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I4IY68

- I4IY68_HUMAN

UniProt

I4IY68 - I4IY68_HUMAN

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Protein
Submitted name:

HLA-C alpha-chain

Gene
HLA-C
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Involved in the presentation of foreign antigens to the immune system By similarity.SAAS annotations

GO - Molecular functioni

  1. peptide antigen binding Source: InterPro

GO - Biological processi

  1. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
  2. immune response Source: InterPro
  3. positive regulation of T cell mediated cytotoxicity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
HLA-C alpha-chainImported
Gene namesi
Name:HLA-CImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. MHC class I protein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC ISAAS annotations

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 PredictedImportedAdd
BLAST
Chaini25 – 366342HLA-C alpha-chainImportedPRO_5000915904Add
BLAST
Chaini25 – 366342 PredictedImportedPRO_5000915903Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotations

Keywords - Domaini

SignalImported, Transmembrane, Transmembrane helixSAAS annotations

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

I4IY68-1 [UniParc]FASTAAdd to Basket

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MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFSTSVSWPG RGEPRFIAVG    50
YVDDTQFVRF DSDAASPRGE PREPWVEQEG PECWDRETQK YKRQAQADRV 100
NLRKLRGYYN QSEDGSHTLQ RMFGCDLGPD GRLLRGYNQF AYDGKDYIAL 150
NEDLRSWTAA DTAAQITQRK WEAAREAEQR RAYLEGTCVE WLRRYLENGK 200
ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQWDGEDQTQ 250
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWKP 300
SSQPTIPIVG IVAGLAVLAV LAVLGAMVAV VMCRRKSSGG KGGSCSQAAS 350
SNSAQGSDES LIACKA 366
Length:366
Mass (Da):40,935
Last modified:September 5, 2012 - v1
Checksum:iFB3BD93FF52C5FC4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE858528 Genomic DNA. Translation: CCI61549.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE858528 Genomic DNA. Translation: CCI61549.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

ChiTaRSi HLA-C. human.
NextBioi 35533845.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Advancing allele group-specific amplification of the complete HLA-C gene--isolation of novel alleles from three allele groups (C*04, C*07 and C*08)."
    Cisneros E., Martinez-Pomar N., Vilches M., Martin P., de Pablo R., Nunez Del Prado N., Nieto A., Matamoros N., Moraru M., Vilches C.
    Tissue Antigens 82:280-285(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiI4IY68_HUMAN
AccessioniPrimary (citable) accession number: I4IY68
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: July 9, 2014
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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