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I3ZVF3

- I3ZVF3_9EURY

UniProt

I3ZVF3 - I3ZVF3_9EURY

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Protein

Thymidine kinase

Gene

tdk

Organism
Thermococcus sp. CL1
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei92 – 921Proton acceptorUniRule annotation
Metal bindingi148 – 1481ZincUniRule annotation
Metal bindingi151 – 1511ZincUniRule annotation
Metal bindingi186 – 1861ZincUniRule annotation
Metal bindingi189 – 1891ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 208ATPUniRule annotation
Nucleotide bindingi91 – 944ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciTSP163003:GLMB-1530-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
ORF Names:CL1_1488Imported
OrganismiThermococcus sp. CL1Imported
Taxonomic identifieri163003 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000006064: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I3ZVF3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVHPGGFLEV ITGPMFAGKT TELIKRIERQ TFAKRKAALF KPAIDNRYSE
60 70 80 90 100
DEVVAHNGLR YEAFVVSTDE DGVRRIVEIT RKGNYDVIGI DEVQFFPMDI
110 120 130 140 150
VGALEELADE GVYVIASGLN LDFKAEPFPV TKELLVRADN IVYLTAVCTV
160 170 180 190
CGKPATRSQR LIDGKPAPRD SPVILVGGSE SYEARCRGHH FVP
Length:193
Mass (Da):21,353
Last modified:September 5, 2012 - v1
Checksum:iCBAC4866319E161E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003651 Genomic DNA. Translation: AFL95687.1.
RefSeqiWP_014789319.1. NC_018015.1.
YP_006425481.1. NC_018015.1.

Genome annotation databases

EnsemblBacteriaiAFL95687; AFL95687; CL1_1488.
GeneIDi13037892.
KEGGithm:CL1_1488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003651 Genomic DNA. Translation: AFL95687.1 .
RefSeqi WP_014789319.1. NC_018015.1.
YP_006425481.1. NC_018015.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFL95687 ; AFL95687 ; CL1_1488 .
GeneIDi 13037892.
KEGGi thm:CL1_1488.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci TSP163003:GLMB-1530-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of the Hyperthermophilic Archaeon Thermococcus sp. Strain CL1, Isolated from a Paralvinella sp. Polychaete Worm Collected from a Hydrothermal Vent."
    Jung J.H., Holden J.F., Seo D.H., Park K.H., Shin H., Ryu S., Lee J.H., Park C.S.
    J. Bacteriol. 194:4769-4770(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiI3ZVF3_9EURY
AccessioniPrimary (citable) accession number: I3ZVF3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: November 26, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3