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I3ZVF2

- I3ZVF2_9EURY

UniProt

I3ZVF2 - I3ZVF2_9EURY

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Protein

Ribulose bisphosphate carboxylase

Gene
rbcL, CL1_1487
Organism
Thermococcus sp. CL1
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase By similarity.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei163 – 1631Proton acceptor By similarityUniRule annotation
Binding sitei165 – 1651Substrate By similarityUniRule annotation
Metal bindingi189 – 1891Magnesium; via carbamate group By similarityUniRule annotation
Metal bindingi191 – 1911Magnesium By similarityUniRule annotation
Metal bindingi192 – 1921Magnesium By similarityUniRule annotation
Active sitei281 – 2811Proton acceptor By similarityUniRule annotation
Binding sitei282 – 2821Substrate By similarityUniRule annotation
Binding sitei314 – 3141Substrate By similarityUniRule annotation
Sitei322 – 3221Transition state stabilizer By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. oxidoreductase activity Source: UniProtKB-KW
  3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. carbon fixation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciTSP163003:GLMB-1529-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotation
ORF Names:CL1_1487Imported
OrganismiThermococcus sp. CL1Imported
Taxonomic identifieri163003 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000006064: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei189 – 1891N6-carboxylysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI3ZVF2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni367 – 3693Substrate binding By similarityUniRule annotation
Regioni389 – 3924Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK01601.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01133. RuBisCO_L_type3.
InterProiIPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

Sequencei

Sequence statusi: Complete.

I3ZVF2-1 [UniParc]FASTAAdd to Basket

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MVEKFDRIYD YYVDKDYEPN RKRDIIAVFR ITPAEGYSIE AVAGGVAAES    50
STGTWTTLYN WYEEERWADL SAKAFDFHDM GDGSWIVKIA YPFHAFEEAN 100
LPGLLASIAG NVFGMKRAKA LRLEDLYFPE KLIREFDGPA FGIEGVRKML 150
DIKDRPIYGV VPKPKVGYSP EEFEKLAYDL LSNGADYMKD DENLTSPWYN 200
RFEERAEIIA RIIDRVENET GEKKTWFANI TANLPEMEER IEILADLGLK 250
HAMVDVVITG WGALQYIRDL AADYGLAIHG HRAMHAAFTR NPYHGISMFV 300
LAKLYRLIGI DQLHVGTAGA GKLEGGKWDV IQNARVLREE TYRPDEGDVF 350
HLEQKFYGIK AAFPTSSGGL HPGNLPPVIE ALGTDIVLQL GGGTLGHPDG 400
PAAGARAVRQ AIDAIMQGIP LDEYAKTHKE LARALEKWGH VTPV 444
Length:444
Mass (Da):49,679
Last modified:September 5, 2012 - v1
Checksum:i43CE0E4FD39BCDF0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003651 Genomic DNA. Translation: AFL95686.1.
RefSeqiWP_014789318.1. NC_018015.1.
YP_006425480.1. NC_018015.1.

Genome annotation databases

EnsemblBacteriaiAFL95686; AFL95686; CL1_1487.
GeneIDi13037891.
KEGGithm:CL1_1487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003651 Genomic DNA. Translation: AFL95686.1 .
RefSeqi WP_014789318.1. NC_018015.1.
YP_006425480.1. NC_018015.1.

3D structure databases

ProteinModelPortali I3ZVF2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFL95686 ; AFL95686 ; CL1_1487 .
GeneIDi 13037891.
KEGGi thm:CL1_1487.

Phylogenomic databases

KOi K01601.

Enzyme and pathway databases

BioCyci TSP163003:GLMB-1529-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPi MF_01133. RuBisCO_L_type3.
InterProi IPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of the Hyperthermophilic Archaeon Thermococcus sp. Strain CL1, Isolated from a Paralvinella sp. Polychaete Worm Collected from a Hydrothermal Vent."
    Jung J.H., Holden J.F., Seo D.H., Park K.H., Shin H., Ryu S., Lee J.H., Park C.S.
    J. Bacteriol. 194:4769-4770(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiI3ZVF2_9EURY
AccessioniPrimary (citable) accession number: I3ZVF2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: September 3, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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