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I3ZUL6 (I3ZUL6_9EURY) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase RuleBase RU000617 HAMAP-Rule MF_00407

EC=6.5.1.1 RuleBase RU000617 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig HAMAP-Rule MF_00407
ORF Names:CL1_1197 EMBL AFL95400.1
OrganismThermococcus sp. CL1 [Complete proteome] EMBL AFL95400.1
Taxonomic identifier163003 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

Protein attributes

Sequence length559 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407 RuleBase RU004196

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2491N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2471ATP By similarity HAMAP-Rule MF_00407
Binding site2541ATP By similarity HAMAP-Rule MF_00407
Binding site2691ATP By similarity HAMAP-Rule MF_00407
Binding site2991ATP By similarity HAMAP-Rule MF_00407
Binding site3391ATP By similarity HAMAP-Rule MF_00407
Binding site4141ATP By similarity HAMAP-Rule MF_00407
Binding site4201ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
I3ZUL6 [UniParc].

Last modified September 5, 2012. Version 1.
Checksum: 934B59576B22B39B

FASTA55963,488
        10         20         30         40         50         60 
MKYSELTELY RRLEKTTLKT LKTRFVAEFL RKTPDDVLEV VPYLILGKVF PDWDERELGV 

        70         80         90        100        110        120 
GEKLLIKSVS IATGVSEREI ENSVKDTGDL GESVALALKK KKQRSFFSQP LTIKRVYDTF 

       130        140        150        160        170        180 
VKIAEAQGEG SQDRKMKYLA NLFMDAKPEE GKYLARTVLG TMRTGVAEGI LRDAIAEAFK 

       190        200        210        220        230        240 
VKPELVERAY MLTSDFGHVA KIAKLEGNEG LSRVRIQVGK PIRPMLAQNA ASVKEALAEM 

       250        260        270        280        290        300 
GGKAAFEIKY DGARVQVHKD GDRVVIYSRR LENVTRSIPE IVRAVRESLK AEKAIVEGEL 

       310        320        330        340        350        360 
VAVGEGGKPR PFQYVLRRFR RKYNIEEMIE KIPLELNLFD VLYVDGEGLI DTPFSERREK 

       370        380        390        400        410        420 
LEEIISPGER IRLAEQLVTK SAEEAEAFYK KALELGHEGL MAKRLDSVYE PGNRGKKWLK 

       430        440        450        460        470        480 
IKPTMEDLDL VIIGAEWGEG RRAHLLGSFL VAAFDPHSGE FVPVGKVGSG FTDEDLAEFT 

       490        500        510        520        530        540 
KMLKPLIVRE EGKYVEIEPK VVIQVTYQEI QRSPKYESGF ALRFPRYVAL REDKSPEEAD 

       550 
TIERIAQLYE FQERFKAKR 

« Hide

References

[1]"Complete Genome Sequence of the Hyperthermophilic Archaeon Thermococcus sp. Strain CL1, Isolated from a Paralvinella sp. Polychaete Worm Collected from a Hydrothermal Vent."
Jung J.H., Holden J.F., Seo D.H., Park K.H., Shin H., Ryu S., Lee J.H., Park C.S.
J. Bacteriol. 194:4769-4770(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]Jung J.-H., Lee J.-H., Holden J.F., Seo D.-H., Shin H., Ryu S., Park C.-S.
Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003651 Genomic DNA. Translation: AFL95400.1.
RefSeqYP_006425194.1. NC_018015.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFL95400; AFL95400; CL1_1197.
GeneID13037587.
KEGGthm:CL1_1197.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK10747.

Enzyme and pathway databases

BioCycTSP163003:GLMB-1228-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI3ZUL6_9EURY
AccessionPrimary (citable) accession number: I3ZUL6
Entry history
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: June 11, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)