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I4BH91 (I4BH91_MYCCN) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Mycch_1861 EMBL AFM16648.1
OrganismMycobacterium chubuense (strain NBB4) [Complete proteome] [HAMAP] EMBL AFM16648.1
Taxonomic identifier710421 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain150 – 357208ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding178 – 23356ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3121Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3241Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3241Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3261Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
I4BH91 [UniParc].

Last modified September 5, 2012. Version 1.
Checksum: 35F6A4A6E6457F1C

FASTA36738,961
        10         20         30         40         50         60 
MTARIRVAVV YGGRSSEHAI SCVSAGSILR NLDPERFEVV AVGITPEGSW VLTDGRPETL 

        70         80         90        100        110        120 
AITDGRLPGV DASSGTELAL AADPGRRGQL VALGDGAAEV LTSVDVVFPV LHGPYGEDGT 

       130        140        150        160        170        180 
IQGLLELAGV PYVGAGVLAS AAGMDKEFTK KLLAAEELPI GDQVVLHPRE ATLSFEDRER 

       190        200        210        220        230        240 
LGLPVFVKPA RGGSSIGVSR VTSWDMLAPA IELARRHDPK VIVEAAVPGR ELECGVLEFP 

       250        260        270        280        290        300 
DGRVEASTVG EIRVAGVRGR EDGFYDFETK YLDDGAELDV PAKVDDSIAE QIRGLSIRAF 

       310        320        330        340        350        360 
RAIDCQGLAR VDFFLTDAGP VINEINTMPG FTTISMYPRM WAASGMDYPT LLATMVETAL 


ARGTGLR 

« Hide

References

[1]"Complete sequence of chromosome of Mycobacterium chubuense NBB4."
US DOE Joint Genome Institute
Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Mattes T. expand/collapse author list , Holmes A., Rutledge P., Paulsen I., Coleman N., Woyke T.
Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NBB4 EMBL AFM16648.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003053 Genomic DNA. Translation: AFM16648.1.
RefSeqYP_006452327.1. NC_018027.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFM16648; AFM16648; Mycch_1861.
GeneID13144671.
KEGGmcb:Mycch_1861.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycMCHU710421:GLGL-1860-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI4BH91_MYCCN
AccessionPrimary (citable) accession number: I4BH91
Entry history
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: February 19, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)