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I3TCD9

- I3TCD9_THEC1

UniProt

I3TCD9 - I3TCD9_THEC1

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Protein

DNA ligase

Gene

lig

Organism
Thermogladius cellulolyticus (strain 1633)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei257 – 2571ATPUniRule annotation
Active sitei259 – 2591N6-AMP-lysine intermediateUniRule annotation
Binding sitei264 – 2641ATPUniRule annotation
Binding sitei279 – 2791ATPUniRule annotation
Binding sitei309 – 3091ATPUniRule annotation
Binding sitei349 – 3491ATPUniRule annotation
Binding sitei426 – 4261ATPUniRule annotation
Binding sitei432 – 4321ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTCEL1184251:GLMC-2-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:TCELL_0002Imported
OrganismiThermogladius cellulolyticus (strain 1633)Imported
Taxonomic identifieri1184251 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeThermogladius
ProteomesiUP000005270: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiCTDIGEL.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

I3TCD9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLADTFESLE SITARTQMVN ILVALLKKTP AEIIDRVVYI IEERLWPDWK
60 70 80 90 100
GLPELGVAEK SIIRAIAVAT GQSDDVVERT AKTLGDLGKA AESLISTVRE
110 120 130 140 150
KQKRTTSLLS FVTSRRELTV SRVYDTFVRI AMAQGEGSKD IKIRLLSGLL
160 170 180 190 200
AEASPKEARY IVRFAEGKLR LGVGEATLMD ALAVAFGGGS FARPIIERAY
210 220 230 240 250
NLRADLGEVA RVVATKGIEE LKALKPVVGI PIRPMLAERH NNPKEILEKV
260 270 280 290 300
GGVGFVEYKY DGERAQIHKK GDEVVIFSRR LENITHQYPD VVDYVKRGVK
310 320 330 340 350
AEEAIVEGEI VAIDPDTGEF KPFQELMHRK RKHDVMSVVK EIPVRVYLFD
360 370 380 390 400
LLYLNGVDYT VKPLPERRKA LEEVIEKNEG LDIAEYITAK NPVELEKFFM
410 420 430 440 450
GAISDGAEGV MVKAIHKDSI YQAGTRGWLW IKFKRDYRSE MIDTVDLVVV
460 470 480 490 500
GAFYGRGRRG GKFGALLMAA YNEEKDVFET VCKVGSGFTD EDLNQLPDLL
510 520 530 540 550
KPYIVDKKPA RVVSNIQPDV WVVPKLVAEI IGAELTLSPL HTCAVGKVRG
560 570 580 590 600
DAGISIRFPR FIRWRDDKSP EDATTSNELF EMYKNQLKKI AEKPGEGEAT
Length:600
Mass (Da):67,052
Last modified:September 5, 2012 - v1
Checksum:iAE608C6118CADAF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003531 Genomic DNA. Translation: AFK50427.1.
RefSeqiYP_006362565.1. NC_017954.1.

Genome annotation databases

EnsemblBacteriaiAFK50427; AFK50427; TCELL_0002.
GeneIDi13012922.
KEGGithg:TCELL_0002.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003531 Genomic DNA. Translation: AFK50427.1 .
RefSeqi YP_006362565.1. NC_017954.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFK50427 ; AFK50427 ; TCELL_0002 .
GeneIDi 13012922.
KEGGi thg:TCELL_0002.

Phylogenomic databases

KOi K10747.
OMAi CTDIGEL.

Enzyme and pathway databases

BioCyci TCEL1184251:GLMC-2-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the hyperthermophilic cellulolytic Crenarchaeon 'Thermogladius cellulolyticus' 1633."
    Mardanov A.V., Kochetkova T.V., Beletsky A.V., Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.
    J. Bacteriol. 194:4446-4447(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1633Imported.

Entry informationi

Entry nameiI3TCD9_THEC1
AccessioniPrimary (citable) accession number: I3TCD9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: October 29, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3