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I3TJN7

- I3TJN7_TISMK

UniProt

I3TJN7 - I3TJN7_TISMK

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Protein

Isocitrate dehydrogenase [NADP]

Gene

TMO_1136

Organism
Tistrella mobilis (strain KA081020-065)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871SubstrateUniRule annotation
Binding sitei119 – 1191SubstrateUniRule annotation
Binding sitei142 – 1421SubstrateUniRule annotation
Sitei149 – 1491Critical for catalysisUniRule annotation
Sitei221 – 2211Critical for catalysisUniRule annotation
Metal bindingi261 – 2611Magnesium or manganeseUniRule annotation
Metal bindingi284 – 2841Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciTMOB1110502:GLMJ-1152-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:TMO_1136Imported
OrganismiTistrella mobilis (strain KA081020-065)Imported
Taxonomic identifieri1110502 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeTistrella
ProteomesiUP000005258: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni104 – 1107Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.
OMAiTRIIWDK.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I3TJN7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRIAEEIVR MTKIKVANPV VELDGDEMTR IIWRFIKDKL ILPYLDVDLL
60 70 80 90 100
YYDLGVEHRD ATNDKVTVDA AEAIAKHGVG VKCATITPDE ARVEEFKLKQ
110 120 130 140 150
MWKSPNGTIR NILGGTVFRE PIICRNVPRL VPGWTQPIVI GRHAFGDQYR
160 170 180 190 200
ATDFKVPGKG TLTVRFQPED GGEAIEYEVF KFPGSGVAMA MYNLDESIRG
210 220 230 240 250
FARACMNYGL QRGYPVYLST KNTILKAYDG RFKDLFQEVF DAEFADQFKA
260 270 280 290 300
AGIVYEHRLI DDMVASALKW DGGFVWACKN YDGDVQSDTV AQGFGSLGLM
310 320 330 340 350
TSVLMTPDGK TVEAEAAHGT VTRHFREHQK GRETSTNPIA SIFAWTRGLG
360 370 380 390 400
YRGKFDGNDA LIGFAETLER VCVETVEAGH MTKDLAILVG KDQAWLNTNA
410
FLDKIDENLK KAMAS
Length:415
Mass (Da):46,329
Last modified:September 5, 2012 - v1
Checksum:iBA26676BD26AD356
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003236 Genomic DNA. Translation: AFK52975.1.
RefSeqiYP_006370559.1. NC_017956.1.

Genome annotation databases

EnsemblBacteriaiAFK52975; AFK52975; TMO_1136.
GeneIDi13004247.
KEGGitmo:TMO_1136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003236 Genomic DNA. Translation: AFK52975.1 .
RefSeqi YP_006370559.1. NC_017956.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFK52975 ; AFK52975 ; TMO_1136 .
GeneIDi 13004247.
KEGGi tmo:TMO_1136.

Phylogenomic databases

KOi K00031.
OMAi TRIIWDK.

Enzyme and pathway databases

BioCyci TMOB1110502:GLMJ-1152-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KA081020-065Imported.

Entry informationi

Entry nameiI3TJN7_TISMK
AccessioniPrimary (citable) accession number: I3TJN7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: November 26, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3