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I3TJN7

- I3TJN7_TISMK

UniProt

I3TJN7 - I3TJN7_TISMK

Protein

Isocitrate dehydrogenase [NADP]

Gene

TMO_1136

Organism
Tistrella mobilis (strain KA081020-065)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 14 (01 Oct 2014)
      Sequence version 1 (05 Sep 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei87 – 871SubstrateUniRule annotation
    Binding sitei92 – 921NADP
    Binding sitei119 – 1191SubstrateUniRule annotation
    Binding sitei142 – 1421SubstrateUniRule annotation
    Sitei149 – 1491Critical for catalysisUniRule annotation
    Sitei221 – 2211Critical for catalysisUniRule annotation
    Metal bindingi261 – 2611Magnesium or manganeseUniRule annotation
    Binding sitei269 – 2691NADP
    Metal bindingi284 – 2841Magnesium or manganeseUniRule annotation
    Binding sitei337 – 3371NADP; via amide nitrogen and carbonyl oxygen

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi85 – 873NADP
    Nucleotide bindingi319 – 3246NADP

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciTMOB1110502:GLMJ-1152-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:TMO_1136Imported
    OrganismiTistrella mobilis (strain KA081020-065)Imported
    Taxonomic identifieri1110502 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeTistrella
    ProteomesiUP000005258: Chromosome

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni104 – 1107Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.
    OMAiTRIIWDK.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I3TJN7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRIAEEIVR MTKIKVANPV VELDGDEMTR IIWRFIKDKL ILPYLDVDLL    50
    YYDLGVEHRD ATNDKVTVDA AEAIAKHGVG VKCATITPDE ARVEEFKLKQ 100
    MWKSPNGTIR NILGGTVFRE PIICRNVPRL VPGWTQPIVI GRHAFGDQYR 150
    ATDFKVPGKG TLTVRFQPED GGEAIEYEVF KFPGSGVAMA MYNLDESIRG 200
    FARACMNYGL QRGYPVYLST KNTILKAYDG RFKDLFQEVF DAEFADQFKA 250
    AGIVYEHRLI DDMVASALKW DGGFVWACKN YDGDVQSDTV AQGFGSLGLM 300
    TSVLMTPDGK TVEAEAAHGT VTRHFREHQK GRETSTNPIA SIFAWTRGLG 350
    YRGKFDGNDA LIGFAETLER VCVETVEAGH MTKDLAILVG KDQAWLNTNA 400
    FLDKIDENLK KAMAS 415
    Length:415
    Mass (Da):46,329
    Last modified:September 5, 2012 - v1
    Checksum:iBA26676BD26AD356
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003236 Genomic DNA. Translation: AFK52975.1.
    RefSeqiWP_014744654.1. NC_017956.1.
    YP_006370559.1. NC_017956.1.

    Genome annotation databases

    EnsemblBacteriaiAFK52975; AFK52975; TMO_1136.
    GeneIDi13004247.
    KEGGitmo:TMO_1136.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003236 Genomic DNA. Translation: AFK52975.1 .
    RefSeqi WP_014744654.1. NC_017956.1.
    YP_006370559.1. NC_017956.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFK52975 ; AFK52975 ; TMO_1136 .
    GeneIDi 13004247.
    KEGGi tmo:TMO_1136.

    Phylogenomic databases

    KOi K00031.
    OMAi TRIIWDK.

    Enzyme and pathway databases

    BioCyci TMOB1110502:GLMJ-1152-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KA081020-065Imported.

    Entry informationi

    Entry nameiI3TJN7_TISMK
    AccessioniPrimary (citable) accession number: I3TJN7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 5, 2012
    Last sequence update: September 5, 2012
    Last modified: October 1, 2014
    This is version 14 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3