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Protein

Probable DNA ligase

Gene

ligB

Organism
Modestobacter marinus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei210ATPUniRule annotation1
Active sitei212N6-AMP-lysine intermediateUniRule annotation1
Binding sitei217ATPUniRule annotation1
Binding sitei232ATPUniRule annotation1
Binding sitei261ATPUniRule annotation1
Binding sitei297ATPUniRule annotation1
Binding sitei373ATPUniRule annotation1
Binding sitei379ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR477641:G1HBM-2195-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligBImported
Synonyms:ligUniRule annotation
Ordered Locus Names:MODMU_2283Imported
OrganismiModestobacter marinusImported
Taxonomic identifieri477641 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaGeodermatophilalesGeodermatophilaceaeModestobacter
Proteomesi
  • UP000006461 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini295 – 413DNA_LIGASE_A3InterPro annotationAdd BLAST119

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747
OrthoDBiPOG091H0BGA

Family and domain databases

Gene3Di1.10.3260.101 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

I4EWF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLADVLAVS AAVSATRSRT AKAQAIADLV RRAGDAEVEP VTAWLSGELR
60 70 80 90 100
QGRLGLGWRT LSRLTGEPAA EPSLTVGALD AALDELATTS GAGSAARRDA
110 120 130 140 150
LVGAVLAAAT ESEQQFLVRL LTGELRQGAL EGVVLDAVAL AADVPAAAVR
160 170 180 190 200
RAFMLSGRLP ETAATALTGG VAALDAVQLQ VGRPVRPMLA SPGSSLDAAL
210 220 230 240 250
TDLGSEVTVE FKLDGARIQV HRDGDVVRVW TRTLREVTDG VPELVDRIRA
260 270 280 290 300
LPCETAVLDG ETLALDDDGR PRPFQDTMSR FGSDSADAGV LLSPFLFDVL
310 320 330 340 350
HLDGRDLLDE PLAVRLDALA GLLADDAHAA LRMPGVRRPT AEQAAGVLDD
360 370 380 390 400
ALTAGHEGVV VKALDAPYAA GRRGKAWQKV KPVHTLDLVV LGAEWGYGRR
410 420 430 440 450
SGKLSNIHLG ARDPDGGEPV MVGKTFKGMT DELLDWQTAT FPDLAAEQPP
460 470 480 490 500
WGVLLRPELV VEIALDGAQR SPRYPGGVAL RFARVLRYRP DKTAAEADTI
510
DAVRALLAGG
Length:510
Mass (Da):53,622
Last modified:September 5, 2012 - v1
Checksum:i781BCECD7E5E82B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO203431 Genomic DNA Translation: CCH87715.1
RefSeqiWP_014740309.1, NC_017955.1

Genome annotation databases

EnsemblBacteriaiCCH87715; CCH87715; MODMU_2283
KEGGimmar:MODMU_2283
PATRICifig|477641.3.peg.2171

Similar proteinsi

Entry informationi

Entry nameiI4EWF2_9ACTN
AccessioniPrimary (citable) accession number: I4EWF2
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: March 28, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported