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I3TCD9

- I3TCD9_THEC1

UniProt

I3TCD9 - I3TCD9_THEC1

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Protein

DNA ligase

Gene
lig, TCELL_0002
Organism
Thermogladius cellulolyticus (strain 1633)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei257 – 2571ATP By similarityUniRule annotation
Active sitei259 – 2591N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei264 – 2641ATP By similarityUniRule annotation
Binding sitei279 – 2791ATP By similarityUniRule annotation
Binding sitei309 – 3091ATP By similarityUniRule annotation
Binding sitei349 – 3491ATP By similarityUniRule annotation
Binding sitei426 – 4261ATP By similarityUniRule annotation
Binding sitei432 – 4321ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTCEL1184251:GLMC-2-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:TCELL_0002Imported
OrganismiThermogladius cellulolyticus (strain 1633)Imported
Taxonomic identifieri1184251 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeThermogladius
ProteomesiUP000005270: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiCTDIGEL.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I3TCD9-1 [UniParc]FASTAAdd to Basket

« Hide

MLADTFESLE SITARTQMVN ILVALLKKTP AEIIDRVVYI IEERLWPDWK    50
GLPELGVAEK SIIRAIAVAT GQSDDVVERT AKTLGDLGKA AESLISTVRE 100
KQKRTTSLLS FVTSRRELTV SRVYDTFVRI AMAQGEGSKD IKIRLLSGLL 150
AEASPKEARY IVRFAEGKLR LGVGEATLMD ALAVAFGGGS FARPIIERAY 200
NLRADLGEVA RVVATKGIEE LKALKPVVGI PIRPMLAERH NNPKEILEKV 250
GGVGFVEYKY DGERAQIHKK GDEVVIFSRR LENITHQYPD VVDYVKRGVK 300
AEEAIVEGEI VAIDPDTGEF KPFQELMHRK RKHDVMSVVK EIPVRVYLFD 350
LLYLNGVDYT VKPLPERRKA LEEVIEKNEG LDIAEYITAK NPVELEKFFM 400
GAISDGAEGV MVKAIHKDSI YQAGTRGWLW IKFKRDYRSE MIDTVDLVVV 450
GAFYGRGRRG GKFGALLMAA YNEEKDVFET VCKVGSGFTD EDLNQLPDLL 500
KPYIVDKKPA RVVSNIQPDV WVVPKLVAEI IGAELTLSPL HTCAVGKVRG 550
DAGISIRFPR FIRWRDDKSP EDATTSNELF EMYKNQLKKI AEKPGEGEAT 600
Length:600
Mass (Da):67,052
Last modified:September 5, 2012 - v1
Checksum:iAE608C6118CADAF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003531 Genomic DNA. Translation: AFK50427.1.
RefSeqiYP_006362565.1. NC_017954.1.

Genome annotation databases

EnsemblBacteriaiAFK50427; AFK50427; TCELL_0002.
GeneIDi13012922.
KEGGithg:TCELL_0002.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003531 Genomic DNA. Translation: AFK50427.1 .
RefSeqi YP_006362565.1. NC_017954.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFK50427 ; AFK50427 ; TCELL_0002 .
GeneIDi 13012922.
KEGGi thg:TCELL_0002.

Phylogenomic databases

KOi K10747.
OMAi CTDIGEL.

Enzyme and pathway databases

BioCyci TCEL1184251:GLMC-2-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of the Hyperthermophilic Cellulolytic Crenarchaeon "Thermogladius cellulolyticus" 1633."
    Mardanov A.V., Kochetkova T.V., Beletsky A.V., Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.
    J. Bacteriol. 194:4446-4447(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1633Imported.

Entry informationi

Entry nameiI3TCD9_THEC1
AccessioniPrimary (citable) accession number: I3TCD9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: June 11, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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