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I3TLS5

- I3TLS5_TISMK

UniProt

I3TLS5 - I3TLS5_TISMK

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Protein
Alanine racemase
Gene
TMO_1874
Organism
Tistrella mobilis (strain KA081020-065)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei158 – 1581Substrate By similarityUniRule annotation
Active sitei280 – 2801Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei328 – 3281Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciTMOB1110502:GLMJ-1893-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:TMO_1874Imported
OrganismiTistrella mobilis (strain KA081020-065)Imported
Taxonomic identifieri1110502 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeTistrella
ProteomesiUP000005258: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI3TLS5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01775.
OMAiMNLDMVR.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I3TLS5-1 [UniParc]FASTAAdd to Basket

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MSTPLTALPA APAAPPPAWI EIDLDALAEN HARLTGLMRA HNPAAEVTGV    50
IKADGYGLGA DIVGPALARA GAPALFVAHL SEGAALRRAL RADPDPARHA 100
LPVYILNGMA EGERADFLAF DLRPVLNGPD DLDRWTRAGQ AQGGPLPAAL 150
HIDTGMSRLG FDEAGFKALA ADPARLGGVD IRITMSHLAC ADDPAHPLNR 200
RQLDRFRAVT AVVGRGRLSL ANSSGLFLGP DFHFDLGRPG VALYGVNPVP 250
GHPNPMVPVV RLKARVLQVR TIDSFESVGY GAAARARPGM RVATLAIGYA 300
DGWPWSAAGK GEVVIAGHRA PILGRVSMDL VTVDVSTLPE PLIHGGAVAE 350
LIGDHRDIDA LAKDAGTIGY EILTRLGRRY ARQPMTSGQT QVYPIGVPTP 400
QTEVDPAP 408
Length:408
Mass (Da):42,856
Last modified:September 5, 2012 - v1
Checksum:iDDE662A4BEFA99E0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003236 Genomic DNA. Translation: AFK53713.1.
RefSeqiWP_014745391.1. NC_017956.1.
YP_006371297.1. NC_017956.1.

Genome annotation databases

EnsemblBacteriaiAFK53713; AFK53713; TMO_1874.
GeneIDi13004988.
KEGGitmo:TMO_1874.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003236 Genomic DNA. Translation: AFK53713.1 .
RefSeqi WP_014745391.1. NC_017956.1.
YP_006371297.1. NC_017956.1.

3D structure databases

ProteinModelPortali I3TLS5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFK53713 ; AFK53713 ; TMO_1874 .
GeneIDi 13004988.
KEGGi tmo:TMO_1874.

Phylogenomic databases

KOi K01775.
OMAi MNLDMVR.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci TMOB1110502:GLMJ-1893-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KA081020-065Imported.

Entry informationi

Entry nameiI3TLS5_TISMK
AccessioniPrimary (citable) accession number: I3TLS5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: September 3, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi