cbbL

Functionⁱ

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel".UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityⁱ

2 3-phospho-D-glycerate + 2 H⁺ = D-ribulose 1,5-bisphosphate + CO₂ + H₂O.UniRule annotation

3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O₂.UniRule annotation

Cofactorⁱ

Mg²⁺UniRule annotationNote: Binds 1 Mg²⁺ ion per subunit.UniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	115	Substrate; in homodimeric partnerUniRule annotation	1
Binding siteⁱ	165	SubstrateUniRule annotation	1
Active siteⁱ	167	Proton acceptorUniRule annotation	1
Binding siteⁱ	169	SubstrateUniRule annotation	1
Metal bindingⁱ	193	Magnesium; via carbamate groupUniRule annotation	1
Metal bindingⁱ	195	MagnesiumUniRule annotation	1
Metal bindingⁱ	196	MagnesiumUniRule annotation	1
Active siteⁱ	286	Proton acceptorUniRule annotation	1
Binding siteⁱ	287	SubstrateUniRule annotation	1
Binding siteⁱ	319	SubstrateUniRule annotation	1
Siteⁱ	326	Transition state stabilizerUniRule annotation	1
Binding siteⁱ	371	SubstrateUniRule annotation	1

GO - Molecular functionⁱ

magnesium ion binding Source: UniProtKB-UniRule
monooxygenase activity Source: UniProtKB-KW
ribulose-bisphosphate carboxylase activity Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

reductive pentose-phosphate cycle Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	LyaseUniRule annotationImported, MonooxygenaseUniRule annotation, Oxidoreductase
Biological process	Calvin cycleUniRule annotation, Carbon dioxide fixationUniRule annotation, PhotosynthesisUniRule annotation
Ligand	MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCycⁱ	TVIO765911:G1H0L-1551-MONOMER

BioCycⁱ

TVIO765911:G1H0L-1551-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ribulose bisphosphate carboxylase large chainUniRule annotation (EC:4.1.1.39UniRule annotation) Short name: RuBisCO large subunitUniRule annotation
Gene namesⁱ	Name:cbbLUniRule annotation Ordered Locus Names:Thivi_1570Imported
Organismⁱ	Thiocystis violascens (strain ATCC 17096 / DSM 198 / 6111) (Chromatium violascens)Imported
Taxonomic identifierⁱ	765911 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Chromatiaceae › Thiocystis › Thiocystis violascens
Proteomesⁱ	UP000006062 Componentⁱ: Chromosome

PTM / Processingⁱ

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	193	N6-carboxylysineUniRule annotation		1

Interactionⁱ

Subunit structureⁱ

Heterohexadecamer of 8 large chains and 8 small chains.UniRule annotation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	I3Y991
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	16 – 136	RuBisCO_large_NInterPro annotationAdd BLAST		121
Domainⁱ	146 – 454	RuBisCO_largeInterPro annotationAdd BLAST		309

Sequence similaritiesⁱ

Belongs to the RuBisCO large chain family. Type I subfamily.UniRule annotation

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K01601
OMAⁱ	EYRETYW
Database of Orthologous Groups More...OrthoDBⁱ	POG091H14UZ

Family and domain databases

Gene3Dⁱ	3.20.20.1101 hit 3.30.70.1501 hit
HAMAPⁱ	MF_01338 RuBisCO_L_type1, 1 hit
InterProⁱ	View protein in InterPro IPR033966 RuBisCO IPR020878 RuBisCo_large_chain_AS IPR000685 RuBisCO_lsu_C IPR036376 RuBisCO_lsu_C_sf IPR017443 RuBisCO_lsu_fd_N IPR036422 RuBisCO_lsu_N_sf IPR020888 RuBisCO_lsuI
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00016 RuBisCO_large, 1 hit PF02788 RuBisCO_large_N, 1 hit
SFLDⁱ	SFLDS00014 RuBisCO, 1 hit
SUPFAMⁱ	SSF51649 SSF51649, 1 hit SSF54966 SSF54966, 1 hit
PROSITEⁱ	View protein in PROSITE PS00157 RUBISCO_LARGE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

I3Y991-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAKTYSAGVK EYRETYWMPD YKPKETDLLA CFKITPQAGV PREEAAAAVA 
        60         70         80         90        100
AESSTGTWTT VWTDLLTDLD HYKGRAYAIE DVPGDDTCYY AFIAYPIDLF 
       110        120        130        140        150
EEGSVVNVFT SLVGNVFGFK AVRALRLEDV RFPIAYVMTC NGPPHGIQVE 
       160        170        180        190        200
RDMMNKYGRP LLGCTIKPKL GLSAKNYGRA VYECLRGGLD FTKDDENVNS 
       210        220        230        240        250
QPFMRWRQRF DFVIDAIDKA ERETGERKGH YLNVTAPTPE EMYKRAEHAK 
       260        270        280        290        300
EIGAPIIMHD YITGGFCANT GLAQWCRDNG MLLHIHRAMH AVLDRNPHHG 
       310        320        330        340        350
IHFRVLAKIL RLSGGDHLHS GTVVGKLEGD REATLGWIDI MRDSFIKEDR 
       360        370        380        390        400
SRGIFFDQDW GSMPGVFPVA SGGIHVWHMP ALVTIFGDDS VLQFGGGTLG 
       410        420        430        440        450
HPWGNAAGAA ANRVALEACV QARNEGVAIE KEGKEVLTNA AKNSPELKVA 
       460        470 
METWKEIKFE FDTVDKLDVA HK

Length:472

Mass (Da):52,594

Last modified:September 5, 2012 - v1

Checksum:ⁱ14C66F85CA42A001

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP003154 Genomic DNA Translation: AFL73559.1
NCBI Reference Sequences More...RefSeqⁱ	WP_014778025.1, NC_018012.1

Genome annotation databases

EnsemblBacteriaⁱ	AFL73559; AFL73559; Thivi_1570
KEGGⁱ	tvi:Thivi_1570

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
I3Y991	Q603Q7 A0A1F6U3U3 A0A1F6TNW8 A0A1B4VGN2 A0A0K2QJE6 A0A024FCF1 A0A2N6B3B9 A0A1G0FA07 A0A257U7I9 A0A0R0LRY0 +24	Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) Candidatus Muproteobacteria bacterium RIFCSPHIGHO2_02_FULL_65_16 Candidatus Muproteobacteria bacterium RIFCSPHIGHO2_01_FULL_65_16 Sulfurifustis variabilis Methylocaldum marinum Rhizobiales bacterium Gammaproteobacteria bacterium RBG_16_57_12 Ferrovum sp. 37-45-19 Ferrovum sp. JA12 Beggiatoa sp. IS2 And more	473	UniRef90_Q603Q7	Cluster: Ribulose bisphosphate carboxylase large chain	35

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
I3Y991	A4YQD3 H0SZM2 A5EF40 A0A292Z1I5 A0A219AUE9 A0A1U7DJ29 A0A2M9DAL6 A0A1I1XWC8 A0A1E4PHI6 A0A1Y6CV88 +16208	Bradyrhizobium sp. (strain ORS 278) Bradyrhizobium sp. STM 3809 Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182) Pseudonocardia sp. N23 Loktanella sp. 22II-4b Xuhuaishuia manganoxidans Brevirhabdus pacifica Roseivivax sediminis Pseudonocardia sp. SCN 73-27 Methylomagnum ishizawai And more	479	UniRef50_A4YQD3	Cluster: Ribulose bisphosphate carboxylase large chain 2	16,219

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP003154 Genomic DNA Translation: AFL73559.1
NCBI Reference Sequences More...RefSeqⁱ	WP_014778025.1, NC_018012.1

3D structure databases

ProteinModelPortalⁱ	I3Y991
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AFL73559; AFL73559; Thivi_1570
KEGGⁱ	tvi:Thivi_1570

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K01601
OMAⁱ	EYRETYW
Database of Orthologous Groups More...OrthoDBⁱ	POG091H14UZ

Enzyme and pathway databases

BioCycⁱ	TVIO765911:G1H0L-1551-MONOMER

BioCycⁱ

TVIO765911:G1H0L-1551-MONOMER

Family and domain databases

Gene3Dⁱ	3.20.20.1101 hit 3.30.70.1501 hit
HAMAPⁱ	MF_01338 RuBisCO_L_type1, 1 hit
InterProⁱ	View protein in InterPro IPR033966 RuBisCO IPR020878 RuBisCo_large_chain_AS IPR000685 RuBisCO_lsu_C IPR036376 RuBisCO_lsu_C_sf IPR017443 RuBisCO_lsu_fd_N IPR036422 RuBisCO_lsu_N_sf IPR020888 RuBisCO_lsuI
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00016 RuBisCO_large, 1 hit PF02788 RuBisCO_large_N, 1 hit
SFLDⁱ	SFLDS00014 RuBisCO, 1 hit
SUPFAMⁱ	SSF51649 SSF51649, 1 hit SSF54966 SSF54966, 1 hit
PROSITEⁱ	View protein in PROSITE PS00157 RUBISCO_LARGE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	I3Y991_THIV6
Accessionⁱ	I3Y991Primary (citable) accession number: I3Y991
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 5, 2012
	Last sequence update:	September 5, 2012
	Last modified:	February 28, 2018
	This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - I3Y991 (I3Y991_THIV6)

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Ribulose bisphosphate carboxylase large chain

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Caution

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ