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I4AFK1

- I4AFK1_FLELS

UniProt

I4AFK1 - I4AFK1_FLELS

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Protein
Submitted name:

ATP-grasp enzyme, D-alanine-D-alanine ligase

Gene

Fleli_0247

Organism
Flexibacter litoralis (strain ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Binds 2 magnesium or manganese ions per subunit.SAAS annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. D-alanine-D-alanine ligase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciFLIT880071:GLDC-246-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-grasp enzyme, D-alanine-D-alanine ligaseImported
Gene namesi
Ordered Locus Names:Fleli_0247Imported
OrganismiFlexibacter litoralis (strain ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4)Imported
Taxonomic identifieri880071 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeFlexibacter
ProteomesiUP000006054: Chromosome

Subcellular locationi

Cytoplasm SAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

KOiK01921.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I4AFK1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFVVLISTHN FFFQDNNSLL MIKIGVFFGG VSREREISFS GAKTVSQTLN
60 70 80 90 100
RSLFEPVYIL VDSLGKFIKI NPVQFEHKAI SHFYPTQESI PEEYDEFSPV
110 120 130 140 150
YIETLENLTK EKHREIMEEV GTPISTENLS EHIDFALLML HGTFAEDGML
160 170 180 190 200
QGLFEWLQIP YSGCGIFSSS FSIDKHLQQV VNEKLNLGDN RKYQMIRKEE
210 220 230 240 250
WQKCDKKEFF EDLKSKLGLP IVIKAPYQGS SIGVSILKND NLEEFIKAVN
260 270 280 290 300
TSLFARQISK DEWTQLTMPQ RKEYVNVLMS LEKGIGLPII FEEKSLLGGN
310 320 330 340 350
LGEQIIYSPL KLIEKLNDFF SYSEENATLF SFESEDMVLF EECLSGKEFS
360 370 380 390 400
CGVIQNENLE VVALPPTEII TTTKVYDFEA KYLPNASQKR IPIDIPTDKI
410 420 430 440 450
IEIQEKCKAI FQTFKFDACA RIDGFYTDDN RIEIIDINTL PGMSPTSLIF
460 470 480 490 500
RQAAEVGFSP TDFMTYLVYQ SLNCRVHTAK RPYFFRNLFK KLESELLDSA
510 520 530 540 550
YHKKEKVAIF FDETIFDEAR KEYNSIASEG KQNPFCVFVK TENNQEVTLY
560 570 580 590 600
KLPVSFLLKP NIEEVIQNLE TELHPAISHT IEKAKELTDF FVKDFVSVPQ
610 620 630 640
KITLENLNDM TNDAVWLLRS PNNEDAAQSK LKRQLYEIGM AVVD
Length:644
Mass (Da):74,069
Last modified:September 5, 2012 - v1
Checksum:iD848A063EED8FB0E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003345 Genomic DNA. Translation: AFM02736.1.
RefSeqiWP_014796201.1. NC_018018.1.
YP_006432529.1. NC_018018.1.

Genome annotation databases

EnsemblBacteriaiAFM02736; AFM02736; Fleli_0247.
GeneIDi13122631.
KEGGifli:Fleli_0247.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003345 Genomic DNA. Translation: AFM02736.1 .
RefSeqi WP_014796201.1. NC_018018.1.
YP_006432529.1. NC_018018.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFM02736 ; AFM02736 ; Fleli_0247 .
GeneIDi 13122631.
KEGGi fli:Fleli_0247.

Phylogenomic databases

KOi K01921.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci FLIT880071:GLDC-246-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4Imported.

Entry informationi

Entry nameiI4AFK1_FLELS
AccessioniPrimary (citable) accession number: I4AFK1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: October 29, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3