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I4BGZ8 (I4BGZ8_MYCCN) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Probable DNA ligase HAMAP-Rule MF_00407
EC=6.5.1.1 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig HAMAP-Rule MF_00407
Ordered Locus Names:Mycch_1764 EMBL AFM16555.1
OrganismMycobacterium chubuense (strain NBB4) [Complete proteome] [HAMAP] EMBL AFM16555.1
Taxonomic identifier710421 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium ›

Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617 HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential EMBL AFM16555.1
Chain28 – 514487 Potential EMBL AFM16555.1
PRO_5000912910

Sites

Active site2151N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2131ATP By similarity HAMAP-Rule MF_00407
Binding site2201ATP By similarity HAMAP-Rule MF_00407
Binding site2351ATP By similarity HAMAP-Rule MF_00407
Binding site2641ATP By similarity HAMAP-Rule MF_00407
Binding site3031ATP By similarity HAMAP-Rule MF_00407
Binding site3751ATP By similarity HAMAP-Rule MF_00407
Binding site3811ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
I4BGZ8 [UniParc].

Last modified September 5, 2012. Version 1.
Checksum: 593838EFAEA08301

FASTA51454,463
        10         20         30         40         50         60 
MLLVEVAQAS ADVAAASARL AKIARIADLL RSAAAAGDPR LVAVVVSWLS GELTQRQIGV 

        70         80         90        100        110        120 
GWASLRALPE PAAEPTLTVL GVDGALGDIG TTSGKGSQAR RARLVAELFS AATAIEQTFL 

       130        140        150        160        170        180 
RRLLTGELRQ GALVGVMADA VSKAAGIDPA AARRAAMLSG DLPTVAAAAV TGGVAALEAF 

       190        200        210        220        230        240 
TLQVGRPVGP MLAQTATSVA DALERLDGRA VFEAKLDGAR VQIHRRGDSV SVFTRSLDDV 

       250        260        270        280        290        300 
TARLPEVVDA ALALPVTDLI ADAEAIALRP DGRPQRFQVT ASRFGRRGGT AGPDTQKLSV 

       310        320        330        340        350        360 
FFFDLLHVDG VDVLDQPAHE RVARLDAIVP DRQRVDRLLT TDPAEAQTFL DTTLAAGHEG 

       370        380        390        400        410        420 
VMAKSPTAPY EAGRRGAGWL KVKPVHTLDL VVLAVEWGSG RRTGKLSNIH LGARDPQTGG 

       430        440        450        460        470        480 
FVMLGKTFKG MTDEMLAWQT ERFLELADGL TSGYSVRVRP EQVVEIAFDG LQTSSRYPGG 

       490        500        510 
MALRFARVLR YRDDKSAAEA DTIDTVRALY ERSD

« Hide

References

[1]"Complete sequence of chromosome of Mycobacterium chubuense NBB4."
US DOE Joint Genome Institute
Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Mattes T. expand/collapse author list , Holmes A., Rutledge P., Paulsen I., Coleman N., Woyke T.
Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NBB4 EMBL AFM16555.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003053 Genomic DNA. Translation: AFM16555.1.
RefSeqYP_006452234.1. NC_018027.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFM16555; AFM16555; Mycch_1764.
GeneID13144574.
KEGGmcb:Mycch_1764.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01971.

Enzyme and pathway databases

BioCycMCHU710421:GLGL-1763-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI4BGZ8_MYCCN
AccessionPrimary (citable) accession number: I4BGZ8
Entry history
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: February 19, 2014
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info