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Protein

Isocitrate dehydrogenase [NADP]

Gene

TMO_1136

Organism
Tistrella mobilis (strain KA081020-065)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871SubstrateUniRule annotation
Binding sitei92 – 921NADPUniRule annotation
Binding sitei119 – 1191SubstrateUniRule annotation
Binding sitei142 – 1421SubstrateUniRule annotation
Sitei149 – 1491Critical for catalysisUniRule annotation
Sitei221 – 2211Critical for catalysisUniRule annotation
Metal bindingi261 – 2611Magnesium or manganeseUniRule annotation
Binding sitei269 – 2691NADPUniRule annotation
Metal bindingi284 – 2841Magnesium or manganeseUniRule annotation
Binding sitei337 – 3371NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi85 – 873NADPUniRule annotation
Nucleotide bindingi319 – 3246NADPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciTMOB1110502:GLMJ-1152-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:TMO_1136Imported
OrganismiTistrella mobilis (strain KA081020-065)Imported
Taxonomic identifieri1110502 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeTistrella
ProteomesiUP000005258 Componenti: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni104 – 1107Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.
OMAiTQYNTDD.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I3TJN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRIAEEIVR MTKIKVANPV VELDGDEMTR IIWRFIKDKL ILPYLDVDLL
60 70 80 90 100
YYDLGVEHRD ATNDKVTVDA AEAIAKHGVG VKCATITPDE ARVEEFKLKQ
110 120 130 140 150
MWKSPNGTIR NILGGTVFRE PIICRNVPRL VPGWTQPIVI GRHAFGDQYR
160 170 180 190 200
ATDFKVPGKG TLTVRFQPED GGEAIEYEVF KFPGSGVAMA MYNLDESIRG
210 220 230 240 250
FARACMNYGL QRGYPVYLST KNTILKAYDG RFKDLFQEVF DAEFADQFKA
260 270 280 290 300
AGIVYEHRLI DDMVASALKW DGGFVWACKN YDGDVQSDTV AQGFGSLGLM
310 320 330 340 350
TSVLMTPDGK TVEAEAAHGT VTRHFREHQK GRETSTNPIA SIFAWTRGLG
360 370 380 390 400
YRGKFDGNDA LIGFAETLER VCVETVEAGH MTKDLAILVG KDQAWLNTNA
410
FLDKIDENLK KAMAS
Length:415
Mass (Da):46,329
Last modified:September 5, 2012 - v1
Checksum:iBA26676BD26AD356
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003236 Genomic DNA. Translation: AFK52975.1.

Genome annotation databases

EnsemblBacteriaiAFK52975; AFK52975; TMO_1136.
KEGGitmo:TMO_1136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003236 Genomic DNA. Translation: AFK52975.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFK52975; AFK52975; TMO_1136.
KEGGitmo:TMO_1136.

Phylogenomic databases

KOiK00031.
OMAiTQYNTDD.

Enzyme and pathway databases

BioCyciTMOB1110502:GLMJ-1152-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KA081020-065Imported.

Entry informationi

Entry nameiI3TJN7_TISMK
AccessioniPrimary (citable) accession number: I3TJN7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: July 22, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.