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Protein

Alanine racemase

Gene

TMO_1874

Organism
Tistrella mobilis (strain KA081020-065)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei158 – 1581SubstrateUniRule annotation
Active sitei280 – 2801Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei328 – 3281Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciTMOB1110502:GLMJ-1893-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:TMO_1874Imported
OrganismiTistrella mobilis (strain KA081020-065)Imported
Taxonomic identifieri1110502 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeTistrella
ProteomesiUP000005258 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI3TLS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiNANCARL.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I3TLS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTPLTALPA APAAPPPAWI EIDLDALAEN HARLTGLMRA HNPAAEVTGV
60 70 80 90 100
IKADGYGLGA DIVGPALARA GAPALFVAHL SEGAALRRAL RADPDPARHA
110 120 130 140 150
LPVYILNGMA EGERADFLAF DLRPVLNGPD DLDRWTRAGQ AQGGPLPAAL
160 170 180 190 200
HIDTGMSRLG FDEAGFKALA ADPARLGGVD IRITMSHLAC ADDPAHPLNR
210 220 230 240 250
RQLDRFRAVT AVVGRGRLSL ANSSGLFLGP DFHFDLGRPG VALYGVNPVP
260 270 280 290 300
GHPNPMVPVV RLKARVLQVR TIDSFESVGY GAAARARPGM RVATLAIGYA
310 320 330 340 350
DGWPWSAAGK GEVVIAGHRA PILGRVSMDL VTVDVSTLPE PLIHGGAVAE
360 370 380 390 400
LIGDHRDIDA LAKDAGTIGY EILTRLGRRY ARQPMTSGQT QVYPIGVPTP

QTEVDPAP
Length:408
Mass (Da):42,856
Last modified:September 5, 2012 - v1
Checksum:iDDE662A4BEFA99E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003236 Genomic DNA. Translation: AFK53713.1.
RefSeqiWP_014745391.1. NC_017956.1.
YP_006371297.1. NC_017956.1.

Genome annotation databases

EnsemblBacteriaiAFK53713; AFK53713; TMO_1874.
KEGGitmo:TMO_1874.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003236 Genomic DNA. Translation: AFK53713.1.
RefSeqiWP_014745391.1. NC_017956.1.
YP_006371297.1. NC_017956.1.

3D structure databases

ProteinModelPortaliI3TLS5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFK53713; AFK53713; TMO_1874.
KEGGitmo:TMO_1874.

Phylogenomic databases

KOiK01775.
OMAiNANCARL.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciTMOB1110502:GLMJ-1893-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KA081020-065Imported.

Entry informationi

Entry nameiI3TLS5_TISMK
AccessioniPrimary (citable) accession number: I3TLS5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: April 1, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.