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Protein

Alanine racemase

Gene

alr

Organism
Sinorhizobium fredii USDA 257
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr), Alanine racemase (dadX), Alanine racemase (USDA257_c02520)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei162SubstrateUniRule annotation1
Active sitei284Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei343Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
ORF Names:USDA257_c08530Imported
OrganismiSinorhizobium fredii USDA 257Imported
Taxonomic identifieri1185652 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000006180 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliI3X0N9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini263 – 400Ala_racemase_CInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01775.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

I3X0N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKPFAASGA WMYCSRYRPC KSSPMHSPEF LAASNRLTID LTALADNWRA
60 70 80 90 100
MNERSGKARA AAVLKANAYG IGVAHAAPAL CAAGARDFFV ADAEEGAELR
110 120 130 140 150
PLLPDARIYI LAGMWPGNEE LFFANDLVPI INSEEQLAVF MATLSERGEH
160 170 180 190 200
PCVLHVDTGM NRLGLSVEEA IALAHDPARP ASFSPVLVMS HLACGDDPKH
210 220 230 240 250
PMNLYQLQRF REVTAAFEGV PASLANSGGV FLGEDYHFDL TRPGIAVYGG
260 270 280 290 300
EAVNDAINPM KPVVTAEARI LQLRTVPSGG TASYGASARF TRDSRIATVA
310 320 330 340 350
IGYADGYHRS VSGGGVTLRQ AMPSGAFGFL HGRKVPHVGR VTMDLSLFDV
360 370 380 390 400
TDLPERAVRA GDYIELFGRN VAIDDVARAG GTIGYELLTS LGHRYCRTYA

GGA
Length:403
Mass (Da):43,142
Last modified:September 5, 2012 - v1
Checksum:i46E052A347E2183B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003563 Genomic DNA. Translation: AFL49445.1.

Genome annotation databases

EnsemblBacteriaiAFL49445; AFL49445; USDA257_c08530.
KEGGisfd:USDA257_c08530.
PATRICifig|1185652.3.peg.886.

Similar proteinsi

Entry informationi

Entry nameiI3X0N9_RHIFR
AccessioniPrimary (citable) accession number: I3X0N9
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: September 27, 2017
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported