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I4E1A6

- I4E1A6_STRIJ

UniProt

I4E1A6 - I4E1A6_STRIJ

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Protein

Alanine racemase

Gene

alr

Organism
Streptococcus intermedius (strain JTH08)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei136 – 1361SubstrateUniRule annotation
Active sitei263 – 2631Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei310 – 3101Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSINT591365:GLL4-1344-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:SCIM_1292Imported
OrganismiStreptococcus intermedius (strain JTH08)Imported
Taxonomic identifieri591365 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcusStreptococcus anginosus group
ProteomesiUP000002897: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI4E1A6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiIYSHLAL.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I4E1A6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTSNHRPTK AIVDLAAIHF NIKQIAAHIP GDVEKWAVVK ADAYGHGAVA
60 70 80 90 100
VTQSIEPIVD GFCVSNIDEA LELREAGISK KILVLGVSTI QSVPLAMKYK
110 120 130 140 150
ITYTVASLEW IDLLLQSNID VTGLVVHIKI DSGMGRIGFR NSQDAQEAIH
160 170 180 190 200
RLKKVGAQVE GIFTHFATAD EADTQKFAAQ LARFKEILER LDIVPPIVHA
210 220 230 240 250
SNSATTLWHA DTVMKAVRLG DIIYGLNPSG RTLELPYEMK PALSLISELV
260 270 280 290 300
HVKQLEAGAD IGYGATYTSD SPQFIGTIPL GYADGWTRDM QGFNVLIDGK
310 320 330 340 350
ACPVVGRVSM DQITVRLPRF YPIGTSVVFI GKSGEEVISA TDVAEKRGTI
360
NYEVVCLLSD RVPRIYKK
Length:368
Mass (Da):40,166
Last modified:September 5, 2012 - v1
Checksum:iEE810F97C47D724B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010969 Genomic DNA. Translation: BAM23946.1.
RefSeqiYP_006470194.1. NC_018073.1.

Genome annotation databases

EnsemblBacteriaiBAM23946; BAM23946; SCIM_1292.
GeneIDi13155743.
KEGGisie:SCIM_1292.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010969 Genomic DNA. Translation: BAM23946.1 .
RefSeqi YP_006470194.1. NC_018073.1.

3D structure databases

ProteinModelPortali I4E1A6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAM23946 ; BAM23946 ; SCIM_1292 .
GeneIDi 13155743.
KEGGi sie:SCIM_1292.

Phylogenomic databases

KOi K01775.
OMAi IYSHLAL.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci SINT591365:GLL4-1344-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequencing of Streptococcus intermedius, a pathogen of human purulent infections."
    Kikuchi K., Baba T., Sasaki T., Kishii K., Takeuchi F., Watanabe S., Sekine M., Matsuo M., Cui L., Ito T., Hiramatsu K.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JTH08Imported.

Entry informationi

Entry nameiI4E1A6_STRIJ
AccessioniPrimary (citable) accession number: I4E1A6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: November 26, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3