UniProtKB - I3Y991 (I3Y991_THIV6)
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Protein
Ribulose bisphosphate carboxylase large chain
Gene
cbbL
Organism
Thiocystis violascens (strain ATCC 17096 / DSM 198 / 6111) (Chromatium violascens)
Status
Functioni
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation
Miscellaneous
The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel".UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
Catalytic activityi
2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation
Cofactori
Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 115 | Substrate; in homodimeric partnerUniRule annotation | 1 | |
Binding sitei | 165 | SubstrateUniRule annotation | 1 | |
Active sitei | 167 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 169 | SubstrateUniRule annotation | 1 | |
Metal bindingi | 193 | Magnesium; via carbamate groupUniRule annotation | 1 | |
Metal bindingi | 195 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 196 | MagnesiumUniRule annotation | 1 | |
Active sitei | 286 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 287 | SubstrateUniRule annotation | 1 | |
Binding sitei | 319 | SubstrateUniRule annotation | 1 | |
Sitei | 326 | Transition state stabilizerUniRule annotation | 1 | |
Binding sitei | 371 | SubstrateUniRule annotation | 1 |
GO - Molecular functioni
- magnesium ion binding Source: UniProtKB-UniRule
- monooxygenase activity Source: UniProtKB-KW
- ribulose-bisphosphate carboxylase activity Source: UniProtKB-UniRule
GO - Biological processi
- reductive pentose-phosphate cycle Source: UniProtKB-KW
Keywordsi
Molecular function | LyaseUniRule annotationImported, MonooxygenaseUniRule annotation, Oxidoreductase |
Biological process | Calvin cycleUniRule annotation, Carbon dioxide fixationUniRule annotation, PhotosynthesisUniRule annotation |
Ligand | MagnesiumUniRule annotation, Metal-bindingUniRule annotation |
Enzyme and pathway databases
BioCyci | TVIO765911:G1H0L-1551-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Ribulose bisphosphate carboxylase large chainUniRule annotation (EC:4.1.1.39UniRule annotation)Short name: RuBisCO large subunitUniRule annotation |
Gene namesi | Name:cbbLUniRule annotation Ordered Locus Names:Thivi_1570Imported |
Organismi | Thiocystis violascens (strain ATCC 17096 / DSM 198 / 6111) (Chromatium violascens)Imported |
Taxonomic identifieri | 765911 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Chromatiaceae › Thiocystis › |
Proteomesi |
|
PTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 193 | N6-carboxylysineUniRule annotation | 1 |
Interactioni
Subunit structurei
Heterohexadecamer of 8 large chains and 8 small chains.UniRule annotation
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 136 | RuBisCO_large_NInterPro annotationAdd BLAST | 121 | |
Domaini | 146 – 454 | RuBisCO_largeInterPro annotationAdd BLAST | 309 |
Sequence similaritiesi
Phylogenomic databases
KOi | K01601 |
OMAi | EYRETYW |
OrthoDBi | POG091H14UZ |
Family and domain databases
Gene3Di | 3.20.20.1101 hit 3.30.70.1501 hit |
HAMAPi | MF_01338 RuBisCO_L_type1, 1 hit |
InterProi | View protein in InterPro IPR033966 RuBisCO IPR020878 RuBisCo_large_chain_AS IPR000685 RuBisCO_lsu_C IPR036376 RuBisCO_lsu_C_sf IPR017443 RuBisCO_lsu_fd_N IPR036422 RuBisCO_lsu_N_sf IPR020888 RuBisCO_lsuI |
Pfami | View protein in Pfam PF00016 RuBisCO_large, 1 hit PF02788 RuBisCO_large_N, 1 hit |
SFLDi | SFLDS00014 RuBisCO, 1 hit |
SUPFAMi | SSF51649 SSF51649, 1 hit SSF54966 SSF54966, 1 hit |
PROSITEi | View protein in PROSITE PS00157 RUBISCO_LARGE, 1 hit |
i Sequence
Sequence statusi: Complete.
I3Y991-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKTYSAGVK EYRETYWMPD YKPKETDLLA CFKITPQAGV PREEAAAAVA
60 70 80 90 100
AESSTGTWTT VWTDLLTDLD HYKGRAYAIE DVPGDDTCYY AFIAYPIDLF
110 120 130 140 150
EEGSVVNVFT SLVGNVFGFK AVRALRLEDV RFPIAYVMTC NGPPHGIQVE
160 170 180 190 200
RDMMNKYGRP LLGCTIKPKL GLSAKNYGRA VYECLRGGLD FTKDDENVNS
210 220 230 240 250
QPFMRWRQRF DFVIDAIDKA ERETGERKGH YLNVTAPTPE EMYKRAEHAK
260 270 280 290 300
EIGAPIIMHD YITGGFCANT GLAQWCRDNG MLLHIHRAMH AVLDRNPHHG
310 320 330 340 350
IHFRVLAKIL RLSGGDHLHS GTVVGKLEGD REATLGWIDI MRDSFIKEDR
360 370 380 390 400
SRGIFFDQDW GSMPGVFPVA SGGIHVWHMP ALVTIFGDDS VLQFGGGTLG
410 420 430 440 450
HPWGNAAGAA ANRVALEACV QARNEGVAIE KEGKEVLTNA AKNSPELKVA
460 470
METWKEIKFE FDTVDKLDVA HK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP003154 Genomic DNA Translation: AFL73559.1 |
RefSeqi | WP_014778025.1, NC_018012.1 |
Genome annotation databases
EnsemblBacteriai | AFL73559; AFL73559; Thivi_1570 |
KEGGi | tvi:Thivi_1570 |
Similar proteinsi
Entry informationi
Entry namei | I3Y991_THIV6 | |
Accessioni | I3Y991Primary (citable) accession number: I3Y991 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 5, 2012 |
Last sequence update: | September 5, 2012 | |
Last modified: | February 28, 2018 | |
This is version 37 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |