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Protein
Submitted name:

Lysine-specific demethylase 2A

Gene

KDM2A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseImported, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Lysine-specific demethylase 2AImported
Submitted name:
N-terminus deleted lysine-specific demethylase 2AImported
Gene namesi
Name:KDM2AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:13606. KDM2A.

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173120.

PTM / Processingi

Proteomic databases

EPDiI3VM54.
PeptideAtlasiI3VM54.
PRIDEiI3VM54.

Expressioni

Gene expression databases

BgeeiENSG00000173120.
ExpressionAtlasiI3VM54. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000432786.

Structurei

3D structure databases

ProteinModelPortaliI3VM54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 299JmjCInterPro annotationAdd BLAST169
Domaini547 – 593CXXC-typeInterPro annotationAdd BLAST47
Domaini600 – 661PHD-typeInterPro annotationAdd BLAST62

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG1633. Eukaryota.
KOG1947. Eukaryota.
ENOG410XQXU. LUCA.
GeneTreeiENSGT00550000074396.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR003347. JmjC_dom.
IPR032675. L_dom-like.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
IPR019786. Zinc_finger_PHD-type_CS.
IPR002857. Znf_CXXC.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF02373. JmjC. 1 hit.
PF16866. PHD_4. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
SM00367. LRR_CC. 3 hits.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51184. JMJC. 1 hit.
PS51058. ZF_CXXC. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I3VM54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRRYEDDGI SDDEIEGKRT FDLEEKLHTN KYNANFVTFM EGKDFNVEYI
60 70 80 90 100
QRGGLRDPLI FKNSDGLGIK MPDPDFTVND VKMCVGSRRM VDVMDVNTQK
110 120 130 140 150
GIEMTMAQWT RYYETPEEER EKLYNVISLE FSHTRLENMV QRPSTVDFID
160 170 180 190 200
WVDNMWPRHL KESQTESTNA ILEMQYPKVQ KYCLMSVRGC YTDFHVDFGG
210 220 230 240 250
TSVWYHIHQG GKVFWLIPPT AHNLELYENW LLSGKQGDIF LGDRVSDCQR
260 270 280 290 300
IELKQGYTFV IPSGWIHAVY TPTDTLVFGG NFLHSFNIPM QLKIYNIEDR
310 320 330 340 350
TRVPNKFRYP FYYEMCWYVL ERYVYCITNR SHLTKEFQKE SLSMDLELNG
360 370 380 390 400
LESGNGDEEA VDREPRRLSS RRSVLTSPVA NGVNLDYDGL GKTCRSLPSL
410 420 430 440 450
KKTLAGDSSS DCSRGSHNGQ VWDPQCAPRK DRQVHLTHFE LEGLRCLVDK
460 470 480 490 500
LESLPLHKKC VPTGIEDEDA LIADVKILLE ELANSDPKLA LTGVPIVQWP
510 520 530 540 550
KRDKLKFPTR PKVRVPTIPI TKPHTMKPAP RLTPVRPAAA SPIVSGARRR
560 570 580 590 600
RVRCRKCKAC VQGECGVCHY CRDMKKFGGP GRMKQSCVLR QCLAPRLPHS
610 620 630 640 650
VTCSLCGEVD QNEETQDFEK KLMECCICNE IVHPGCLQMD GEGLLNEELP
660 670 680 690 700
NCWECPKCYQ EDSSEKAQKR KMEESDEEAV QAKVLRPLRS CDEPLTPPPH
710 720 730 740 750
SPTSMLQLIH DPVSPRGMVT RSSPGAGPSD HHSASRDERF KRRQLLRLQA
760 770 780 790 800
TERTMVREKE NNPSGKKELS EVEKAKIRGS YLTVTLQRPT KELHGTSIVP
810 820 830 840 850
KLQAITASSA NLRHSPRVLV QHCPARTPQR GDEEGLGGEE EEEEEEEEED
860 870 880 890 900
DSAEEGGAAR LNGRGSWAQD GDESWMQREV WMSVFRYLSR RELCECMRVC
910 920 930 940 950
KTWYKWCCDK RLWTKIDLSR CKAIVPQALS GIIKRQPVSL DLSWTNISKK
960 970 980 990 1000
QLTWLVNRLP GLKDLLLAGC SWSAVSALST SSCPLLRTLD LRWAVGIKDP
1010 1020 1030 1040 1050
QIRDLLTPPA DKPGQDNRSK LRNMTDFRLA GLDITDATLR LIIRHMPLLS
1060 1070 1080 1090 1100
RLDLSHCSHL TDQSSNLLTA VGSSTRYSLT ELNMAGCNKL TDQTLIYLRR
1110 1120 1130 1140
IANVTLIDLR GCKQITRKAC EHFISDLSIN SLYCLSDEKL IQKIS
Length:1,145
Mass (Da):130,660
Last modified:September 5, 2012 - v1
Checksum:i8CA12C114C847472
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000729 Genomic DNA. No translation available.
AP001885 Genomic DNA. No translation available.
JQ710742 mRNA. Translation: AFK81541.1.
RefSeqiXP_016872880.1. XM_017017391.1.
XP_016872881.1. XM_017017392.1.
UniGeneiHs.124147.

Genome annotation databases

EnsembliENST00000308783; ENSP00000309302; ENSG00000173120.
GeneIDi22992.
UCSCiuc031qbr.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000729 Genomic DNA. No translation available.
AP001885 Genomic DNA. No translation available.
JQ710742 mRNA. Translation: AFK81541.1.
RefSeqiXP_016872880.1. XM_017017391.1.
XP_016872881.1. XM_017017392.1.
UniGeneiHs.124147.

3D structure databases

ProteinModelPortaliI3VM54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000432786.

Proteomic databases

EPDiI3VM54.
PeptideAtlasiI3VM54.
PRIDEiI3VM54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308783; ENSP00000309302; ENSG00000173120.
GeneIDi22992.
UCSCiuc031qbr.2. human.

Organism-specific databases

CTDi22992.
HGNCiHGNC:13606. KDM2A.
OpenTargetsiENSG00000173120.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1633. Eukaryota.
KOG1947. Eukaryota.
ENOG410XQXU. LUCA.
GeneTreeiENSGT00550000074396.

Miscellaneous databases

ChiTaRSiKDM2A. human.
GenomeRNAii22992.

Gene expression databases

BgeeiENSG00000173120.
ExpressionAtlasiI3VM54. baseline and differential.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR003347. JmjC_dom.
IPR032675. L_dom-like.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
IPR019786. Zinc_finger_PHD-type_CS.
IPR002857. Znf_CXXC.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF02373. JmjC. 1 hit.
PF16866. PHD_4. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
SM00367. LRR_CC. 3 hits.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51184. JMJC. 1 hit.
PS51058. ZF_CXXC. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI3VM54_HUMAN
AccessioniPrimary (citable) accession number: I3VM54
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: November 30, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.