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I4F2H4 (I4F2H4_MODMB) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL CCH89837.1
Ordered Locus Names:MODMU_4453 EMBL CCH89837.1
OrganismModestobacter marinus (strain BC501) [Complete proteome] [HAMAP]
Taxonomic identifier1144889 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeGeodermatophilaceaeModestobacter

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain149 – 366218ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding184 – 23956ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3151Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3331Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3331Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3351Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
I4F2H4 [UniParc].

Last modified September 5, 2012. Version 1.
Checksum: 9C97A59877956160

FASTA37338,831
        10         20         30         40         50         60 
MTGEAGKTRV AVVFGGRSAE HAISCVSAGS VLAALDPERY EVVPVGITRE GGWVLHDGGA 

        70         80         90        100        110        120 
LAIEGGRLPE VTDGTAVSLV GDPAGRGLAV LDPGQAIGRL TEVDVVFPVL HGAHGEDGTI 

       130        140        150        160        170        180 
QGLLEMSGLP YVGSGVFASA ASMDKEFTKK LLSAAGIPQG DHVVLRDASG AICPDPDVLD 

       190        200        210        220        230        240 
EAARERLGLP VFVKPSRAGS SIGITRVTDW AQFPAAVATA AAVDRKVVVE ASVPGREIEC 

       250        260        270        280        290        300 
GVLARPGGGL PEASLPAEIR LRPGTEWYDF DAKYLDDAVE FDVPADLTAE QTAAVQEISR 

       310        320        330        340        350        360 
RAFLAMDCRG LARVDFFLST DPATGADRWV VNEVNTMPGF TPISMFPRMW AATGVSYPEL 

       370 
VDRLVASAGL DGG 

« Hide

References

[1]"Genome sequence of radiation-resistant Modestobacter marinus strain BC501, a representative Actinobacterium that thrives on calcareous stone surfaces."
Normand P., Gury J., Pujic P., Chouaia B., Crotti E., Brusetti L., Daffonchio D., Vacherie B., Barbe V., Medigue C., Calteau A., Ghodhbane-Gtari F., Essoussi I., Nouioui I., Abbassi-Ghozzi I., Gtari M.
J. Bacteriol. 194:4773-4774(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BC501 EMBL CCH89837.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO203431 Genomic DNA. Translation: CCH89837.1.
RefSeqYP_006368301.1. NC_017955.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCH89837; CCH89837; MODMU_4453.
GeneID13008265.
KEGGmmar:MODMU_4453.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycMMAR477641:GLGK-4416-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI4F2H4_MODMB
AccessionPrimary (citable) accession number: I4F2H4
Entry history
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: February 19, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)