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Protein

Alanine racemase

Gene

USDA257_c02520

Organism
Sinorhizobium fredii USDA 257
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr), Alanine racemase (dadX), Alanine racemase (USDA257_c02520)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei51Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei150SubstrateUniRule annotation1
Active sitei272Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei320Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSFRE1185652:G13FV-252-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:USDA257_c02520Imported
OrganismiSinorhizobium fredii USDA 257Imported
Taxonomic identifieri1185652 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000006180 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliI3WYZ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini251 – 377Ala_racemase_CInterPro annotationAdd BLAST127

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01775
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

I3WYZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRHALHIQG REAEAGAGAS GYLTIDLAAL RRNYQKLSAA VAPATVAAVV
60 70 80 90 100
KADAYGLGAQ QVSKALHAQG CRQFFVAHLA EAIELRSLLP NDTQIAVLNG
110 120 130 140 150
LQPGAEITCA KANIVPVLNS LEQFRRWSFT AQKLGRVLPT VLQFDTGMSR
160 170 180 190 200
LGVPLQERTA LAAVLKDCRS IEILFIMSHL ACADEVDNKQ NADQLAEMRL
210 220 230 240 250
IAAEFADLDV CFANSGGVFL GRDYHGALSR PGIALYGGAP IAGRPNPIEP
260 270 280 290 300
VVRLDVAVIQ TRTVPAGTRV GYGGAHVTSA ETRLATIAAG YADGLPRSLS
310 320 330 340 350
DRGAVFFDGV RLPIVGRVSM DSITVDITAL PEGTLSLGSL VEVLGPHQTL
360 370
EDVAEAAGTI SYEILTGLGR RYERRYR
Length:377
Mass (Da):40,135
Last modified:September 5, 2012 - v1
Checksum:iE152582DDBC2CF8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003563 Genomic DNA Translation: AFL48850.1
RefSeqiWP_014761047.1, NC_018000.1

Genome annotation databases

EnsemblBacteriaiAFL48850; AFL48850; USDA257_c02520
KEGGisfd:USDA257_c02520
PATRICifig|1185652.3.peg.263

Similar proteinsi

Entry informationi

Entry nameiI3WYZ4_RHIFR
AccessioniPrimary (citable) accession number: I3WYZ4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: February 28, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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