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I4D3Z6

- I4D3Z6_DESAJ

UniProt

I4D3Z6 - I4D3Z6_DESAJ

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Protein
Thymidine kinase
Gene
tdk, Desaci_1507
Organism
Desulfosporosinus acidiphilus (strain DSM 22704 / JCM 16185 / SJ4)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841Proton acceptor By similarityUniRule annotation
Metal bindingi141 – 1411Zinc By similarityUniRule annotation
Metal bindingi144 – 1441Zinc By similarityUniRule annotation
Metal bindingi178 – 1781Zinc By similarityUniRule annotation
Metal bindingi181 – 1811Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarityUniRule annotation
Nucleotide bindingi83 – 864ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciDACI646529:GLCJ-1505-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Desaci_1507Imported
OrganismiDesulfosporosinus acidiphilus (strain DSM 22704 / JCM 16185 / SJ4)Imported
Taxonomic identifieri646529 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfosporosinus
ProteomesiUP000002892: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.
OMAiAIPITAD.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I4D3Z6-1 [UniParc]FASTAAdd to Basket

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MAQLYFRYAT MGSGKTADLL KIAYNYTEQE KKVLIFTPAI DTRFGVGRVT    50
SRMGISKPAI TIDPKTDIFD LVQREMPDCV LCDEGNFLTR GNVLEFCRVV 100
DELDIPVIIY GLKNDFQNNL FEGSEALLIY ADKIEEVKTV CWYCNRKATM 150
VLRFKDGVPI FEGQQIEVGG NESYLPVCRR CWNKAREGTK AKSD 194
Length:194
Mass (Da):22,078
Last modified:September 5, 2012 - v1
Checksum:i9DCC2BBC6AB514D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003639 Genomic DNA. Translation: AFM40520.1.
RefSeqiYP_006465852.1. NC_018068.1.

Genome annotation databases

EnsemblBacteriaiAFM40520; AFM40520; Desaci_1507.
GeneIDi13152679.
KEGGidai:Desaci_1507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003639 Genomic DNA. Translation: AFM40520.1 .
RefSeqi YP_006465852.1. NC_018068.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFM40520 ; AFM40520 ; Desaci_1507 .
GeneIDi 13152679.
KEGGi dai:Desaci_1507.

Phylogenomic databases

KOi K00857.
OMAi AIPITAD.

Enzyme and pathway databases

BioCyci DACI646529:GLCJ-1505-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 22704 / JCM 16185 / SJ4.

Entry informationi

Entry nameiI4D3Z6_DESAJ
AccessioniPrimary (citable) accession number: I4D3Z6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: June 11, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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