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I4AFK1

- I4AFK1_FLELS

UniProt

I4AFK1 - I4AFK1_FLELS

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Protein
Submitted name:

ATP-grasp enzyme, D-alanine-D-alanine ligase

Gene
Fleli_0247
Organism
Flexibacter litoralis (strain ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.SAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.SAAS annotations

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. D-alanine-D-alanine ligase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotations, Peptidoglycan synthesisSAAS annotations

Keywords - Ligandi

ATP-bindingSAAS annotations, MagnesiumSAAS annotations, ManganeseSAAS annotations, Metal-bindingSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciFLIT880071:GLDC-246-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-grasp enzyme, D-alanine-D-alanine ligaseImported
Gene namesi
Ordered Locus Names:Fleli_0247Imported
OrganismiFlexibacter litoralis (strain ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4)Imported
Taxonomic identifieri880071 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeFlexibacter
ProteomesiUP000006054: Chromosome

Subcellular locationi

Cytoplasm By similarity SAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotations

Family & Domainsi

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

KOiK01921.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I4AFK1-1 [UniParc]FASTAAdd to Basket

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MFVVLISTHN FFFQDNNSLL MIKIGVFFGG VSREREISFS GAKTVSQTLN    50
RSLFEPVYIL VDSLGKFIKI NPVQFEHKAI SHFYPTQESI PEEYDEFSPV 100
YIETLENLTK EKHREIMEEV GTPISTENLS EHIDFALLML HGTFAEDGML 150
QGLFEWLQIP YSGCGIFSSS FSIDKHLQQV VNEKLNLGDN RKYQMIRKEE 200
WQKCDKKEFF EDLKSKLGLP IVIKAPYQGS SIGVSILKND NLEEFIKAVN 250
TSLFARQISK DEWTQLTMPQ RKEYVNVLMS LEKGIGLPII FEEKSLLGGN 300
LGEQIIYSPL KLIEKLNDFF SYSEENATLF SFESEDMVLF EECLSGKEFS 350
CGVIQNENLE VVALPPTEII TTTKVYDFEA KYLPNASQKR IPIDIPTDKI 400
IEIQEKCKAI FQTFKFDACA RIDGFYTDDN RIEIIDINTL PGMSPTSLIF 450
RQAAEVGFSP TDFMTYLVYQ SLNCRVHTAK RPYFFRNLFK KLESELLDSA 500
YHKKEKVAIF FDETIFDEAR KEYNSIASEG KQNPFCVFVK TENNQEVTLY 550
KLPVSFLLKP NIEEVIQNLE TELHPAISHT IEKAKELTDF FVKDFVSVPQ 600
KITLENLNDM TNDAVWLLRS PNNEDAAQSK LKRQLYEIGM AVVD 644
Length:644
Mass (Da):74,069
Last modified:September 5, 2012 - v1
Checksum:iD848A063EED8FB0E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003345 Genomic DNA. Translation: AFM02736.1.
RefSeqiWP_014796201.1. NC_018018.1.
YP_006432529.1. NC_018018.1.

Genome annotation databases

EnsemblBacteriaiAFM02736; AFM02736; Fleli_0247.
GeneIDi13122631.
KEGGifli:Fleli_0247.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003345 Genomic DNA. Translation: AFM02736.1 .
RefSeqi WP_014796201.1. NC_018018.1.
YP_006432529.1. NC_018018.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFM02736 ; AFM02736 ; Fleli_0247 .
GeneIDi 13122631.
KEGGi fli:Fleli_0247.

Phylogenomic databases

KOi K01921.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci FLIT880071:GLDC-246-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 2 hits.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4.

Entry informationi

Entry nameiI4AFK1_FLELS
AccessioniPrimary (citable) accession number: I4AFK1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: September 3, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3