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Protein

Alanine racemase

Gene

TKWG_15575

Organism
Advenella kashmirensis (strain DSM 17095 / LMG 22695 / WT001) (Tetrathiobacter kashmirensis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway:iD-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (TKWG_15575)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei54 – 541Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei149 – 1491SubstrateUniRule annotation
Active sitei279 – 2791Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei327 – 3271Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciAKAS1036672:GL7X-2396-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:TKWG_15575Imported
OrganismiAdvenella kashmirensis (strain DSM 17095 / LMG 22695 / WT001) (Tetrathiobacter kashmirensis)Imported
Taxonomic identifieri1036672 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceae
ProteomesiUP000005267 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI3UDM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiELMAVQH.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I3UDM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRPIRAVIS QQAMSHNLSV IRQYLDNARQ APVTAADGAQ PAPMGATHIW
60 70 80 90 100
AVIKANAYGH GLETAIGGFA QADGLAMLDL QETERAREAG WQGPLLMLEG
110 120 130 140 150
FFETRDLPLL QKNRVVSTIH HPEQIRMLQA STLAGPLDVF LKINTGMNRL
160 170 180 190 200
GFAPQQFDQA HQDLLALQQQ GKVGRIGFMT HFADADGAQG AVDVPATVFR
210 220 230 240 250
DTVGQCQGSI SLCNSAAVLR YPQLAVSAAD NWVRPGICLY GSSPFANTTG
260 270 280 290 300
EEFGLRQTMT LQARLLSIQQ VKQGQSVGYG STYTATRDMR IGVVACGYAD
310 320 330 340 350
GYPRSAPSGT PAWVNGVATE LAGRVSMDML TVDLDPIPDA AVGDWVTLWG
360 370 380 390
NNGPHIDEVA AAAGTIAYEL LCALAQRVPV HVQYSGESVE K
Length:391
Mass (Da):41,868
Last modified:September 5, 2012 - v1
Checksum:i1237AE1D8C228F1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003555 Genomic DNA. Translation: AFK63108.1.
RefSeqiWP_014751199.1. NC_017964.1.

Genome annotation databases

EnsemblBacteriaiAFK63108; AFK63108; TKWG_15575.
KEGGiaka:TKWG_15575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003555 Genomic DNA. Translation: AFK63108.1.
RefSeqiWP_014751199.1. NC_017964.1.

3D structure databases

ProteinModelPortaliI3UDM0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFK63108; AFK63108; TKWG_15575.
KEGGiaka:TKWG_15575.

Phylogenomic databases

KOiK01775.
OMAiELMAVQH.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciAKAS1036672:GL7X-2396-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Whole-genome shotgun sequencing of the sulfur-oxidizing chemoautotroph Tetrathiobacter kashmirensis."
    Ghosh W., George A., Agarwal A., Raj P., Alam M., Pyne P., Das Gupta S.K.
    J. Bacteriol. 193:5553-5554(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17095 / LMG 22695 / WT001Imported.

Entry informationi

Entry nameiI3UDM0_ADVKW
AccessioniPrimary (citable) accession number: I3UDM0
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: July 22, 2015
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.