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I4EWF2

- I4EWF2_MODMB

UniProt

I4EWF2 - I4EWF2_MODMB

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Protein
Probable DNA ligase
Gene
ligB, lig, MODMU_2283
Organism
Modestobacter marinus (strain BC501)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei210 – 2101ATP By similarityUniRule annotation
Active sitei212 – 2121N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei217 – 2171ATP By similarityUniRule annotation
Binding sitei232 – 2321ATP By similarityUniRule annotation
Binding sitei261 – 2611ATP By similarityUniRule annotation
Binding sitei297 – 2971ATP By similarityUniRule annotation
Binding sitei373 – 3731ATP By similarityUniRule annotation
Binding sitei379 – 3791ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR477641:GLGK-2279-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligBImported
Synonyms:ligUniRule annotation
Ordered Locus Names:MODMU_2283Imported
OrganismiModestobacter marinus (strain BC501)
Taxonomic identifieri1144889 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeGeodermatophilaceaeModestobacter
ProteomesiUP000006461: Chromosome

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01971.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I4EWF2-1 [UniParc]FASTAAdd to Basket

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MLLADVLAVS AAVSATRSRT AKAQAIADLV RRAGDAEVEP VTAWLSGELR    50
QGRLGLGWRT LSRLTGEPAA EPSLTVGALD AALDELATTS GAGSAARRDA 100
LVGAVLAAAT ESEQQFLVRL LTGELRQGAL EGVVLDAVAL AADVPAAAVR 150
RAFMLSGRLP ETAATALTGG VAALDAVQLQ VGRPVRPMLA SPGSSLDAAL 200
TDLGSEVTVE FKLDGARIQV HRDGDVVRVW TRTLREVTDG VPELVDRIRA 250
LPCETAVLDG ETLALDDDGR PRPFQDTMSR FGSDSADAGV LLSPFLFDVL 300
HLDGRDLLDE PLAVRLDALA GLLADDAHAA LRMPGVRRPT AEQAAGVLDD 350
ALTAGHEGVV VKALDAPYAA GRRGKAWQKV KPVHTLDLVV LGAEWGYGRR 400
SGKLSNIHLG ARDPDGGEPV MVGKTFKGMT DELLDWQTAT FPDLAAEQPP 450
WGVLLRPELV VEIALDGAQR SPRYPGGVAL RFARVLRYRP DKTAAEADTI 500
DAVRALLAGG 510
Length:510
Mass (Da):53,622
Last modified:September 5, 2012 - v1
Checksum:i781BCECD7E5E82B3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO203431 Genomic DNA. Translation: CCH87715.1.
RefSeqiYP_006366202.1. NC_017955.1.

Genome annotation databases

EnsemblBacteriaiCCH87715; CCH87715; MODMU_2283.
GeneIDi13011040.
KEGGimmar:MODMU_2283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO203431 Genomic DNA. Translation: CCH87715.1 .
RefSeqi YP_006366202.1. NC_017955.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCH87715 ; CCH87715 ; MODMU_2283 .
GeneIDi 13011040.
KEGGi mmar:MODMU_2283.

Phylogenomic databases

KOi K01971.

Enzyme and pathway databases

BioCyci MMAR477641:GLGK-2279-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of radiation-resistant Modestobacter marinus strain BC501, a representative Actinobacterium that thrives on calcareous stone surfaces."
    Normand P., Gury J., Pujic P., Chouaia B., Crotti E., Brusetti L., Daffonchio D., Vacherie B., Barbe V., Medigue C., Calteau A., Ghodhbane-Gtari F., Essoussi I., Nouioui I., Abbassi-Ghozzi I., Gtari M.
    J. Bacteriol. 194:4773-4774(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BC501Imported.

Entry informationi

Entry nameiI4EWF2_MODMB
AccessioniPrimary (citable) accession number: I4EWF2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: June 11, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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