryota.
COG0270. LUCA.
KOiK00558.

Miscellaneous databases

ChiTaRSiDNMT1. human.
GenomeRNAii1786.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR031303. C5_meth_CS.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR017198. DNMT1_meta.
IPR029063. SAM-dependent_MTases.
IPR002857. Znf_CXXC.
[Graphical view]
PfamiPF01426. BAH. 2 hits.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
PIRSFiPIRSF037404. DNMT1. 1 hit.
PRINTSiPR00105. C5METTRFRASE.
SMARTiSM00439. BAH. 2 hits.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
PS51058. ZF_CXXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LymphImported.

Entry informationi

Entry nameiI6L9H2_HUMAN
AccessioniPrimary (citable) accession number: I6L9H2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: July 6, 2016
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.