ID   I3WKG9_BIFBI            Unreviewed;       865 AA.
AC   I3WKG9;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   Name=nedA {ECO:0000313|EMBL:AFL05382.1};
GN   ORFNames=BBB_1792 {ECO:0000313|EMBL:AFL05382.1};
OS   Bifidobacterium bifidum BGN4.
OC   Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC   Bifidobacteriaceae; Bifidobacterium.
OX   NCBI_TaxID=484020 {ECO:0000313|EMBL:AFL05382.1, ECO:0000313|Proteomes:UP000006173};
RN   [1] {ECO:0000313|EMBL:AFL05382.1, ECO:0000313|Proteomes:UP000006173}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGN4 {ECO:0000313|EMBL:AFL05382.1,
RC   ECO:0000313|Proteomes:UP000006173};
RX   PubMed=22887663; DOI=10.1128/JB.00988-12;
RA   Yu D.S., Jeong H., Lee D.H., Kwon S.K., Song J.Y., Kim B.K., Park M.S.,
RA   Ji G.E., Oh T.K., Kim J.F.;
RT   "Complete Genome Sequence of the Probiotic Bacterium Bifidobacterium
RT   bifidum Strain BGN4.";
RL   J. Bacteriol. 194:4757-4758(2012).
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DR   EMBL; CP001361; AFL05382.1; -; Genomic_DNA.
DR   AlphaFoldDB; I3WKG9; -.
DR   KEGG; bbf:BBB_1792; -.
DR   PATRIC; fig|484020.3.peg.1778; -.
DR   HOGENOM; CLU_340318_0_0_11; -.
DR   Proteomes; UP000006173; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.40.3630; -; 1.
DR   InterPro; IPR018905; A-galactase_NEW3.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF10633; NPCBM_assoc; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Glycosidase {ECO:0000313|EMBL:AFL05382.1};
KW   Hydrolase {ECO:0000313|EMBL:AFL05382.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006173};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        840..859
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          264..545
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
FT   DOMAIN          602..662
FT                   /note="Alpha-galactosidase NEW3"
FT                   /evidence="ECO:0000259|Pfam:PF10633"
FT   REGION          797..837
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        799..821
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   865 AA;  90150 MW;  D828F55761DA21A7 CRC64;
     MVRKPCRPIG GTAVGAQSRD PALHRRGTHM VRSTKPSLLR RLGALVAAAA MLVVLPAGVS
     TASAASDDTD MLTVTMTRTD ALGDEVYVGD TLTYSFTNTN NTSSAFTAFP AESNLSGVLT
     TGTPNCRYEN LAGGASYPCS TASHTITADD LTAGSFTPRT VWKATSDRGG TQVLQDNIVS
     TGDTVTVKEG KRPDPATIPT DRADGEAVRL ATARQNLGTE CYRIPALAEA PNGWILAAFD
     QRPNTAMANG SGVKCWDAPQ PNSIVQRISK DGGKSWTPIQ YVAQGKNAPD RYGYSDPSYV
     VDEETGEIFL FFVHSYNKGF ADSQLGVDES NRNVLHAVVV SSKDNGETWS KPRDITADIT
     KGYENEWKSR FATSGAGIQL KYGKYKGRLI QQYAVGRTTG SNAAVSVYSD DHGKTWQAGN
     PVTGMLMDEN KVVELSDGRV MLNSRPGNGS GYRRVAISKD GGMNYGTVKN ETQLPDPNNN
     AHITRAFPNA PEGSAKAKVL LYSSPRANNE GRANGVVRIS LDDGTTWSSG KLYKEGSMAY
     SVITALSGAA GGGYGLLYEG AWVTGGGIDS HDIMYTHISM DWLGYLSATA DDVTASVEEG
     ASTVDVTVPV SNVGSVDYTG VTVTPADLPT GWSASPVNVG ALAGGASKDV TVTVNVPATA
     TKDDVAKIVL RVTGTSAANA NATTGFDGSI TVNVTEKSEP DPEPEPTITG VSAVTSQAGV
     KVGDVFDASK VSVTAAMSDG SSKALAAGEY SLSAVDADGK AVDLAEPFAA AGVVTVTVSV
     PVEGANPLTA SFTIDVAEKS VDPEPKPEPE PKPEPEKPAG PKVDVPTEQP GLSKTGASTA
     GMSIVFVLLA LSGVAALSLR RRSVH
//