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Protein

Isocitrate dehydrogenase [NADP]

Gene

Terro_0475

Organism
Terriglobus roseus (strain DSM 18391 / NRRL B-41598 / KBS 63)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 magnesium or manganese ion per subunit.
  • Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciTROS926566:GLM7-475-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Terro_0475Imported
OrganismiTerriglobus roseus (strain DSM 18391 / NRRL B-41598 / KBS 63)Imported
Taxonomic identifieri926566 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeTerriglobus
ProteomesiUP000006056 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.
OMAiRDWGYEL.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I3ZC48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTSYNGIEV PVDGKAITYT NGAYSVPDNP IVPFIEGDGA GRDIWKNARK
60 70 80 90 100
VLDAAVEKSY GGTKKVAWYE ILAGEKAYGL TQNWLPDDTV QACIDFRVSI
110 120 130 140 150
KGPLTTPIGG GIRSLNVTLR QTMDLYQCIR PVKHYPGVPS PVINADDVDV
160 170 180 190 200
VIFRENTEDI YAGIEFKAGS PEEAKLREFV NTQLLANTKK QLRSDGGIGI
210 220 230 240 250
KPITEMASKR LVRAAIQYAV DHGRKVMSIV HKGNIQKFTE GAFREWGYEV
260 270 280 290 300
AVTEFRDKIV TERESWILGA LDKDPNTPPE AIAKLVEPGL KFAPPSFEQK
310 320 330 340 350
IIAEVKDVIA AIGATHGNGA WKKLILVNDR ICDAMFQDLL LKPQEYDVLA
360 370 380 390 400
TTNLNGDYLS DAAAAQVGGL GIAPGSNIGD GYAVFEATHG TAPRLADQDV
410 420 430 440 450
VNPGSVILSG AMLLQLIGWK EAADLVEKAM EKTISQKYVT VDFAKSMQGA
460
TQVGTTAFSD RVIENM
Length:466
Mass (Da):50,664
Last modified:September 5, 2012 - v1
Checksum:iC96EC81D58EA55DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003379 Genomic DNA. Translation: AFL86816.1.
RefSeqiWP_014784385.1. NC_018014.1.

Genome annotation databases

EnsemblBacteriaiAFL86816; AFL86816; Terro_0475.
KEGGitrs:Terro_0475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003379 Genomic DNA. Translation: AFL86816.1.
RefSeqiWP_014784385.1. NC_018014.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFL86816; AFL86816; Terro_0475.
KEGGitrs:Terro_0475.

Phylogenomic databases

KOiK00031.
OMAiRDWGYEL.

Enzyme and pathway databases

BioCyciTROS926566:GLM7-475-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 18391 / NRRL B-41598 / KBS 63Imported.

Entry informationi

Entry nameiI3ZC48_TERRK
AccessioniPrimary (citable) accession number: I3ZC48
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: July 22, 2015
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.