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Protein

Alanine racemase

Gene

Alfi_0326

Organism
Alistipes finegoldii (strain DSM 17242 / JCM 16770 / AHN 2437 / CCUG 46020 / CIP 107999)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Alfi_0326)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei460Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei558SubstrateUniRule annotation1
Active sitei684Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei733Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Alfi_0326Imported
OrganismiAlistipes finegoldii (strain DSM 17242 / JCM 16770 / AHN 2437 / CCUG 46020 / CIP 107999)Imported
Taxonomic identifieri679935 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesRikenellaceaeAlistipes
Proteomesi
  • UP000006052 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei460N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliI3YIB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini663 – 790Ala_racemase_CInterPro annotationAdd BLAST128

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiMVKAFAY.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
3.40.1190.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PF01225. Mur_ligase. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

I3YIB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYRLSRIAA ICGGKFSGCD SEVRSVVTDS RSLSCELGCR PMFVAMRGAN
60 70 80 90 100
HDSHDFIADM QSRGVRAFLV ERGVEASSCT GECGFVQVDN AIEALQRLAA
110 120 130 140 150
YHRAQFRGTV VGITGSNGKT VIKEWIAEEL PEGMKYYRSP KSYNSQLGVP
160 170 180 190 200
LSVLMLEGDE ELAIFEAGIS KPGEMERLER IIRPDAVIFT SIGDAHQENF
210 220 230 240 250
INLEQKCDEK MILARSASKI IYHSYYEPLG RMVAAHFADR RPVDAASYPE
260 270 280 290 300
VPESVIGNAA SRRNAQIVEA FCDAMRYPAP SFAGAPSVAM RLEVKEGIND
310 320 330 340 350
SILINDAYNL DLNSLALALD YLHSVALNRR RTLVLSDISQ SGLSDDELYS
360 370 380 390 400
RVAGMVARAG IDFLIGIGPR LKRYAALFAC DKEFFTATDE CVARINRDAV
410 420 430 440 450
AGRAILLKGA RDFRFEKLVH LLSRKSHTTV LEVDLDAMIH NLNYFRSKLS
460 470 480 490 500
FGTRLVAMVK AGSYGAGDFE VAQMLQHQGV DYLAVAFADE GVLLRERGIS
510 520 530 540 550
MPIVVLNADA DSFDVMIANR LEPEIYSFHS LGAFADAVTH AGESRYPIHV
560 570 580 590 600
KLDTGMHRLG FVEQEIAQLC ATLAATPQVK AASVFSHLNC ADMPEEDAYT
610 620 630 640 650
RAQIALYDRM SAQLAASLPY PVIRHTANSA AIERFPEAQF DMCRLGLGLY
660 670 680 690 700
GFGFRHNDAL RPVSTLKTRI VQIKRLPAGD AVGYGRAGKL TRPTTTATIP
710 720 730 740 750
IGYADGLDRH LGCGRWSVLV AGQPAPIIGR VCMDSCMIDI TDIPGVKEGD
760 770 780 790
EVSVFSPVPG NDLETMARVL DTISYEIMTS VSGRVKRIYL KE
Length:792
Mass (Da):86,894
Last modified:September 5, 2012 - v1
Checksum:iC8A9011A0CEFD5F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003274 Genomic DNA. Translation: AFL76728.1.
RefSeqiWP_014774519.1. NC_018011.1.

Genome annotation databases

EnsemblBacteriaiAFL76728; AFL76728; Alfi_0326.
KEGGiafd:Alfi_0326.
PATRICifig|679935.3.peg.308.

Similar proteinsi

Entry informationi

Entry nameiI3YIB0_ALIFI
AccessioniPrimary (citable) accession number: I3YIB0
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: September 27, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported