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I4AFR2

- I4AFR2_FLELS

UniProt

I4AFR2 - I4AFR2_FLELS

Protein

Isocitrate dehydrogenase [NADP]

Gene

Fleli_0310

Organism
Flexibacter litoralis (strain ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 10 (01 Oct 2014)
      Sequence version 1 (05 Sep 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciFLIT880071:GLDC-309-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Fleli_0310Imported
    OrganismiFlexibacter litoralis (strain ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4)Imported
    Taxonomic identifieri880071 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeFlexibacter
    ProteomesiUP000006054: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I4AFR2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSENIITIGN GKLNVPENPT LPFIEGDGIG ADIWKASQAV FDAAVEKAYD    50
    GKRKINWKEV LAGEKAFNAT GNWLPAETLE AFKKYLVGIK GPLTTPVGGG 100
    IRSLNVALRQ ELDLYACLRP VRYFDGVPSP VKRPELTNMV IFRENTEDIY 150
    AGIEYMAGTA EADKVKKFLI EEMAVKNIRF PETSSIGIKP VSKEGTERLV 200
    RSAIKYAIAQ KLPSVTLVHK GNIMKFTEGA FKTWGYELAE QEFGNETYTW 250
    QQYDRTKAAK GTEAADAEQK AALDSGKILV KDSIADAFLQ QILLRPSEYS 300
    VVATLNLNGD YISDALAAIV GGIGIAPGAN INYVTGTSIF EATHGTAPKY 350
    AGLDKVNPSS VILSGVMMFE YMGWQEAADL ITQGLEGAID SKHVTYDFER 400
    QMEGATLVSC SGFGNEIIKN MKPVTA 426
    Length:426
    Mass (Da):46,378
    Last modified:September 5, 2012 - v1
    Checksum:iE78DCAD8DD593F20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003345 Genomic DNA. Translation: AFM02797.1.
    RefSeqiYP_006432590.1. NC_018018.1.

    Genome annotation databases

    EnsemblBacteriaiAFM02797; AFM02797; Fleli_0310.
    GeneIDi13122775.
    KEGGifli:Fleli_0310.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003345 Genomic DNA. Translation: AFM02797.1 .
    RefSeqi YP_006432590.1. NC_018018.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFM02797 ; AFM02797 ; Fleli_0310 .
    GeneIDi 13122775.
    KEGGi fli:Fleli_0310.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci FLIT880071:GLDC-309-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4Imported.

    Entry informationi

    Entry nameiI4AFR2_FLELS
    AccessioniPrimary (citable) accession number: I4AFR2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 5, 2012
    Last sequence update: September 5, 2012
    Last modified: October 1, 2014
    This is version 10 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3