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I4B3K5

- I4B3K5_TURPD

UniProt

I4B3K5 - I4B3K5_TURPD

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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

Turpa_1214

Organism
Turneriella parva (strain ATCC BAA-1111 / DSM 21527 / NCTC 11395 / H) (Leptospira parva)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
Sitei422 – 4221Critical for catalysis
Binding sitei549 – 5491SubstrateUniRule annotation
Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation
Metal bindingi554 – 5541Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciTPAR869212:GLMM-1192-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported
Gene namesi
Ordered Locus Names:Turpa_1214Imported
OrganismiTurneriella parva (strain ATCC BAA-1111 / DSM 21527 / NCTC 11395 / H) (Leptospira parva)Imported
Taxonomic identifieri869212 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeTurneriella
ProteomesiUP000006048: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434 PotentialImportedAdd
BLAST
Chaini35 – 742708 PotentialImportedPRO_5000911343Add
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

I4B3K5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADSKSKIIW TKIDEAPALA TYSLLPIVNA FTKAAGVVVE TCDISLAGRI
60 70 80 90 100
LANFPENLSE SQKVADGLAA LGKLVLLPEA NVIKLPNISA SIPQLKAAIK
110 120 130 140 150
ELQSQGYKVP DYPEEPKTED EKAIKARYAK VLGSAVNPVL REGNSDRRVA
160 170 180 190 200
RSVKEFAKKN PHKLGEWSKE CKSHVANMKA GDFFHNEKSV TIEDATDVKF
210 220 230 240 250
EFEDKSGNKT VLKEKLSLKK GEVFDATFMS AKALRQFIED QLADAKAKNL
260 270 280 290 300
LFSVHLKATM MKVSDPIIFG HFVSVYFKDV FAKHAATFQK LGVNPDLGLG
310 320 330 340 350
DLYAKIKTLP DAERAEIEAD IQATYSVRPP LAMVDSAKGI TNLHAGNDVI
360 370 380 390 400
IDASMPVVIR DSGKMWGPDG KLHECKAVIP DTSYAEFYQT GFDFCRQQGA
410 420 430 440 450
FDPRVMGNVA NVGLMAQQAE EYGSHDKTFK APGDGVIRVI DAAGKVLTEH
460 470 480 490 500
HVETGDIWRA CQTKDEAIRD WVKLAVRRAR ATGSPAVFWL TSARAHDAQI
510 520 530 540 550
IAKVNTYLKE HDTSGLEIHI LSLVDAMQFT LERVKAGKDT ISVTGNVMRD
560 570 580 590 600
YLTDLFPILE LNTSAKMLSI VPLLNGGGLF ETGAGGSAPK HVQQFQQEGY
610 620 630 640 650
LRWDSTGEFL ALGVSLEHLA ATFKNAKAQV LADTIDKAFG KFLDNNKSPA
660 670 680 690 700
RKVGEIDNRG SHFYFGLYWA QALAEQTADK ELQARFAPIA KQLTENEAKI
710 720 730 740
DKELIDAQGK PVDMGGYFHP DDAKTAKAMR PSATLNSIID AI
Length:742
Mass (Da):81,285
Last modified:September 5, 2012 - v1
Checksum:i1220201EC922CCAB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002959 Genomic DNA. Translation: AFM11862.1.
RefSeqiYP_006439368.1. NC_018020.1.

Genome annotation databases

EnsemblBacteriaiAFM11862; AFM11862; Turpa_1214.
GeneIDi13128119.
KEGGitpx:Turpa_1214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002959 Genomic DNA. Translation: AFM11862.1 .
RefSeqi YP_006439368.1. NC_018020.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFM11862 ; AFM11862 ; Turpa_1214 .
GeneIDi 13128119.
KEGGi tpx:Turpa_1214.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci TPAR869212:GLMM-1192-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1111 / DSM 21527 / NCTC 11395 / HImported.

Entry informationi

Entry nameiI4B3K5_TURPD
AccessioniPrimary (citable) accession number: I4B3K5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: October 29, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3