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I3RFS7

- I3RFS7_9EURY

UniProt

I3RFS7 - I3RFS7_9EURY

Protein

DNA ligase

Gene

lig

Organism
Pyrococcus sp. ST04
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (05 Sep 2012)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei247 – 2471ATPUniRule annotation
    Active sitei249 – 2491N6-AMP-lysine intermediateUniRule annotation
    Binding sitei254 – 2541ATPUniRule annotation
    Binding sitei269 – 2691ATPUniRule annotation
    Binding sitei299 – 2991ATPUniRule annotation
    Binding sitei339 – 3391ATPUniRule annotation
    Binding sitei414 – 4141ATPUniRule annotation
    Binding sitei420 – 4201ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPSP1183377:GLJ2-1559-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    ORF Names:Py04_1516Imported
    OrganismiPyrococcus sp. ST04Imported
    Taxonomic identifieri1183377 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000006467: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    I3RFS7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRYLELAQLY QKLEKTTMKL IKTRLVADFL KKVPDDHLEF IPYLILGDVF    50
    PEWDERELGV GEKLLIKAVA MATGIDANEI ENSVKDTGDL GESIALAVKK 100
    RKQKSFFSQP LTIKRVYQTL VKVAETTGEG SQEKKMKYLA NLFMDAEPIE 150
    AKYIARTVLG TMRTGVAEGL LRDAIALAFH VKVELVERAY MLTSDFGFVA 200
    KVAKLEGNEG LAKVQVQIGK PIKPMLAQQA ANIKEALLEM GGEAEFEIKY 250
    DGARVQVHKD GDKIIVYSRR LENVTRAIPE IVEALKQSVK PNKAIVEGEL 300
    VAIGEDGRPL PFQYVLRRFR RKHNIQEMMK KIPLELNLFD VLYVDGESMI 350
    DVKFIDRRKK LEEIIEPNGK IKVAENLITK KVEEAEAFYK KALEMGHEGL 400
    MAKRLDATYE PGNRGKKWLK IKPTMENLDL VIIGAEWGEG RRAHLLGSFI 450
    LGAYDPETGE FLEVGKVGSG FTDEDLVEFT KMLKPLIIKE EGKRVWIEPK 500
    IVIEVTYQEI QKSPKYKSGF ALRFPRYVAL RDDKGPEDAD TIERIAQLYE 550
    LQERMKGKV 559
    Length:559
    Mass (Da):63,465
    Last modified:September 5, 2012 - v1
    Checksum:i40405D1D414E2625
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003534 Genomic DNA. Translation: AFK23087.1.
    RefSeqiWP_014734609.1. NC_017946.1.
    YP_006355162.1. NC_017946.1.

    Genome annotation databases

    EnsemblBacteriaiAFK23087; AFK23087; Py04_1516.
    GeneIDi13022782.
    KEGGipys:Py04_1516.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003534 Genomic DNA. Translation: AFK23087.1 .
    RefSeqi WP_014734609.1. NC_017946.1.
    YP_006355162.1. NC_017946.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFK23087 ; AFK23087 ; Py04_1516 .
    GeneIDi 13022782.
    KEGGi pys:Py04_1516.

    Phylogenomic databases

    KOi K10747.

    Enzyme and pathway databases

    BioCyci PSP1183377:GLJ2-1559-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete Genome Sequence of the Hyperthermophilic Archaeon Pyrococcus sp. Strain ST04, Isolated from a Deep-Sea Hydrothermal Sulfide Chimney on the Juan de Fuca Ridge."
      Jung J.H., Lee J.H., Holden J.F., Seo D.H., Shin H., Kim H.Y., Kim W., Ryu S., Park C.S.
      J. Bacteriol. 194:4434-4435(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ST04Imported.

    Entry informationi

    Entry nameiI3RFS7_9EURY
    AccessioniPrimary (citable) accession number: I3RFS7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 5, 2012
    Last sequence update: September 5, 2012
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3