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I3TJN7

- I3TJN7_TISMK

UniProt

I3TJN7 - I3TJN7_TISMK

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Protein

Isocitrate dehydrogenase [NADP]

Gene
TMO_1136
Organism
Tistrella mobilis (strain KA081020-065)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871Substrate By similarityUniRule annotation
Binding sitei92 – 921NADP By similarityUniRule annotation
Binding sitei119 – 1191Substrate By similarityUniRule annotation
Binding sitei142 – 1421Substrate By similarityUniRule annotation
Sitei149 – 1491Critical for catalysis By similarityUniRule annotation
Sitei221 – 2211Critical for catalysis By similarityUniRule annotation
Metal bindingi261 – 2611Magnesium or manganese By similarityUniRule annotation
Binding sitei269 – 2691NADP By similarityUniRule annotation
Metal bindingi284 – 2841Magnesium or manganese By similarityUniRule annotation
Binding sitei337 – 3371NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi85 – 873NADP By similarityUniRule annotation
Nucleotide bindingi319 – 3246NADP By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciTMOB1110502:GLMJ-1152-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:TMO_1136Imported
OrganismiTistrella mobilis (strain KA081020-065)Imported
Taxonomic identifieri1110502 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeTistrella
ProteomesiUP000005258: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni104 – 1107Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00031.
OMAiTRIIWDK.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I3TJN7-1 [UniParc]FASTAAdd to Basket

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MPRIAEEIVR MTKIKVANPV VELDGDEMTR IIWRFIKDKL ILPYLDVDLL    50
YYDLGVEHRD ATNDKVTVDA AEAIAKHGVG VKCATITPDE ARVEEFKLKQ 100
MWKSPNGTIR NILGGTVFRE PIICRNVPRL VPGWTQPIVI GRHAFGDQYR 150
ATDFKVPGKG TLTVRFQPED GGEAIEYEVF KFPGSGVAMA MYNLDESIRG 200
FARACMNYGL QRGYPVYLST KNTILKAYDG RFKDLFQEVF DAEFADQFKA 250
AGIVYEHRLI DDMVASALKW DGGFVWACKN YDGDVQSDTV AQGFGSLGLM 300
TSVLMTPDGK TVEAEAAHGT VTRHFREHQK GRETSTNPIA SIFAWTRGLG 350
YRGKFDGNDA LIGFAETLER VCVETVEAGH MTKDLAILVG KDQAWLNTNA 400
FLDKIDENLK KAMAS 415
Length:415
Mass (Da):46,329
Last modified:September 5, 2012 - v1
Checksum:iBA26676BD26AD356
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003236 Genomic DNA. Translation: AFK52975.1.
RefSeqiWP_014744654.1. NC_017956.1.
YP_006370559.1. NC_017956.1.

Genome annotation databases

EnsemblBacteriaiAFK52975; AFK52975; TMO_1136.
GeneIDi13004247.
KEGGitmo:TMO_1136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003236 Genomic DNA. Translation: AFK52975.1 .
RefSeqi WP_014744654.1. NC_017956.1.
YP_006370559.1. NC_017956.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFK52975 ; AFK52975 ; TMO_1136 .
GeneIDi 13004247.
KEGGi tmo:TMO_1136.

Phylogenomic databases

KOi K00031.
OMAi TRIIWDK.

Enzyme and pathway databases

BioCyci TMOB1110502:GLMJ-1152-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KA081020-065Imported.

Entry informationi

Entry nameiI3TJN7_TISMK
AccessioniPrimary (citable) accession number: I3TJN7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: September 3, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi