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Protein

Thymidine kinase

Gene

tdk

Organism
Aequorivita sublithincola (strain DSM 14238 / LMG 21431 / ACAM 643 / 9-3)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei94Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 28ATPUniRule annotation8
Nucleotide bindingi93 – 96ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Aeqsu_1052Imported
OrganismiAequorivita sublithincola (strain DSM 14238 / LMG 21431 / ACAM 643 / 9-3)Imported
Taxonomic identifieri746697 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeAequorivita
Proteomesi
  • UP000006049 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.
OMAiVITGPMY.
OrthoDBiPOG091H0659.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

I3YU83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLENTVNQK EQFGWIEVIS GSMFSGKSEE LIRRLKRAKF ARQKVEIFTP
60 70 80 90 100
SIDTRYAEDA VTSHDSNQIR STPVPAAANI PILADNCDVV GIDEAQFFDD
110 120 130 140 150
EIVKVCNDLA NRGVRVIVAG LDMDYKGNPF GPMPALMATA EYVTKVHAIC
160 170 180 190 200
TRTGNLAHYS YRKAKSEALV LLGETEEYEP LSRAAFFKAH LRDKVVKLEV
210
KEAEEINNEK AAEKTGKQA
Length:219
Mass (Da):24,430
Last modified:September 5, 2012 - v1
Checksum:i178DA99D30B34F67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003280 Genomic DNA. Translation: AFL80551.1.
RefSeqiWP_014781809.1. NC_018013.1.

Genome annotation databases

EnsemblBacteriaiAFL80551; AFL80551; Aeqsu_1052.
KEGGiasl:Aeqsu_1052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003280 Genomic DNA. Translation: AFL80551.1.
RefSeqiWP_014781809.1. NC_018013.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFL80551; AFL80551; Aeqsu_1052.
KEGGiasl:Aeqsu_1052.

Phylogenomic databases

KOiK00857.
OMAiVITGPMY.
OrthoDBiPOG091H0659.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiI3YU83_AEQSU
AccessioniPrimary (citable) accession number: I3YU83
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: May 10, 2017
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.