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Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Pyrococcus sp. ST04
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciPSP1183377:GLJ2-77-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcAUniRule annotation
ORF Names:Py04_0074Imported
OrganismiPyrococcus sp. ST04Imported
Taxonomic identifieri1183377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000006467: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.UniRule annotation

Phylogenomic databases

KOiK01595.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

I3RBS0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTQHPDNYS IPFFSHSPVL GGEDEITEAF YAYSVLGADE QMWDFEGKEV
60 70 80 90 100
DEFVVKKLLE RYPMFFKKKI LGKDLRLTPR VPNPSVEKAE AKLLLETLQG
110 120 130 140 150
ITRAADYARI FYNDSIAPIF EVILPMTTSS AELERVYQLY KKIVGISSEV
160 170 180 190 200
IHDVTVGEWI GEFYPEEIRI IPLFETKSAL LKSSRIVKEF LKDKDFEHQR
210 220 230 240 250
VFFARSDPAM NYGLITAVTY VKKALYELAK LEEEMSISLY PIVGVGGPPF
260 270 280 290 300
RGGMRPDNVD VVLEEYPSVQ TYTIQSSFKF DYPARDVVKA VDKIKSTKRR
310 320 330 340 350
APTPVDIPEF LTAYEVEYQN QIKLLAPHIR RLASRIPDRR RRKLHIGLFG
360 370 380 390 400
YARNVNGLAL PRAIKFTASL YSIGLPPELL ALNSVTDKDL ERVSEYYLHV
410 420 430 440 450
YDDLEFAMKF FSFKVAEEVG LKKLAERVRE FKPDQIQEYV EEAELVFRGE
460
GDVMKLAQMR GFLG
Length:464
Mass (Da):53,287
Last modified:September 5, 2012 - v1
Checksum:i7DD6E0511441E7F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003534 Genomic DNA. Translation: AFK21680.1.
RefSeqiWP_014733206.1. NC_017946.1.
YP_006353755.1. NC_017946.1.

Genome annotation databases

EnsemblBacteriaiAFK21680; AFK21680; Py04_0074.
GeneIDi13021297.
KEGGipys:Py04_0074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003534 Genomic DNA. Translation: AFK21680.1.
RefSeqiWP_014733206.1. NC_017946.1.
YP_006353755.1. NC_017946.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFK21680; AFK21680; Py04_0074.
GeneIDi13021297.
KEGGipys:Py04_0074.

Phylogenomic databases

KOiK01595.

Enzyme and pathway databases

BioCyciPSP1183377:GLJ2-77-MONOMER.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete Genome Sequence of the Hyperthermophilic Archaeon Pyrococcus sp. Strain ST04, Isolated from a Deep-Sea Hydrothermal Sulfide Chimney on the Juan de Fuca Ridge."
    Jung J.H., Lee J.H., Holden J.F., Seo D.H., Shin H., Kim H.Y., Kim W., Ryu S., Park C.S.
    J. Bacteriol. 194:4434-4435(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ST04Imported.

Entry informationi

Entry nameiI3RBS0_9EURY
AccessioniPrimary (citable) accession number: I3RBS0
Entry historyi
Integrated into UniProtKB/TrEMBL: September 5, 2012
Last sequence update: September 5, 2012
Last modified: January 7, 2015
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.