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I4EWF2

- I4EWF2_MODMB

UniProt

I4EWF2 - I4EWF2_MODMB

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Protein

Probable DNA ligase

Gene

ligB

Organism
Modestobacter marinus (strain BC501)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Note: Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei210 – 2101ATPUniRule annotation
Active sitei212 – 2121N6-AMP-lysine intermediateUniRule annotation
Binding sitei217 – 2171ATPUniRule annotation
Binding sitei232 – 2321ATPUniRule annotation
Binding sitei261 – 2611ATPUniRule annotation
Binding sitei297 – 2971ATPUniRule annotation
Binding sitei373 – 3731ATPUniRule annotation
Binding sitei379 – 3791ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR477641:GLGK-2279-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligBImported
Synonyms:ligUniRule annotation
Ordered Locus Names:MODMU_2283Imported
OrganismiModestobacter marinus (strain BC501)Imported
Taxonomic identifieri1144889 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeGeodermatophilaceaeModestobacter
ProteomesiUP000006461: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK01971.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I4EWF2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLADVLAVS AAVSATRSRT AKAQAIADLV RRAGDAEVEP VTAWLSGELR
60 70 80 90 100
QGRLGLGWRT LSRLTGEPAA EPSLTVGALD AALDELATTS GAGSAARRDA
110 120 130 140 150
LVGAVLAAAT ESEQQFLVRL LTGELRQGAL EGVVLDAVAL AADVPAAAVR
160 170 180 190 200
RAFMLSGRLP ETAATALTGG VAALDAVQLQ VGRPVRPMLA SPGSSLDAAL
210 220 230 240 250
TDLGSEVTVE FKLDGARIQV HRDGDVVRVW TRTLREVTDG VPELVDRIRA
260 270 280 290 300
LPCETAVLDG ETLALDDDGR PRPFQDTMSR FGSDSADAGV LLSPFLFDVL
310 320 330 340 350
HLDGRDLLDE PLAVRLDALA GLLADDAHAA LRMPGVRRPT AEQAAGVLDD
360 370 380 390 400
ALTAGHEGVV VKALDAPYAA GRRGKAWQKV KPVHTLDLVV LGAEWGYGRR
410 420 430 440 450
SGKLSNIHLG ARDPDGGEPV MVGKTFKGMT DELLDWQTAT FPDLAAEQPP
460 470 480 490 500
WGVLLRPELV VEIALDGAQR SPRYPGGVAL RFARVLRYRP DKTAAEADTI
510
DAVRALLAGG
Length:510
Mass (Da):53,622
Last modified:September 5, 2012 - v1
Checksum:i781BCECD7E5E82B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO203431 Genomic DNA. Translation: CCH87715.1.
RefSeqiYP_006366202.1. NC_017955.1.

Genome annotation databases

EnsemblBacteriaiCCH87715; CCH87715; MODMU_2283.
GeneIDi13011040.
KEGGimmar:MODMU_2283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO203431 Genomic DNA. Translation: CCH87715.1 .
RefSeqi YP_006366202.1. NC_017955.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCH87715 ; CCH87715 ; MODMU_2283 .
GeneIDi 13011040.
KEGGi mmar:MODMU_2283.

Phylogenomic databases

KOi K01971.

Enzyme and pathway databases

BioCyci MMAR477641:GLGK-2279-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of radiation-resistant Modestobacter marinus strain BC501, a representative Actinobacterium that thrives on calcareous stone surfaces."
    Normand P., Gury J., Pujic P., Chouaia B., Crotti E., Brusetti L., Daffonchio D., Vacherie B., Barbe V., Medigue C., Calteau A., Ghodhbane-Gtari F., Essoussi I., Nouioui I., Abbassi-Ghozzi I., Gtari M.
    J. Bacteriol. 194:4773-4774(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BC501Imported.

Entry informationi

Entry nameiI4EWF2_MODMB
AccessioniPrimary (citable) accession number: I4EWF2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: November 26, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3