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I4D3Z6

- I4D3Z6_DESAJ

UniProt

I4D3Z6 - I4D3Z6_DESAJ

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Protein

Thymidine kinase

Gene

tdk

Organism
Desulfosporosinus acidiphilus (strain DSM 22704 / JCM 16185 / SJ4)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841Proton acceptorUniRule annotation
Metal bindingi141 – 1411ZincUniRule annotation
Metal bindingi144 – 1441ZincUniRule annotation
Metal bindingi178 – 1781ZincUniRule annotation
Metal bindingi181 – 1811ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi83 – 864ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciDACI646529:GLCJ-1505-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Desaci_1507Imported
OrganismiDesulfosporosinus acidiphilus (strain DSM 22704 / JCM 16185 / SJ4)Imported
Taxonomic identifieri646529 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfosporosinus
ProteomesiUP000002892: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.
OMAiAIPITAD.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I4D3Z6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQLYFRYAT MGSGKTADLL KIAYNYTEQE KKVLIFTPAI DTRFGVGRVT
60 70 80 90 100
SRMGISKPAI TIDPKTDIFD LVQREMPDCV LCDEGNFLTR GNVLEFCRVV
110 120 130 140 150
DELDIPVIIY GLKNDFQNNL FEGSEALLIY ADKIEEVKTV CWYCNRKATM
160 170 180 190
VLRFKDGVPI FEGQQIEVGG NESYLPVCRR CWNKAREGTK AKSD
Length:194
Mass (Da):22,078
Last modified:September 5, 2012 - v1
Checksum:i9DCC2BBC6AB514D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003639 Genomic DNA. Translation: AFM40520.1.
RefSeqiYP_006465852.1. NC_018068.1.

Genome annotation databases

EnsemblBacteriaiAFM40520; AFM40520; Desaci_1507.
GeneIDi13152679.
KEGGidai:Desaci_1507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003639 Genomic DNA. Translation: AFM40520.1 .
RefSeqi YP_006465852.1. NC_018068.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFM40520 ; AFM40520 ; Desaci_1507 .
GeneIDi 13152679.
KEGGi dai:Desaci_1507.

Phylogenomic databases

KOi K00857.
OMAi AIPITAD.

Enzyme and pathway databases

BioCyci DACI646529:GLCJ-1505-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 22704 / JCM 16185 / SJ4Imported.

Entry informationi

Entry nameiI4D3Z6_DESAJ
AccessioniPrimary (citable) accession number: I4D3Z6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: November 26, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3