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Protein

Probable DNA ligase

Gene

ligB

Organism
Modestobacter marinus
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei210ATPUniRule annotation1
Active sitei212N6-AMP-lysine intermediateUniRule annotation1
Binding sitei217ATPUniRule annotation1
Binding sitei232ATPUniRule annotation1
Binding sitei261ATPUniRule annotation1
Binding sitei297ATPUniRule annotation1
Binding sitei373ATPUniRule annotation1
Binding sitei379ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligBImported
Synonyms:ligUniRule annotation
Ordered Locus Names:MODMU_2283Imported
OrganismiModestobacter marinusImported
Taxonomic identifieri477641 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaGeodermatophilalesGeodermatophilaceaeModestobacter
Proteomesi
  • UP000006461 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini295 – 413DNA_LIGASE_A3InterPro annotationAdd BLAST119

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OrthoDBiPOG091H0BGA.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I4EWF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLADVLAVS AAVSATRSRT AKAQAIADLV RRAGDAEVEP VTAWLSGELR
60 70 80 90 100
QGRLGLGWRT LSRLTGEPAA EPSLTVGALD AALDELATTS GAGSAARRDA
110 120 130 140 150
LVGAVLAAAT ESEQQFLVRL LTGELRQGAL EGVVLDAVAL AADVPAAAVR
160 170 180 190 200
RAFMLSGRLP ETAATALTGG VAALDAVQLQ VGRPVRPMLA SPGSSLDAAL
210 220 230 240 250
TDLGSEVTVE FKLDGARIQV HRDGDVVRVW TRTLREVTDG VPELVDRIRA
260 270 280 290 300
LPCETAVLDG ETLALDDDGR PRPFQDTMSR FGSDSADAGV LLSPFLFDVL
310 320 330 340 350
HLDGRDLLDE PLAVRLDALA GLLADDAHAA LRMPGVRRPT AEQAAGVLDD
360 370 380 390 400
ALTAGHEGVV VKALDAPYAA GRRGKAWQKV KPVHTLDLVV LGAEWGYGRR
410 420 430 440 450
SGKLSNIHLG ARDPDGGEPV MVGKTFKGMT DELLDWQTAT FPDLAAEQPP
460 470 480 490 500
WGVLLRPELV VEIALDGAQR SPRYPGGVAL RFARVLRYRP DKTAAEADTI
510
DAVRALLAGG
Length:510
Mass (Da):53,622
Last modified:September 5, 2012 - v1
Checksum:i781BCECD7E5E82B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO203431 Genomic DNA. Translation: CCH87715.1.
RefSeqiWP_014740309.1. NC_017955.1.

Genome annotation databases

EnsemblBacteriaiCCH87715; CCH87715; MODMU_2283.
KEGGimmar:MODMU_2283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO203431 Genomic DNA. Translation: CCH87715.1.
RefSeqiWP_014740309.1. NC_017955.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCH87715; CCH87715; MODMU_2283.
KEGGimmar:MODMU_2283.

Phylogenomic databases

KOiK10747.
OrthoDBiPOG091H0BGA.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI4EWF2_9ACTN
AccessioniPrimary (citable) accession number: I4EWF2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: November 2, 2016
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.