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Protein

Glutamate decarboxylase

Gene

Mycch_1085

Organism
Mycobacterium chubuense (strain NBB4)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciMCHU710421:GLGL-1085-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:Mycch_1085Imported
OrganismiMycobacterium chubuense (strain NBB4)Imported
Taxonomic identifieri710421 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000006057: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 PotentialImportedAdd
BLAST
Chaini26 – 467442 PotentialImportedPRO_5000912752Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

KOiK01580.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

I4BF37-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPNVSRHTSL TPAYTGRMFT SPIPALRLPD ESMDPEQAYR FIHDELMLDG
60 70 80 90 100
SSRLNLATFV TTWMDPEAGQ LMSETFDKNM IDKDEYPVTA AIEQRCVCMV
110 120 130 140 150
ADLFHAEHLR DDDPSTAIGV STIGSSEAVM LAGLALKWRW RQKLEAAGQD
160 170 180 190 200
WKGRTPNLVM GSNVQVVWEK FCRYFDVEAR YLPMDKGRYV ITPEQVVDAV
210 220 230 240 250
DEDTIGVVAI LGTTFTGELE PVGEICAALD TLARGDGPDV PVHVDAASGG
260 270 280 290 300
FVVPFLHPDM VWDFRLPRVV SINVSGHKYG LTYPGIGFVV WRNADHLPEE
310 320 330 340 350
LVFRVNYLGG DMPTFTLNFS RPGNQVVGQY YNFLRLGRDG YMSVMHCLSD
360 370 380 390 400
TAQWLARELA GMSGPDNTPV FDVISDGSAI PVVAFKLVEG TKFTVFDVSA
410 420 430 440 450
LLRSYGWQVP AYTMPDHASD IAVLRIVVRE GFSANLARAL RDDLVEVLGK
460
LERTGVAGFS DEEHFAH
Length:467
Mass (Da):51,782
Last modified:September 5, 2012 - v1
Checksum:iF38F4DFE3138ADDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003053 Genomic DNA. Translation: AFM15894.1.
RefSeqiYP_006451573.1. NC_018027.1.

Genome annotation databases

EnsemblBacteriaiAFM15894; AFM15894; Mycch_1085.
GeneIDi13141276.
KEGGimcb:Mycch_1085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003053 Genomic DNA. Translation: AFM15894.1.
RefSeqiYP_006451573.1. NC_018027.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFM15894; AFM15894; Mycch_1085.
GeneIDi13141276.
KEGGimcb:Mycch_1085.

Phylogenomic databases

KOiK01580.

Enzyme and pathway databases

BioCyciMCHU710421:GLGL-1085-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Mycobacterium chubuense NBB4."
    US DOE Joint Genome Institute
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Mattes T.
    , Holmes A., Rutledge P., Paulsen I., Coleman N., Woyke T.
    Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NBB4Imported.

Entry informationi

Entry nameiI4BF37_MYCCN
AccessioniPrimary (citable) accession number: I4BF37
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: February 4, 2015
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.