UniProtKB - I4BGZ8 (I4BGZ8_MYCCN)
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Protein
Probable DNA ligase
Gene
lig
Organism
Mycobacterium chubuense (strain NBB4)
Status
Functioni
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation
Catalytic activityi
ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation
Cofactori
Mg2+UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 213 | ATPUniRule annotation | 1 | |
Active sitei | 215 | N6-AMP-lysine intermediateUniRule annotation | 1 | |
Binding sitei | 220 | ATPUniRule annotation | 1 | |
Binding sitei | 235 | ATPUniRule annotation | 1 | |
Binding sitei | 264 | ATPUniRule annotation | 1 | |
Binding sitei | 303 | ATPUniRule annotation | 1 | |
Binding sitei | 375 | ATPUniRule annotation | 1 | |
Binding sitei | 381 | ATPUniRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- DNA binding Source: InterPro
- DNA ligase (ATP) activity Source: UniProtKB-UniRule
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- DNA biosynthetic process Source: InterPro
- DNA ligation involved in DNA repair Source: InterPro
- DNA recombination Source: UniProtKB-UniRule
- DNA replication Source: UniProtKB-UniRule
Keywordsi
Molecular function | LigaseUniRule annotationImported |
Biological process | Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation |
Ligand | ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)Alternative name(s): Polydeoxyribonucleotide synthase [ATP]UniRule annotation |
Gene namesi | Name:ligUniRule annotation Ordered Locus Names:Mycch_1764Imported |
Organismi | Mycobacterium chubuense (strain NBB4)Imported |
Taxonomic identifieri | 710421 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › |
Proteomesi |
|
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 291 – 415 | DNA_LIGASE_A3InterPro annotationAdd BLAST | 125 |
Sequence similaritiesi
Belongs to the ATP-dependent DNA ligase family.UniRule annotation
Phylogenomic databases
KOi | K10747. |
OMAi | WLFEESY. |
OrthoDBi | POG091H0BGA. |
Family and domain databases
Gene3Di | 1.10.3260.10. 1 hit. |
HAMAPi | MF_00407. DNA_ligase. 1 hit. |
InterProi | View protein in InterPro IPR022865. DNA_ligae_ATP-dep_bac/arc. IPR000977. DNA_ligase_ATP-dep. IPR012309. DNA_ligase_ATP-dep_C. IPR012310. DNA_ligase_ATP-dep_cent. IPR016059. DNA_ligase_ATP-dep_CS. IPR012308. DNA_ligase_ATP-dep_N. IPR036599. DNA_ligase_N_sf. IPR012340. NA-bd_OB-fold. |
Pfami | View protein in Pfam PF04679. DNA_ligase_A_C. 1 hit. PF01068. DNA_ligase_A_M. 1 hit. PF04675. DNA_ligase_A_N. 1 hit. |
SUPFAMi | SSF117018. SSF117018. 1 hit. SSF50249. SSF50249. 1 hit. |
TIGRFAMsi | TIGR00574. dnl1. 1 hit. |
PROSITEi | View protein in PROSITE PS00697. DNA_LIGASE_A1. 1 hit. PS00333. DNA_LIGASE_A2. 1 hit. PS50160. DNA_LIGASE_A3. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
I4BGZ8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLVEVAQAS ADVAAASARL AKIARIADLL RSAAAAGDPR LVAVVVSWLS
60 70 80 90 100
GELTQRQIGV GWASLRALPE PAAEPTLTVL GVDGALGDIG TTSGKGSQAR
110 120 130 140 150
RARLVAELFS AATAIEQTFL RRLLTGELRQ GALVGVMADA VSKAAGIDPA
160 170 180 190 200
AARRAAMLSG DLPTVAAAAV TGGVAALEAF TLQVGRPVGP MLAQTATSVA
210 220 230 240 250
DALERLDGRA VFEAKLDGAR VQIHRRGDSV SVFTRSLDDV TARLPEVVDA
260 270 280 290 300
ALALPVTDLI ADAEAIALRP DGRPQRFQVT ASRFGRRGGT AGPDTQKLSV
310 320 330 340 350
FFFDLLHVDG VDVLDQPAHE RVARLDAIVP DRQRVDRLLT TDPAEAQTFL
360 370 380 390 400
DTTLAAGHEG VMAKSPTAPY EAGRRGAGWL KVKPVHTLDL VVLAVEWGSG
410 420 430 440 450
RRTGKLSNIH LGARDPQTGG FVMLGKTFKG MTDEMLAWQT ERFLELADGL
460 470 480 490 500
TSGYSVRVRP EQVVEIAFDG LQTSSRYPGG MALRFARVLR YRDDKSAAEA
510
DTIDTVRALY ERSD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP003053 Genomic DNA. Translation: AFM16555.1. |
RefSeqi | WP_014815036.1. NC_018027.1. |
Genome annotation databases
EnsemblBacteriai | AFM16555; AFM16555; Mycch_1764. |
KEGGi | mcb:Mycch_1764. |
PATRICi | fig|710421.3.peg.1767. |
Similar proteinsi
Entry informationi
Entry namei | I4BGZ8_MYCCN | |
Accessioni | I4BGZ8Primary (citable) accession number: I4BGZ8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 5, 2012 |
Last sequence update: | September 5, 2012 | |
Last modified: | March 28, 2018 | |
This is version 39 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |