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I4AFK1

- I4AFK1_FLELS

UniProt

I4AFK1 - I4AFK1_FLELS

Protein
Submitted name:

ATP-grasp enzyme, D-alanine-D-alanine ligase

Gene

Fleli_0247

Organism
Flexibacter litoralis (strain ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 12 (01 Oct 2014)
      Sequence version 1 (05 Sep 2012)
      Previous versions | rss
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    Functioni

    Cell wall formation.SAAS annotation

    Catalytic activityi

    ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.SAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. D-alanine-D-alanine ligase activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
    2. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseSAAS annotationImported

    Keywords - Biological processi

    Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciFLIT880071:GLDC-246-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ATP-grasp enzyme, D-alanine-D-alanine ligaseImported
    Gene namesi
    Ordered Locus Names:Fleli_0247Imported
    OrganismiFlexibacter litoralis (strain ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4)Imported
    Taxonomic identifieri880071 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCytophagaceaeFlexibacter
    ProteomesiUP000006054: Chromosome

    Subcellular locationi

    Cytoplasm SAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains ATP-grasp domain.SAAS annotation

    Phylogenomic databases

    KOiK01921.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view]
    PANTHERiPTHR23132. PTHR23132. 1 hit.
    PfamiPF07478. Dala_Dala_lig_C. 2 hits.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I4AFK1-1 [UniParc]FASTAAdd to Basket

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    MFVVLISTHN FFFQDNNSLL MIKIGVFFGG VSREREISFS GAKTVSQTLN    50
    RSLFEPVYIL VDSLGKFIKI NPVQFEHKAI SHFYPTQESI PEEYDEFSPV 100
    YIETLENLTK EKHREIMEEV GTPISTENLS EHIDFALLML HGTFAEDGML 150
    QGLFEWLQIP YSGCGIFSSS FSIDKHLQQV VNEKLNLGDN RKYQMIRKEE 200
    WQKCDKKEFF EDLKSKLGLP IVIKAPYQGS SIGVSILKND NLEEFIKAVN 250
    TSLFARQISK DEWTQLTMPQ RKEYVNVLMS LEKGIGLPII FEEKSLLGGN 300
    LGEQIIYSPL KLIEKLNDFF SYSEENATLF SFESEDMVLF EECLSGKEFS 350
    CGVIQNENLE VVALPPTEII TTTKVYDFEA KYLPNASQKR IPIDIPTDKI 400
    IEIQEKCKAI FQTFKFDACA RIDGFYTDDN RIEIIDINTL PGMSPTSLIF 450
    RQAAEVGFSP TDFMTYLVYQ SLNCRVHTAK RPYFFRNLFK KLESELLDSA 500
    YHKKEKVAIF FDETIFDEAR KEYNSIASEG KQNPFCVFVK TENNQEVTLY 550
    KLPVSFLLKP NIEEVIQNLE TELHPAISHT IEKAKELTDF FVKDFVSVPQ 600
    KITLENLNDM TNDAVWLLRS PNNEDAAQSK LKRQLYEIGM AVVD 644
    Length:644
    Mass (Da):74,069
    Last modified:September 5, 2012 - v1
    Checksum:iD848A063EED8FB0E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003345 Genomic DNA. Translation: AFM02736.1.
    RefSeqiWP_014796201.1. NC_018018.1.
    YP_006432529.1. NC_018018.1.

    Genome annotation databases

    EnsemblBacteriaiAFM02736; AFM02736; Fleli_0247.
    GeneIDi13122631.
    KEGGifli:Fleli_0247.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003345 Genomic DNA. Translation: AFM02736.1 .
    RefSeqi WP_014796201.1. NC_018018.1.
    YP_006432529.1. NC_018018.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFM02736 ; AFM02736 ; Fleli_0247 .
    GeneIDi 13122631.
    KEGGi fli:Fleli_0247.

    Phylogenomic databases

    KOi K01921.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci FLIT880071:GLDC-246-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view ]
    PANTHERi PTHR23132. PTHR23132. 1 hit.
    Pfami PF07478. Dala_Dala_lig_C. 2 hits.
    PF01820. Dala_Dala_lig_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4Imported.

    Entry informationi

    Entry nameiI4AFK1_FLELS
    AccessioniPrimary (citable) accession number: I4AFK1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 5, 2012
    Last sequence update: September 5, 2012
    Last modified: October 1, 2014
    This is version 12 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3