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I4AFR2

- I4AFR2_FLELS

UniProt

I4AFR2 - I4AFR2_FLELS

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Protein
Isocitrate dehydrogenase [NADP]
Gene
Fleli_0310
Organism
Flexibacter litoralis (strain ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciFLIT880071:GLDC-309-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Fleli_0310Imported
OrganismiFlexibacter litoralis (strain ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4)Imported
Taxonomic identifieri880071 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeFlexibacter
ProteomesiUP000006054: Chromosome

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I4AFR2-1 [UniParc]FASTAAdd to Basket

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MSENIITIGN GKLNVPENPT LPFIEGDGIG ADIWKASQAV FDAAVEKAYD    50
GKRKINWKEV LAGEKAFNAT GNWLPAETLE AFKKYLVGIK GPLTTPVGGG 100
IRSLNVALRQ ELDLYACLRP VRYFDGVPSP VKRPELTNMV IFRENTEDIY 150
AGIEYMAGTA EADKVKKFLI EEMAVKNIRF PETSSIGIKP VSKEGTERLV 200
RSAIKYAIAQ KLPSVTLVHK GNIMKFTEGA FKTWGYELAE QEFGNETYTW 250
QQYDRTKAAK GTEAADAEQK AALDSGKILV KDSIADAFLQ QILLRPSEYS 300
VVATLNLNGD YISDALAAIV GGIGIAPGAN INYVTGTSIF EATHGTAPKY 350
AGLDKVNPSS VILSGVMMFE YMGWQEAADL ITQGLEGAID SKHVTYDFER 400
QMEGATLVSC SGFGNEIIKN MKPVTA 426
Length:426
Mass (Da):46,378
Last modified:September 5, 2012 - v1
Checksum:iE78DCAD8DD593F20
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003345 Genomic DNA. Translation: AFM02797.1.
RefSeqiYP_006432590.1. NC_018018.1.

Genome annotation databases

EnsemblBacteriaiAFM02797; AFM02797; Fleli_0310.
GeneIDi13122775.
KEGGifli:Fleli_0310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003345 Genomic DNA. Translation: AFM02797.1 .
RefSeqi YP_006432590.1. NC_018018.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFM02797 ; AFM02797 ; Fleli_0310 .
GeneIDi 13122775.
KEGGi fli:Fleli_0310.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci FLIT880071:GLDC-309-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4.

Entry informationi

Entry nameiI4AFR2_FLELS
AccessioniPrimary (citable) accession number: I4AFR2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: October 16, 2013
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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