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Protein
Submitted name:

NEFL protein

Gene

NEFL

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
NEFL proteinImported
Gene namesi
Name:NEFLImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filamentSAAS annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiI6L9F6.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiI6L9F6. 10 interactors.

Structurei

3D structure databases

ProteinModelPortaliI6L9F6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 88Filament_headInterPro annotationAdd BLAST80

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili94 – 128Sequence analysisAdd BLAST35
Coiled coili136 – 191Sequence analysisAdd BLAST56
Coiled coili219 – 278Sequence analysisAdd BLAST60

Sequence similaritiesi

Belongs to the intermediate filament family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Family and domain databases

InterProiView protein in InterPro
IPR001664. IF.
IPR006821. Intermed_filament_DNA-bd.
IPR027692. NF-L.
PANTHERiPTHR23239. PTHR23239. 1 hit.
PTHR23239:SF242. PTHR23239:SF242. 1 hit.
PfamiView protein in Pfam
PF00038. Filament. 2 hits.
PF04732. Filament_head. 1 hit.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.

Sequencei

Sequence statusi: Complete.

I6L9F6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSFSYEPYY STSYKRRYVE TPRVHISSVR SGYSTARSAY SSYSAPVSSS
60 70 80 90 100
LSVRRSYSSS SGSLMPSLEN LDLSQVAAIS NDLKSIRTQE KAQLQDLNDR
110 120 130 140 150
FASFIERVHE LEQQNKVLEA ELLVLRQKHS EPSRFRALYE QEIRDLRLAA
160 170 180 190 200
EDATNEKQAL QGEREGLEET LRNLQARYEE EVLSREDAEG RLMEARKGAK
210 220 230 240 250
NTDAVRAAKD EVSESRRLLK AKTLEIEACR GMNEALEKQL QELEDKQNAD
260 270 280
ISVMQDTINK LENELRTTKS EMARYLKEYQ DLLT
Length:284
Mass (Da):32,598
Last modified:October 3, 2012 - v1
Checksum:i5664199B9A652AA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066952 mRNA. Translation: AAH66952.1.
UniGeneiHs.521461.

Similar proteinsi

Entry informationi

Entry nameiI6L9F6_HUMAN
AccessioniPrimary (citable) accession number: I6L9F6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: August 30, 2017
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.