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I3TLS5

- I3TLS5_TISMK

UniProt

I3TLS5 - I3TLS5_TISMK

Protein

Alanine racemase

Gene

TMO_1874

Organism
Tistrella mobilis (strain KA081020-065)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (05 Sep 2012)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei52 – 521Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei158 – 1581SubstrateUniRule annotation
    Active sitei280 – 2801Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei328 – 3281Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciTMOB1110502:GLMJ-1893-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:TMO_1874Imported
    OrganismiTistrella mobilis (strain KA081020-065)Imported
    Taxonomic identifieri1110502 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeTistrella
    ProteomesiUP000005258: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei52 – 521N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliI3TLS5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.
    OMAiMNLDMVR.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I3TLS5-1 [UniParc]FASTAAdd to Basket

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    MSTPLTALPA APAAPPPAWI EIDLDALAEN HARLTGLMRA HNPAAEVTGV    50
    IKADGYGLGA DIVGPALARA GAPALFVAHL SEGAALRRAL RADPDPARHA 100
    LPVYILNGMA EGERADFLAF DLRPVLNGPD DLDRWTRAGQ AQGGPLPAAL 150
    HIDTGMSRLG FDEAGFKALA ADPARLGGVD IRITMSHLAC ADDPAHPLNR 200
    RQLDRFRAVT AVVGRGRLSL ANSSGLFLGP DFHFDLGRPG VALYGVNPVP 250
    GHPNPMVPVV RLKARVLQVR TIDSFESVGY GAAARARPGM RVATLAIGYA 300
    DGWPWSAAGK GEVVIAGHRA PILGRVSMDL VTVDVSTLPE PLIHGGAVAE 350
    LIGDHRDIDA LAKDAGTIGY EILTRLGRRY ARQPMTSGQT QVYPIGVPTP 400
    QTEVDPAP 408
    Length:408
    Mass (Da):42,856
    Last modified:September 5, 2012 - v1
    Checksum:iDDE662A4BEFA99E0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003236 Genomic DNA. Translation: AFK53713.1.
    RefSeqiWP_014745391.1. NC_017956.1.
    YP_006371297.1. NC_017956.1.

    Genome annotation databases

    EnsemblBacteriaiAFK53713; AFK53713; TMO_1874.
    GeneIDi13004988.
    KEGGitmo:TMO_1874.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003236 Genomic DNA. Translation: AFK53713.1 .
    RefSeqi WP_014745391.1. NC_017956.1.
    YP_006371297.1. NC_017956.1.

    3D structure databases

    ProteinModelPortali I3TLS5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFK53713 ; AFK53713 ; TMO_1874 .
    GeneIDi 13004988.
    KEGGi tmo:TMO_1874.

    Phylogenomic databases

    KOi K01775.
    OMAi MNLDMVR.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci TMOB1110502:GLMJ-1893-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KA081020-065Imported.

    Entry informationi

    Entry nameiI3TLS5_TISMK
    AccessioniPrimary (citable) accession number: I3TLS5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 5, 2012
    Last sequence update: September 5, 2012
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3