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I3UDM0

- I3UDM0_ADVKW

UniProt

I3UDM0 - I3UDM0_ADVKW

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Protein
Alanine racemase
Gene
TKWG_15575
Organism
Advenella kashmirensis (strain DSM 17095 / LMG 22695 / WT001) (Tetrathiobacter kashmirensis)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei54 – 541Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei149 – 1491Substrate By similarityUniRule annotation
Active sitei279 – 2791Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei327 – 3271Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciAKAS1036672:GL7X-2396-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:TKWG_15575Imported
OrganismiAdvenella kashmirensis (strain DSM 17095 / LMG 22695 / WT001) (Tetrathiobacter kashmirensis)Imported
Taxonomic identifieri1036672 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceae
ProteomesiUP000005267: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI3UDM0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I3UDM0-1 [UniParc]FASTAAdd to Basket

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MPRPIRAVIS QQAMSHNLSV IRQYLDNARQ APVTAADGAQ PAPMGATHIW    50
AVIKANAYGH GLETAIGGFA QADGLAMLDL QETERAREAG WQGPLLMLEG 100
FFETRDLPLL QKNRVVSTIH HPEQIRMLQA STLAGPLDVF LKINTGMNRL 150
GFAPQQFDQA HQDLLALQQQ GKVGRIGFMT HFADADGAQG AVDVPATVFR 200
DTVGQCQGSI SLCNSAAVLR YPQLAVSAAD NWVRPGICLY GSSPFANTTG 250
EEFGLRQTMT LQARLLSIQQ VKQGQSVGYG STYTATRDMR IGVVACGYAD 300
GYPRSAPSGT PAWVNGVATE LAGRVSMDML TVDLDPIPDA AVGDWVTLWG 350
NNGPHIDEVA AAAGTIAYEL LCALAQRVPV HVQYSGESVE K 391
Length:391
Mass (Da):41,868
Last modified:September 5, 2012 - v1
Checksum:i1237AE1D8C228F1D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003555 Genomic DNA. Translation: AFK63108.1.
RefSeqiWP_014751199.1. NC_017964.1.
YP_006380090.1. NC_017964.1.

Genome annotation databases

EnsemblBacteriaiAFK63108; AFK63108; TKWG_15575.
GeneIDi12997861.
KEGGiaka:TKWG_15575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003555 Genomic DNA. Translation: AFK63108.1 .
RefSeqi WP_014751199.1. NC_017964.1.
YP_006380090.1. NC_017964.1.

3D structure databases

ProteinModelPortali I3UDM0.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFK63108 ; AFK63108 ; TKWG_15575 .
GeneIDi 12997861.
KEGGi aka:TKWG_15575.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci AKAS1036672:GL7X-2396-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome shotgun sequencing of the sulfur-oxidizing chemoautotroph Tetrathiobacter kashmirensis."
    Ghosh W., George A., Agarwal A., Raj P., Alam M., Pyne P., Das Gupta S.K.
    J. Bacteriol. 193:5553-5554(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 17095 / LMG 22695 / WT001.

Entry informationi

Entry nameiI3UDM0_ADVKW
AccessioniPrimary (citable) accession number: I3UDM0
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: September 3, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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