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I3TDF0

- I3TDF0_THEC1

UniProt

I3TDF0 - I3TDF0_THEC1

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Protein
Ribulose bisphosphate carboxylase
Gene
rbcL, TCELL_0363
Organism
Thermogladius cellulolyticus (strain 1633)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase By similarity.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei163 – 1631Proton acceptor By similarityUniRule annotation
Binding sitei165 – 1651Substrate By similarityUniRule annotation
Metal bindingi189 – 1891Magnesium; via carbamate group By similarityUniRule annotation
Metal bindingi191 – 1911Magnesium By similarityUniRule annotation
Metal bindingi192 – 1921Magnesium By similarityUniRule annotation
Active sitei281 – 2811Proton acceptor By similarityUniRule annotation
Binding sitei282 – 2821Substrate By similarityUniRule annotation
Binding sitei314 – 3141Substrate By similarityUniRule annotation
Sitei322 – 3221Transition state stabilizer By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. oxidoreductase activity Source: UniProtKB-KW
  3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. carbon fixation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciTCEL1184251:GLMC-383-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotation
Ordered Locus Names:TCELL_0363Imported
OrganismiThermogladius cellulolyticus (strain 1633)Imported
Taxonomic identifieri1184251 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeThermogladius
ProteomesiUP000005270: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei189 – 1891N6-carboxylysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliI3TDF0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni367 – 3693Substrate binding By similarityUniRule annotation
Regioni389 – 3924Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK01601.
OMAiVIVTFRV.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01133. RuBisCO_L_type3.
InterProiIPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

Sequencei

Sequence statusi: Complete.

I3TDF0-1 [UniParc]FASTAAdd to Basket

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MTKEGFEPYP EYVDKKYQPD PDTHVIVTFR VKPASGFTVE DAAGGVAAES    50
STGTWTTLFS WYDVSRVKKL SGRAYYFKDL KDGSYIVRVA YPVELFEEGN 100
MPAFLASVAG NIFGMRRVEG LRVEDIYLPK QFLQYFKGPF KGVKGVREIF 150
KVHDRPIVGT VPKPKVGYTP EEVEKLALEL LMGGMDYIKD DENLASPSFC 200
RFEARAKSIM KIIDKVEKET GERKAWFANI TADVREMEKR LKLVADYGNP 250
YIMVDVVVTG WSALTYIRDL AEEYKLAIHA HRAMHAAITR NPYHGISMFA 300
LAKLYRFIGM DQLHIGTAGA GKLEGAKLDV VRIAKMLRAE DYQPDPDDDF 350
HLPQKMYHIK PMMPVSSGGL HPGNLPIVIE ALGTDLVLQI GGGTIGHPDG 400
PRAGATAVRQ ALDAIIKGIP LEEYAKDHKE LARALEKWGF AKPI 444
Length:444
Mass (Da):49,590
Last modified:September 5, 2012 - v1
Checksum:i9CCE1238EE66CCA6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003531 Genomic DNA. Translation: AFK50788.1.
RefSeqiYP_006362926.1. NC_017954.1.

Genome annotation databases

EnsemblBacteriaiAFK50788; AFK50788; TCELL_0363.
GeneIDi13012650.
KEGGithg:TCELL_0363.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003531 Genomic DNA. Translation: AFK50788.1 .
RefSeqi YP_006362926.1. NC_017954.1.

3D structure databases

ProteinModelPortali I3TDF0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFK50788 ; AFK50788 ; TCELL_0363 .
GeneIDi 13012650.
KEGGi thg:TCELL_0363.

Phylogenomic databases

KOi K01601.
OMAi VIVTFRV.

Enzyme and pathway databases

BioCyci TCEL1184251:GLMC-383-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPi MF_01133. RuBisCO_L_type3.
InterProi IPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of the Hyperthermophilic Cellulolytic Crenarchaeon "Thermogladius cellulolyticus" 1633."
    Mardanov A.V., Kochetkova T.V., Beletsky A.V., Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.
    J. Bacteriol. 194:4446-4447(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1633Imported.

Entry informationi

Entry nameiI3TDF0_THEC1
AccessioniPrimary (citable) accession number: I3TDF0
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: September 3, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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