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I3TCD9 (I3TCD9_THEC1) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase RuleBase RU000617 HAMAP-Rule MF_00407

EC=6.5.1.1 RuleBase RU000617 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig HAMAP-Rule MF_00407
Ordered Locus Names:TCELL_0002 EMBL AFK50427.1
OrganismThermogladius cellulolyticus (strain 1633) [Complete proteome] [HAMAP] EMBL AFK50427.1
Taxonomic identifier1184251 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeThermogladius

Protein attributes

Sequence length600 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617 HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2591N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2571ATP By similarity HAMAP-Rule MF_00407
Binding site2641ATP By similarity HAMAP-Rule MF_00407
Binding site2791ATP By similarity HAMAP-Rule MF_00407
Binding site3091ATP By similarity HAMAP-Rule MF_00407
Binding site3491ATP By similarity HAMAP-Rule MF_00407
Binding site4261ATP By similarity HAMAP-Rule MF_00407
Binding site4321ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
I3TCD9 [UniParc].

Last modified September 5, 2012. Version 1.
Checksum: AE608C6118CADAF6

FASTA60067,052
        10         20         30         40         50         60 
MLADTFESLE SITARTQMVN ILVALLKKTP AEIIDRVVYI IEERLWPDWK GLPELGVAEK 

        70         80         90        100        110        120 
SIIRAIAVAT GQSDDVVERT AKTLGDLGKA AESLISTVRE KQKRTTSLLS FVTSRRELTV 

       130        140        150        160        170        180 
SRVYDTFVRI AMAQGEGSKD IKIRLLSGLL AEASPKEARY IVRFAEGKLR LGVGEATLMD 

       190        200        210        220        230        240 
ALAVAFGGGS FARPIIERAY NLRADLGEVA RVVATKGIEE LKALKPVVGI PIRPMLAERH 

       250        260        270        280        290        300 
NNPKEILEKV GGVGFVEYKY DGERAQIHKK GDEVVIFSRR LENITHQYPD VVDYVKRGVK 

       310        320        330        340        350        360 
AEEAIVEGEI VAIDPDTGEF KPFQELMHRK RKHDVMSVVK EIPVRVYLFD LLYLNGVDYT 

       370        380        390        400        410        420 
VKPLPERRKA LEEVIEKNEG LDIAEYITAK NPVELEKFFM GAISDGAEGV MVKAIHKDSI 

       430        440        450        460        470        480 
YQAGTRGWLW IKFKRDYRSE MIDTVDLVVV GAFYGRGRRG GKFGALLMAA YNEEKDVFET 

       490        500        510        520        530        540 
VCKVGSGFTD EDLNQLPDLL KPYIVDKKPA RVVSNIQPDV WVVPKLVAEI IGAELTLSPL 

       550        560        570        580        590        600 
HTCAVGKVRG DAGISIRFPR FIRWRDDKSP EDATTSNELF EMYKNQLKKI AEKPGEGEAT 

« Hide

References

[1]"Complete Genome Sequence of the Hyperthermophilic Cellulolytic Crenarchaeon "Thermogladius cellulolyticus" 1633."
Mardanov A.V., Kochetkova T.V., Beletsky A.V., Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.
J. Bacteriol. 194:4446-4447(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1633 EMBL AFK50427.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003531 Genomic DNA. Translation: AFK50427.1.
RefSeqYP_006362565.1. NC_017954.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFK50427; AFK50427; TCELL_0002.
GeneID13012922.
KEGGthg:TCELL_0002.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK10747.
OMACTDIGEL.

Enzyme and pathway databases

BioCycTCEL1184251:GLMC-2-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameI3TCD9_THEC1
AccessionPrimary (citable) accession number: I3TCD9
Entry history
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: June 11, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)