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I4C3Q6 (I4C3Q6_DESTA) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Desti_1485 EMBL AFM24197.1
OrganismDesulfomonile tiedjei (strain ATCC 49306 / DSM 6799 / DCB-1) [Complete proteome] [HAMAP] EMBL AFM24197.1
Taxonomic identifier706587 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaSyntrophobacteralesSyntrophaceaeDesulfomonile

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain144 – 348205ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding176 – 23156ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3021Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3151Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3151Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3171Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
I4C3Q6 [UniParc].

Last modified September 5, 2012. Version 1.
Checksum: 160F657B5D8B912E

FASTA36740,370
        10         20         30         40         50         60 
MQNPRLRIAL VYGGQSAEHE VSLRSARSIF DAMDRSKYDP LPILITQQGS WYSMPAEAAS 

        70         80         90        100        110        120 
FDPSVSPARS NRLIFSPDPQ HRGFLKVDGE SGIQPMHVDL VFPVLHGTYG EDGTIQGLLE 

       130        140        150        160        170        180 
MAHMPYVGCG VLASAVGMDK ILMKKAFREN GLNIGPYFWF FRAEWESDPD KITAKLKSAH 

       190        200        210        220        230        240 
FPLFVKPANL GSSVGISKVS DPSGFEAAVN LAASYDRKIL VEDGIEGREL EVSVLGNDHP 

       250        260        270        280        290        300 
KASVAGEVIS HSSFYDYEEK YLKDTAELVI PAELPAGMLQ KAQEAAITAF RAVDGSGLGR 

       310        320        330        340        350        360 
VDMFLTPDNQ VVVNEINTLP GFTSISMYPK LWEATGLPYA QLVDRLVGLA QERHREKLTI 


RTDRKPV 

« Hide

References

[1]"Complete sequence of chromosome of Desulfomonile tiedjei DSM 6799."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Peters L., Ovchinnikova G., Zeytun A., Lu M., Kyrpides N., Mavromatis K., Ivanova N., Brettin T., Detter J.C. expand/collapse author list , Han C., Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Spring S., Schroeder M., Brambilla E., Klenk H.-P., Eisen J.A.
Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49306 / DSM 6799 / DCB-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003360 Genomic DNA. Translation: AFM24197.1.
RefSeqYP_006446461.1. NC_018025.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFM24197; AFM24197; Desti_1485.
GeneID13138530.
KEGGdti:Desti_1485.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMAHNGLLKN.

Enzyme and pathway databases

BioCycDTIE706587:GLCI-1483-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI4C3Q6_DESTA
AccessionPrimary (citable) accession number: I4C3Q6
Entry history
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: June 11, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)