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Protein
Submitted name:

Lysine-specific demethylase 2A

Gene

KDM2A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri547 – 593CXXC-typePROSITE-ProRule annotationAdd BLAST47

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseImported, Transferase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Lysine-specific demethylase 2AImported
Submitted name:
N-terminus deleted lysine-specific demethylase 2AImported
Gene namesi
Name:KDM2AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000173120.14
HGNCiHGNC:13606 KDM2A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173120

PTM / Processingi

Proteomic databases

PeptideAtlasiI3VM54
PRIDEiI3VM54

Expressioni

Gene expression databases

BgeeiENSG00000173120
ExpressionAtlasiI3VM54 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 299JmjCInterPro annotationAdd BLAST169
Domaini547 – 593CXXC-typeInterPro annotationAdd BLAST47
Domaini600 – 661PHD-typeInterPro annotationAdd BLAST62

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri547 – 593CXXC-typePROSITE-ProRule annotationAdd BLAST47

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1633 Eukaryota
KOG1947 Eukaryota
ENOG410XQXU LUCA
GeneTreeiENSGT00550000074396

Family and domain databases

Gene3Di3.30.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001810 F-box_dom
IPR003347 JmjC_dom
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00646 F-box, 1 hit
PF02373 JmjC, 1 hit
PF16866 PHD_4, 1 hit
PF02008 zf-CXXC, 1 hit
SMARTiView protein in SMART
SM00558 JmjC, 1 hit
SM00367 LRR_CC, 3 hits
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit
PS51058 ZF_CXXC, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequencei

Sequence statusi: Complete.

I3VM54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRRYEDDGI SDDEIEGKRT FDLEEKLHTN KYNANFVTFM EGKDFNVEYI
60 70 80 90 100
QRGGLRDPLI FKNSDGLGIK MPDPDFTVND VKMCVGSRRM VDVMDVNTQK
110 120 130 140 150
GIEMTMAQWT RYYETPEEER EKLYNVISLE FSHTRLENMV QRPSTVDFID
160 170 180 190 200
WVDNMWPRHL KESQTESTNA ILEMQYPKVQ KYCLMSVRGC YTDFHVDFGG
210 220 230 240 250
TSVWYHIHQG GKVFWLIPPT AHNLELYENW LLSGKQGDIF LGDRVSDCQR
260 270 280 290 300
IELKQGYTFV IPSGWIHAVY TPTDTLVFGG NFLHSFNIPM QLKIYNIEDR
310 320 330 340 350
TRVPNKFRYP FYYEMCWYVL ERYVYCITNR SHLTKEFQKE SLSMDLELNG
360 370 380 390 400
LESGNGDEEA VDREPRRLSS RRSVLTSPVA NGVNLDYDGL GKTCRSLPSL
410 420 430 440 450
KKTLAGDSSS DCSRGSHNGQ VWDPQCAPRK DRQVHLTHFE LEGLRCLVDK
460 470 480 490 500
LESLPLHKKC VPTGIEDEDA LIADVKILLE ELANSDPKLA LTGVPIVQWP
510 520 530 540 550
KRDKLKFPTR PKVRVPTIPI TKPHTMKPAP RLTPVRPAAA SPIVSGARRR
560 570 580 590 600
RVRCRKCKAC VQGECGVCHY CRDMKKFGGP GRMKQSCVLR QCLAPRLPHS
610 620 630 640 650
VTCSLCGEVD QNEETQDFEK KLMECCICNE IVHPGCLQMD GEGLLNEELP
660 670 680 690 700
NCWECPKCYQ EDSSEKAQKR KMEESDEEAV QAKVLRPLRS CDEPLTPPPH
710 720 730 740 750
SPTSMLQLIH DPVSPRGMVT RSSPGAGPSD HHSASRDERF KRRQLLRLQA
760 770 780 790 800
TERTMVREKE NNPSGKKELS EVEKAKIRGS YLTVTLQRPT KELHGTSIVP
810 820 830 840 850
KLQAITASSA NLRHSPRVLV QHCPARTPQR GDEEGLGGEE EEEEEEEEED
860 870 880 890 900
DSAEEGGAAR LNGRGSWAQD GDESWMQREV WMSVFRYLSR RELCECMRVC
910 920 930 940 950
KTWYKWCCDK RLWTKIDLSR CKAIVPQALS GIIKRQPVSL DLSWTNISKK
960 970 980 990 1000
QLTWLVNRLP GLKDLLLAGC SWSAVSALST SSCPLLRTLD LRWAVGIKDP
1010 1020 1030 1040 1050
QIRDLLTPPA DKPGQDNRSK LRNMTDFRLA GLDITDATLR LIIRHMPLLS
1060 1070 1080 1090 1100
RLDLSHCSHL TDQSSNLLTA VGSSTRYSLT ELNMAGCNKL TDQTLIYLRR
1110 1120 1130 1140
IANVTLIDLR GCKQITRKAC EHFISDLSIN SLYCLSDEKL IQKIS
Length:1,145
Mass (Da):130,660
Last modified:September 5, 2012 - v1
Checksum:i8CA12C114C847472
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000729 Genomic DNA No translation available.
AP001885 Genomic DNA No translation available.
JQ710742 mRNA Translation: AFK81541.1
RefSeqiXP_016872880.1, XM_017017391.1
XP_016872881.1, XM_017017392.1
UniGeneiHs.124147

Genome annotation databases

EnsembliENST00000308783; ENSP00000309302; ENSG00000173120
GeneIDi22992
UCSCiuc031qbr.2 human

Similar proteinsi

Entry informationi

Entry nameiI3VM54_HUMAN
AccessioniPrimary (citable) accession number: I3VM54
Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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