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Protein

Thymidine kinase

Gene

tdk

Organism
Belliella baltica (strain DSM 15883 / CIP 108006 / LMG 21964 / BA134)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971Proton acceptorUniRule annotation
Metal bindingi153 – 1531ZincUniRule annotation
Metal bindingi156 – 1561ZincUniRule annotation
Metal bindingi185 – 1851ZincUniRule annotation
Metal bindingi188 – 1881ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318ATPUniRule annotation
Nucleotide bindingi96 – 994ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciBBAL866536:GL8V-572-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Belba_0572Imported
OrganismiBelliella baltica (strain DSM 15883 / CIP 108006 / LMG 21964 / BA134)Imported
Taxonomic identifieri866536 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesCytophagiaCytophagalesCyclobacteriaceaeBelliella
ProteomesiUP000006050 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I3Z1W1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIEPFISIK NKKDKKGHIE VICGSMFSGK TEELIRRLNR ALIAKQKVEI
60 70 80 90 100
FKPSIDKRYH ELDVVSHNEN AIRSTPVNFA EDILLLAGDC DVVGIDEVQF
110 120 130 140 150
FDNHIVHIAN VLANGGKRVI LAGLDMDFEG KAFEPMPQLL AIAEYVTKVH
160 170 180 190
AICMKCGDLA SYSYRLSDTK DKVMLGEKDS YEARCRKCFY EEKN
Length:194
Mass (Da):22,019
Last modified:September 5, 2012 - v1
Checksum:i9E3BABC8C2E98A16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003281 Genomic DNA. Translation: AFL83229.1.
RefSeqiWP_014771242.1. NC_018010.1.
YP_006405984.1. NC_018010.1.

Genome annotation databases

EnsemblBacteriaiAFL83229; AFL83229; Belba_0572.
KEGGibbd:Belba_0572.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003281 Genomic DNA. Translation: AFL83229.1.
RefSeqiWP_014771242.1. NC_018010.1.
YP_006405984.1. NC_018010.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFL83229; AFL83229; Belba_0572.
KEGGibbd:Belba_0572.

Phylogenomic databases

KOiK00857.

Enzyme and pathway databases

BioCyciBBAL866536:GL8V-572-MONOMER.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15883 / CIP 108006 / LMG 21964 / BA134Imported.

Entry informationi

Entry nameiI3Z1W1_BELBD
AccessioniPrimary (citable) accession number: I3Z1W1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: April 29, 2015
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.