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Protein

Alanine racemase

Gene

Fleli_0871

Organism
Bernardetia litoralis (strain ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4) (Flexibacter litoralis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Fleli_1522), Alanine racemase (Fleli_0871)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei36Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei135SubstrateUniRule annotation1
Active sitei278Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei326Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciFLIT880071:G1H5S-986-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Fleli_0871Imported
OrganismiBernardetia litoralis (strain ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4) (Flexibacter litoralis)Imported
Taxonomic identifieri880071 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesBernardetiaceaeBernardetia
Proteomesi
  • UP000006054 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliI4AH93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini257 – 385Ala_racemase_CInterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01775
OMAiWEILCGF
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

I4AH93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSTSHIEIS KSALQNNYHF LRQLIGENVT LSSVVKGNAY GHGLENFIPL
60 70 80 90 100
AESCGASHFS VFSADEAFEV QKLKKENSQI MILGMIGNEE LEWAIRTSIE
110 120 130 140 150
VYMFDLERLE VGLQIAQKMQ MPIKIHLEME TGMNRIGIAK KDIPKVFQLL
160 170 180 190 200
TNYPNCYILE GISTHYAGAE SIANYVRVKQ QIINYKKIVK RFQRKENPAF
210 220 230 240 250
IPKKYHTACS AATIAYPQTR MDMVRIGILQ YGFFPTQETL IQYLKDNKTH
260 270 280 290 300
IDPLKRVLSW KSKIMTIKDV EAGEFIGYGT SFLASQKMKI AIVPVGYAHG
310 320 330 340 350
YSRSLSNMGR VLVRGERMAV VGVVNMNLMI IDLEKMQSAE IGDEVILIGK
360 370 380
QGEQEVSVAS FSEMSNQLNY ELLTRLPMNI PRKIVE
Length:386
Mass (Da):43,751
Last modified:September 5, 2012 - v1
Checksum:iB9C5A05C1D6A57B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003345 Genomic DNA Translation: AFM03328.1
RefSeqiWP_014796786.1, NC_018018.1

Genome annotation databases

EnsemblBacteriaiAFM03328; AFM03328; Fleli_0871
KEGGifli:Fleli_0871
PATRICifig|880071.3.peg.847

Similar proteinsi

Entry informationi

Entry nameiI4AH93_BERLS
AccessioniPrimary (citable) accession number: I4AH93
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: February 28, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health