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I3TCD9

- I3TCD9_THEC1

UniProt

I3TCD9 - I3TCD9_THEC1

Protein

DNA ligase

Gene

lig

Organism
Thermogladius cellulolyticus (strain 1633)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (05 Sep 2012)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei257 – 2571ATPUniRule annotation
    Active sitei259 – 2591N6-AMP-lysine intermediateUniRule annotation
    Binding sitei264 – 2641ATPUniRule annotation
    Binding sitei279 – 2791ATPUniRule annotation
    Binding sitei309 – 3091ATPUniRule annotation
    Binding sitei349 – 3491ATPUniRule annotation
    Binding sitei426 – 4261ATPUniRule annotation
    Binding sitei432 – 4321ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTCEL1184251:GLMC-2-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:TCELL_0002Imported
    OrganismiThermogladius cellulolyticus (strain 1633)Imported
    Taxonomic identifieri1184251 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeThermogladius
    ProteomesiUP000005270: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.
    OMAiCTDIGEL.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I3TCD9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLADTFESLE SITARTQMVN ILVALLKKTP AEIIDRVVYI IEERLWPDWK    50
    GLPELGVAEK SIIRAIAVAT GQSDDVVERT AKTLGDLGKA AESLISTVRE 100
    KQKRTTSLLS FVTSRRELTV SRVYDTFVRI AMAQGEGSKD IKIRLLSGLL 150
    AEASPKEARY IVRFAEGKLR LGVGEATLMD ALAVAFGGGS FARPIIERAY 200
    NLRADLGEVA RVVATKGIEE LKALKPVVGI PIRPMLAERH NNPKEILEKV 250
    GGVGFVEYKY DGERAQIHKK GDEVVIFSRR LENITHQYPD VVDYVKRGVK 300
    AEEAIVEGEI VAIDPDTGEF KPFQELMHRK RKHDVMSVVK EIPVRVYLFD 350
    LLYLNGVDYT VKPLPERRKA LEEVIEKNEG LDIAEYITAK NPVELEKFFM 400
    GAISDGAEGV MVKAIHKDSI YQAGTRGWLW IKFKRDYRSE MIDTVDLVVV 450
    GAFYGRGRRG GKFGALLMAA YNEEKDVFET VCKVGSGFTD EDLNQLPDLL 500
    KPYIVDKKPA RVVSNIQPDV WVVPKLVAEI IGAELTLSPL HTCAVGKVRG 550
    DAGISIRFPR FIRWRDDKSP EDATTSNELF EMYKNQLKKI AEKPGEGEAT 600
    Length:600
    Mass (Da):67,052
    Last modified:September 5, 2012 - v1
    Checksum:iAE608C6118CADAF6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003531 Genomic DNA. Translation: AFK50427.1.
    RefSeqiYP_006362565.1. NC_017954.1.

    Genome annotation databases

    EnsemblBacteriaiAFK50427; AFK50427; TCELL_0002.
    GeneIDi13012922.
    KEGGithg:TCELL_0002.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003531 Genomic DNA. Translation: AFK50427.1 .
    RefSeqi YP_006362565.1. NC_017954.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFK50427 ; AFK50427 ; TCELL_0002 .
    GeneIDi 13012922.
    KEGGi thg:TCELL_0002.

    Phylogenomic databases

    KOi K10747.
    OMAi CTDIGEL.

    Enzyme and pathway databases

    BioCyci TCEL1184251:GLMC-2-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the hyperthermophilic cellulolytic Crenarchaeon 'Thermogladius cellulolyticus' 1633."
      Mardanov A.V., Kochetkova T.V., Beletsky A.V., Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.
      J. Bacteriol. 194:4446-4447(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1633Imported.

    Entry informationi

    Entry nameiI3TCD9_THEC1
    AccessioniPrimary (citable) accession number: I3TCD9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 5, 2012
    Last sequence update: September 5, 2012
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3