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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Sulfurospirillum barnesii (strain ATCC 700032 / DSM 10660 / SES-3)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+SAAS annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSBAR760154:G1H5M-1217-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotationSAAS annotation (EC:6.3.2.4UniRule annotationSAAS annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:Sulba_1214Imported
OrganismiSulfurospirillum barnesii (strain ATCC 700032 / DSM 10660 / SES-3)Imported
Taxonomic identifieri760154 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeSulfurospirillum
Proteomesi
  • UP000006176 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 327ATP-graspInterPro annotationAdd BLAST195

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01921
OMAiRCDFFVI
OrthoDBiPOG091H06GK

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

I3XX34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIAVLFGAQ SFEHEISVVS AIALKKVLKS EIVYIFCDYE RNFYLIPTDT
60 70 80 90 100
INAKRFSSGA YKKDKSLVLK QGGFFAQKMF GEEKVAFDVL INLVHGRDGE
110 120 130 140 150
DGKLSSLLEF FAIPYIGPRI EGSCISYNKL FTKLYAKEVG VDVLDYQVLH
160 170 180 190 200
KESKDDIRIA YPFIVKPLRL GSSIGIGIVK DEKELSYALD VAFEFDDTVL
210 220 230 240 250
IEPFMQGVKE YNLAGCKTDG FIFSIIEEPQ KEEFLDFDKK YLDFSRTKRV
260 270 280 290 300
TEAHLDVKIQ EKIREAFVKL YDPLFLGALI RCDFFVIDET IYLNEINPIP
310 320 330 340
GSMANYLFDD FDTIITSLAQ YLPRTTTVMK AYHYIHSIQA AKGK
Length:344
Mass (Da):39,275
Last modified:September 5, 2012 - v1
Checksum:i80BE4FCCDBB7AA8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003333 Genomic DNA Translation: AFL68508.1
RefSeqiWP_014769387.1, NC_018002.1

Genome annotation databases

EnsemblBacteriaiAFL68508; AFL68508; Sulba_1214
KEGGisba:Sulba_1214
PATRICifig|760154.4.peg.1219

Similar proteinsi

Entry informationi

Entry nameiI3XX34_SULBS
AccessioniPrimary (citable) accession number: I3XX34
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: March 28, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health