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I3ZC48

- I3ZC48_TERRK

UniProt

I3ZC48 - I3ZC48_TERRK

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Protein

Isocitrate dehydrogenase [NADP]

Gene

Terro_0475

Organism
Terriglobus roseus (strain DSM 18391 / NRRL B-41598 / KBS 63)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciTROS926566:GLM7-475-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Terro_0475Imported
OrganismiTerriglobus roseus (strain DSM 18391 / NRRL B-41598 / KBS 63)Imported
Taxonomic identifieri926566 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeTerriglobus
ProteomesiUP000006056: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.
OMAiCLRPIRY.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I3ZC48-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQTSYNGIEV PVDGKAITYT NGAYSVPDNP IVPFIEGDGA GRDIWKNARK
60 70 80 90 100
VLDAAVEKSY GGTKKVAWYE ILAGEKAYGL TQNWLPDDTV QACIDFRVSI
110 120 130 140 150
KGPLTTPIGG GIRSLNVTLR QTMDLYQCIR PVKHYPGVPS PVINADDVDV
160 170 180 190 200
VIFRENTEDI YAGIEFKAGS PEEAKLREFV NTQLLANTKK QLRSDGGIGI
210 220 230 240 250
KPITEMASKR LVRAAIQYAV DHGRKVMSIV HKGNIQKFTE GAFREWGYEV
260 270 280 290 300
AVTEFRDKIV TERESWILGA LDKDPNTPPE AIAKLVEPGL KFAPPSFEQK
310 320 330 340 350
IIAEVKDVIA AIGATHGNGA WKKLILVNDR ICDAMFQDLL LKPQEYDVLA
360 370 380 390 400
TTNLNGDYLS DAAAAQVGGL GIAPGSNIGD GYAVFEATHG TAPRLADQDV
410 420 430 440 450
VNPGSVILSG AMLLQLIGWK EAADLVEKAM EKTISQKYVT VDFAKSMQGA
460
TQVGTTAFSD RVIENM
Length:466
Mass (Da):50,664
Last modified:September 5, 2012 - v1
Checksum:iC96EC81D58EA55DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003379 Genomic DNA. Translation: AFL86816.1.
RefSeqiYP_006420151.1. NC_018014.1.

Genome annotation databases

EnsemblBacteriaiAFL86816; AFL86816; Terro_0475.
GeneIDi13039341.
KEGGitrs:Terro_0475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003379 Genomic DNA. Translation: AFL86816.1 .
RefSeqi YP_006420151.1. NC_018014.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFL86816 ; AFL86816 ; Terro_0475 .
GeneIDi 13039341.
KEGGi trs:Terro_0475.

Phylogenomic databases

KOi K00031.
OMAi CLRPIRY.

Enzyme and pathway databases

BioCyci TROS926566:GLM7-475-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 2 hits.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 18391 / NRRL B-41598 / KBS 63Imported.

Entry informationi

Entry nameiI3ZC48_TERRK
AccessioniPrimary (citable) accession number: I3ZC48
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: October 29, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3