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I3Z1W1

- I3Z1W1_BELBD

UniProt

I3Z1W1 - I3Z1W1_BELBD

Protein

Thymidine kinase

Gene

tdk

Organism
Belliella baltica (strain DSM 15883 / CIP 108006 / LMG 21964 / BA134)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 14 (01 Oct 2014)
      Sequence version 1 (05 Sep 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei97 – 971Proton acceptorUniRule annotation
    Metal bindingi153 – 1531ZincUniRule annotation
    Metal bindingi156 – 1561ZincUniRule annotation
    Metal bindingi185 – 1851ZincUniRule annotation
    Metal bindingi188 – 1881ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi24 – 318ATPUniRule annotation
    Nucleotide bindingi96 – 994ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciBBAL866536:GL8V-572-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:Belba_0572Imported
    OrganismiBelliella baltica (strain DSM 15883 / CIP 108006 / LMG 21964 / BA134)Imported
    Taxonomic identifieri866536 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCyclobacteriaceaeBelliella
    ProteomesiUP000006050: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I3Z1W1-1 [UniParc]FASTAAdd to Basket

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    MFIEPFISIK NKKDKKGHIE VICGSMFSGK TEELIRRLNR ALIAKQKVEI    50
    FKPSIDKRYH ELDVVSHNEN AIRSTPVNFA EDILLLAGDC DVVGIDEVQF 100
    FDNHIVHIAN VLANGGKRVI LAGLDMDFEG KAFEPMPQLL AIAEYVTKVH 150
    AICMKCGDLA SYSYRLSDTK DKVMLGEKDS YEARCRKCFY EEKN 194
    Length:194
    Mass (Da):22,019
    Last modified:September 5, 2012 - v1
    Checksum:i9E3BABC8C2E98A16
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003281 Genomic DNA. Translation: AFL83229.1.
    RefSeqiWP_014771242.1. NC_018010.1.
    YP_006405984.1. NC_018010.1.

    Genome annotation databases

    EnsemblBacteriaiAFL83229; AFL83229; Belba_0572.
    GeneIDi13054998.
    KEGGibbd:Belba_0572.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003281 Genomic DNA. Translation: AFL83229.1 .
    RefSeqi WP_014771242.1. NC_018010.1.
    YP_006405984.1. NC_018010.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFL83229 ; AFL83229 ; Belba_0572 .
    GeneIDi 13054998.
    KEGGi bbd:Belba_0572.

    Phylogenomic databases

    KOi K00857.

    Enzyme and pathway databases

    BioCyci BBAL866536:GL8V-572-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 15883 / CIP 108006 / LMG 21964 / BA134Imported.

    Entry informationi

    Entry nameiI3Z1W1_BELBD
    AccessioniPrimary (citable) accession number: I3Z1W1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 5, 2012
    Last sequence update: September 5, 2012
    Last modified: October 1, 2014
    This is version 14 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3