ID I3XCX5_SINF2 Unreviewed; 865 AA. AC I3XCX5; DT 05-SEP-2012, integrated into UniProtKB/TrEMBL. DT 05-SEP-2012, sequence version 1. DT 27-MAR-2024, entry version 69. DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727}; DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727}; DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943}; GN Name=ykoU3 {ECO:0000313|EMBL:AFL53731.1}; GN ORFNames=USDA257_c52060 {ECO:0000313|EMBL:AFL53731.1}; OS Sinorhizobium fredii (strain USDA 257). OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales; OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium. OX NCBI_TaxID=1185652 {ECO:0000313|EMBL:AFL53731.1, ECO:0000313|Proteomes:UP000006180}; RN [1] {ECO:0000313|EMBL:AFL53731.1, ECO:0000313|Proteomes:UP000006180} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=USDA 257 {ECO:0000313|EMBL:AFL53731.1, RC ECO:0000313|Proteomes:UP000006180}; RX PubMed=22843606; DOI=10.1128/JB.00966-12; RA Schuldes J., Rodriguez Orbegoso M., Schmeisser C., Krishnan H.B., RA Daniel R., Streit W.R.; RT "Complete genome sequence of the broad-host-range strain Sinorhizobium RT fredii USDA257."; RL J. Bacteriol. 194:4483-4483(2012). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho- CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003}; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|ARBA:ARBA00001936}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP003563; AFL53731.1; -; Genomic_DNA. DR RefSeq; WP_014765846.1; NC_018000.1. DR AlphaFoldDB; I3XCX5; -. DR STRING; 1185652.USDA257_c52060; -. DR KEGG; sfd:USDA257_c52060; -. DR PATRIC; fig|1185652.3.peg.5402; -. DR eggNOG; COG1793; Bacteria. DR eggNOG; COG3285; Bacteria. DR HOGENOM; CLU_008325_0_1_5; -. DR Proteomes; UP000006180; Chromosome. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC. DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW. DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW. DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1. DR CDD; cd07971; OBF_DNA_ligase_LigD; 1. DR CDD; cd04862; PaeLigD_Pol_like; 1. DR Gene3D; 3.30.1490.70; -; 1. DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1. DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1. DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1. DR InterPro; IPR012309; DNA_ligase_ATP-dep_C. DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent. DR InterPro; IPR014146; LigD_ligase_dom. DR InterPro; IPR014144; LigD_PE_domain. DR InterPro; IPR014145; LigD_pol_dom. DR InterPro; IPR012340; NA-bd_OB-fold. DR InterPro; IPR014143; NHEJ_ligase_prk. DR InterPro; IPR033651; PaeLigD_Pol-like. DR NCBIfam; TIGR02777; LigD_PE_dom; 1. DR NCBIfam; TIGR02778; ligD_pol; 1. DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1. DR NCBIfam; TIGR02776; NHEJ_ligase_prk; 1. DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1. DR PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1. DR Pfam; PF04679; DNA_ligase_A_C; 1. DR Pfam; PF01068; DNA_ligase_A_M; 1. DR Pfam; PF13298; LigD_N; 1. DR Pfam; PF21686; LigD_Prim-Pol; 1. DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1. DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1. DR PROSITE; PS50160; DNA_LIGASE_A3; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW DNA damage {ECO:0000256|ARBA:ARBA00022763}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932}; KW Exonuclease {ECO:0000256|ARBA:ARBA00022839}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AFL53731.1}; KW Manganese {ECO:0000256|ARBA:ARBA00023211}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268}; KW Nuclease {ECO:0000256|ARBA:ARBA00022722}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 328..452 FT /note="ATP-dependent DNA ligase family profile" FT /evidence="ECO:0000259|PROSITE:PS50160" FT REGION 1..31 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 214..240 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 540..573 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 8..29 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 865 AA; 95657 MW; 0B1F1E741DC7B5AA CRC64; MAARSEPLSE YNRRRDFSKT REPKGAVART HPGQKRFLVQ KHDATRLHYD FRLEWEGVLK SWAVTRGPSL NPEDKRLAIR TEDHPLAYGD FEGTIPEGEY GGGTVMLWDT GWWEPEDDPE KGLKKGKLAF RLHGSRMKGG WALVRMRPRD GEKRESWLLV KQDDDVASED GESLIKQHVV SARTGRTMDE IAEGRGEKRA RVWHSNKSTA ANLNAGAVSQ DEGRSKRRAR KSSVKPPAFR PPQLATLVTK APAGDDWLNE AKFDGYRLIA AVGGGIARCY TRNGLDWTEK FPTIAAALAE LDCDSALIDG EVVALADQGS NFSALQKALR TGASMRFYAF DLIELDEKDL SRRPLVERKE KLAALLDSLG TTATIQYSEH VRGNGEHILA AICKAGQEGI IAKEAKAPYR SGRTRSWLKV KCTKRQEFVI GGYTPSTKKG RAFASLLLGT FEGGKLIYRG GVGTGFGEKV MEELAAAFAK RQRPTSPFDQ VPRERSRDAV WLKPDLVAEV DFAEFTADGH IRHGSFEGLR EDREAKTVKL ETAKPTDAEP GAAKGKSSAK TRTASPTKGD ADILGVHISH PDRILFEGQG ITKIDLARYY AVVAERMLPF AADHPVSLVR CPQGGQRQCF FQKHANEGFP EAIREVPITE SSGETENYMY VHDAKGLVAA VQMGTLEFHI WGATIDRLEK PDRLVFDLDP DPSVDFATVK AAATTLRDEL AEIGLKTVAM VTGGKGVHVI VPLRPHAEWD EAKGFAKRLA QTFAERDPEH FVATMSKAKR KGRIFIDWLR NDRGATAIAP YSTRARAGGP VATPVSWDEL EALDAANTFH IADIIERIEA GTDPWREIGE IKQSLTKKML NSTIS //