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I3UDM0

- I3UDM0_ADVKW

UniProt

I3UDM0 - I3UDM0_ADVKW

Protein

Alanine racemase

Gene

TKWG_15575

Organism
Advenella kashmirensis (strain DSM 17095 / LMG 22695 / WT001) (Tetrathiobacter kashmirensis)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 16 (01 Oct 2014)
      Sequence version 1 (05 Sep 2012)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei54 – 541Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei149 – 1491SubstrateUniRule annotation
    Active sitei279 – 2791Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei327 – 3271Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciAKAS1036672:GL7X-2396-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:TKWG_15575Imported
    OrganismiAdvenella kashmirensis (strain DSM 17095 / LMG 22695 / WT001) (Tetrathiobacter kashmirensis)Imported
    Taxonomic identifieri1036672 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceae
    ProteomesiUP000005267: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei54 – 541N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliI3UDM0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I3UDM0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRPIRAVIS QQAMSHNLSV IRQYLDNARQ APVTAADGAQ PAPMGATHIW    50
    AVIKANAYGH GLETAIGGFA QADGLAMLDL QETERAREAG WQGPLLMLEG 100
    FFETRDLPLL QKNRVVSTIH HPEQIRMLQA STLAGPLDVF LKINTGMNRL 150
    GFAPQQFDQA HQDLLALQQQ GKVGRIGFMT HFADADGAQG AVDVPATVFR 200
    DTVGQCQGSI SLCNSAAVLR YPQLAVSAAD NWVRPGICLY GSSPFANTTG 250
    EEFGLRQTMT LQARLLSIQQ VKQGQSVGYG STYTATRDMR IGVVACGYAD 300
    GYPRSAPSGT PAWVNGVATE LAGRVSMDML TVDLDPIPDA AVGDWVTLWG 350
    NNGPHIDEVA AAAGTIAYEL LCALAQRVPV HVQYSGESVE K 391
    Length:391
    Mass (Da):41,868
    Last modified:September 5, 2012 - v1
    Checksum:i1237AE1D8C228F1D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003555 Genomic DNA. Translation: AFK63108.1.
    RefSeqiWP_014751199.1. NC_017964.1.
    YP_006380090.1. NC_017964.1.

    Genome annotation databases

    EnsemblBacteriaiAFK63108; AFK63108; TKWG_15575.
    GeneIDi12997861.
    KEGGiaka:TKWG_15575.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003555 Genomic DNA. Translation: AFK63108.1 .
    RefSeqi WP_014751199.1. NC_017964.1.
    YP_006380090.1. NC_017964.1.

    3D structure databases

    ProteinModelPortali I3UDM0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFK63108 ; AFK63108 ; TKWG_15575 .
    GeneIDi 12997861.
    KEGGi aka:TKWG_15575.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci AKAS1036672:GL7X-2396-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole-genome shotgun sequencing of the sulfur-oxidizing chemoautotroph Tetrathiobacter kashmirensis."
      Ghosh W., George A., Agarwal A., Raj P., Alam M., Pyne P., Das Gupta S.K.
      J. Bacteriol. 193:5553-5554(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 17095 / LMG 22695 / WT001Imported.

    Entry informationi

    Entry nameiI3UDM0_ADVKW
    AccessioniPrimary (citable) accession number: I3UDM0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 5, 2012
    Last sequence update: September 5, 2012
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3