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I3ZC48

- I3ZC48_TERRK

UniProt

I3ZC48 - I3ZC48_TERRK

Protein

Isocitrate dehydrogenase [NADP]

Gene

Terro_0475

Organism
Terriglobus roseus (strain DSM 18391 / NRRL B-41598 / KBS 63)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 11 (01 Oct 2014)
      Sequence version 1 (05 Sep 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciTROS926566:GLM7-475-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Terro_0475Imported
    OrganismiTerriglobus roseus (strain DSM 18391 / NRRL B-41598 / KBS 63)Imported
    Taxonomic identifieri926566 [NCBI]
    Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeTerriglobus
    ProteomesiUP000006056: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.
    OMAiCLRPIRY.

    Family and domain databases

    Gene3Di3.40.718.10. 2 hits.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I3ZC48-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQTSYNGIEV PVDGKAITYT NGAYSVPDNP IVPFIEGDGA GRDIWKNARK    50
    VLDAAVEKSY GGTKKVAWYE ILAGEKAYGL TQNWLPDDTV QACIDFRVSI 100
    KGPLTTPIGG GIRSLNVTLR QTMDLYQCIR PVKHYPGVPS PVINADDVDV 150
    VIFRENTEDI YAGIEFKAGS PEEAKLREFV NTQLLANTKK QLRSDGGIGI 200
    KPITEMASKR LVRAAIQYAV DHGRKVMSIV HKGNIQKFTE GAFREWGYEV 250
    AVTEFRDKIV TERESWILGA LDKDPNTPPE AIAKLVEPGL KFAPPSFEQK 300
    IIAEVKDVIA AIGATHGNGA WKKLILVNDR ICDAMFQDLL LKPQEYDVLA 350
    TTNLNGDYLS DAAAAQVGGL GIAPGSNIGD GYAVFEATHG TAPRLADQDV 400
    VNPGSVILSG AMLLQLIGWK EAADLVEKAM EKTISQKYVT VDFAKSMQGA 450
    TQVGTTAFSD RVIENM 466
    Length:466
    Mass (Da):50,664
    Last modified:September 5, 2012 - v1
    Checksum:iC96EC81D58EA55DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003379 Genomic DNA. Translation: AFL86816.1.
    RefSeqiYP_006420151.1. NC_018014.1.

    Genome annotation databases

    EnsemblBacteriaiAFL86816; AFL86816; Terro_0475.
    GeneIDi13039341.
    KEGGitrs:Terro_0475.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003379 Genomic DNA. Translation: AFL86816.1 .
    RefSeqi YP_006420151.1. NC_018014.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFL86816 ; AFL86816 ; Terro_0475 .
    GeneIDi 13039341.
    KEGGi trs:Terro_0475.

    Phylogenomic databases

    KOi K00031.
    OMAi CLRPIRY.

    Enzyme and pathway databases

    BioCyci TROS926566:GLM7-475-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 2 hits.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 18391 / NRRL B-41598 / KBS 63Imported.

    Entry informationi

    Entry nameiI3ZC48_TERRK
    AccessioniPrimary (citable) accession number: I3ZC48
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 5, 2012
    Last sequence update: September 5, 2012
    Last modified: October 1, 2014
    This is version 11 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3