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I4AFR2 (I4AFR2_FLELS) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 7. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] RuleBase RU004446
EC=1.1.1.42 RuleBase RU004446
Gene names
Ordered Locus Names:Fleli_0310 EMBL AFM02797.1
OrganismFlexibacter litoralis (strain ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4) [Complete proteome] [HAMAP] EMBL AFM02797.1
Taxonomic identifier880071 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Cytophagia › Cytophagales › Cytophagaceae › Flexibacter ›

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. RuleBase RU004446

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. RuleBase RU004446

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Sequences

Sequence LengthMass (Da)Tools
I4AFR2 [UniParc].

Last modified September 5, 2012. Version 1.
Checksum: E78DCAD8DD593F20

FASTA42646,378
        10         20         30         40         50         60 
MSENIITIGN GKLNVPENPT LPFIEGDGIG ADIWKASQAV FDAAVEKAYD GKRKINWKEV 

        70         80         90        100        110        120 
LAGEKAFNAT GNWLPAETLE AFKKYLVGIK GPLTTPVGGG IRSLNVALRQ ELDLYACLRP 

       130        140        150        160        170        180 
VRYFDGVPSP VKRPELTNMV IFRENTEDIY AGIEYMAGTA EADKVKKFLI EEMAVKNIRF 

       190        200        210        220        230        240 
PETSSIGIKP VSKEGTERLV RSAIKYAIAQ KLPSVTLVHK GNIMKFTEGA FKTWGYELAE 

       250        260        270        280        290        300 
QEFGNETYTW QQYDRTKAAK GTEAADAEQK AALDSGKILV KDSIADAFLQ QILLRPSEYS 

       310        320        330        340        350        360 
VVATLNLNGD YISDALAAIV GGIGIAPGAN INYVTGTSIF EATHGTAPKY AGLDKVNPSS 

       370        380        390        400        410        420 
VILSGVMMFE YMGWQEAADL ITQGLEGAID SKHVTYDFER QMEGATLVSC SGFGNEIIKN 


MKPVTA

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References

[1]"The complete genome of Flexibacter litoralis DSM 6794."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Peters L., Ovchinnikova G., Lu M., Kyrpides N., Mavromatis K., Ivanova N., Brettin T., Detter J.C., Han C. expand/collapse author list , Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Spring S., Lang E., Kopitz M., Brambilla E., Klenk H.-P., Eisen J.A.
Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003345 Genomic DNA. Translation: AFM02797.1.
RefSeqYP_006432590.1. NC_018018.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFM02797; AFM02797; Fleli_0310.
GeneID13122775.
KEGGfli:Fleli_0310.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00031.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00183. prok_nadp_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI4AFR2_FLELS
AccessionPrimary (citable) accession number: I4AFR2
Entry history
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: April 3, 2013
This is version 7 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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