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I4E1A6

- I4E1A6_STRIJ

UniProt

I4E1A6 - I4E1A6_STRIJ

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Protein
Alanine racemase
Gene
alr, SCIM_1292
Organism
Streptococcus intermedius (strain JTH08)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei136 – 1361Substrate By similarityUniRule annotation
Active sitei263 – 2631Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei310 – 3101Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciSINT591365:GLL4-1344-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:SCIM_1292Imported
OrganismiStreptococcus intermedius (strain JTH08)Imported
Taxonomic identifieri591365 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcusStreptococcus anginosus group
ProteomesiUP000002897: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI4E1A6.

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiIYSHLAL.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I4E1A6-1 [UniParc]FASTAAdd to Basket

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MKTSNHRPTK AIVDLAAIHF NIKQIAAHIP GDVEKWAVVK ADAYGHGAVA    50
VTQSIEPIVD GFCVSNIDEA LELREAGISK KILVLGVSTI QSVPLAMKYK 100
ITYTVASLEW IDLLLQSNID VTGLVVHIKI DSGMGRIGFR NSQDAQEAIH 150
RLKKVGAQVE GIFTHFATAD EADTQKFAAQ LARFKEILER LDIVPPIVHA 200
SNSATTLWHA DTVMKAVRLG DIIYGLNPSG RTLELPYEMK PALSLISELV 250
HVKQLEAGAD IGYGATYTSD SPQFIGTIPL GYADGWTRDM QGFNVLIDGK 300
ACPVVGRVSM DQITVRLPRF YPIGTSVVFI GKSGEEVISA TDVAEKRGTI 350
NYEVVCLLSD RVPRIYKK 368
Length:368
Mass (Da):40,166
Last modified:September 5, 2012 - v1
Checksum:iEE810F97C47D724B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP010969 Genomic DNA. Translation: BAM23946.1.
RefSeqiYP_006470194.1. NC_018073.1.

Genome annotation databases

EnsemblBacteriaiBAM23946; BAM23946; SCIM_1292.
GeneIDi13155743.
KEGGisie:SCIM_1292.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP010969 Genomic DNA. Translation: BAM23946.1 .
RefSeqi YP_006470194.1. NC_018073.1.

3D structure databases

ProteinModelPortali I4E1A6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAM23946 ; BAM23946 ; SCIM_1292 .
GeneIDi 13155743.
KEGGi sie:SCIM_1292.

Phylogenomic databases

KOi K01775.
OMAi IYSHLAL.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci SINT591365:GLL4-1344-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequencing of Streptococcus intermedius, a pathogen of human purulent infections."
    Kikuchi K., Baba T., Sasaki T., Kishii K., Takeuchi F., Watanabe S., Sekine M., Matsuo M., Cui L., Ito T., Hiramatsu K.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JTH08Imported.

Entry informationi

Entry nameiI4E1A6_STRIJ
AccessioniPrimary (citable) accession number: I4E1A6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: July 9, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi