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Protein

Bcl-2-like protein 11

Gene

BCL2L11

Organism
Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Induces apoptosis and anoikis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 11UniRule annotation
Short name:
Bcl2-L-11UniRule annotation
Alternative name(s):
Bcl2-interacting mediator of cell deathUniRule annotation
Gene namesi
Name:BCL2L11Imported
OrganismiIctidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)Imported
Taxonomic identifieri43179 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciuromorphaSciuridaeXerinaeMarmotiniIctidomys
Proteomesi
  • UP000005215 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation, MitochondrionUniRule annotation

Interactioni

Subunit structurei

Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi43179.ENSSTOP00000023052

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 40Bim_NInterPro annotationAdd BLAST37
Domaini128 – 164Bclx_interactInterPro annotationAdd BLAST37

Sequence similaritiesi

Belongs to the Bcl-2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IZKS Eukaryota
ENOG410Y8GB LUCA
GeneTreeiENSGT00390000003178
InParanoidiI3NFA5
OMAiAEDHPQM
OrthoDBiEOG091G0XD3
TreeFamiTF335898

Family and domain databases

InterProiView protein in InterPro
IPR014771 Apoptosis_Bim_N
IPR017288 Bcl-2-like_11
IPR015040 Bcl-x_interacting_BH3_dom
PfamiView protein in Pfam
PF08945 Bclx_interact, 1 hit
PF06773 Bim_N, 1 hit
PIRSFiPIRSF037827 Bcl-2-like_p11, 1 hit

Sequencei

Sequence statusi: Complete.

I3NFA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKQPSDVSS ECDREGGQLQ PAERPPQLRP GAPTSLQTEP QGNPEGEGDR
60 70 80 90 100
CPHGSPQGPL APPASPGPFA TRSPLFIFVR RSSLLSRSSS GYFSFDTDRS
110 120 130 140 150
PAPMSCDKST QTPSPPCQAF NHYLSAMASM RESQAEPADM RPEIWIAQEL
160 170 180 190
RRIGDEFNLY YPRRVFFNNY QPEDRPQMVI LRLLRCIIRL VWRMH
Length:195
Mass (Da):21,962
Last modified:July 11, 2012 - v1
Checksum:i2E17B941EFCAA042
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGTP01106812 Genomic DNA No translation available.
AGTP01106813 Genomic DNA No translation available.
RefSeqiXP_013220629.1, XM_013365175.1

Genome annotation databases

EnsembliENSSTOT00000028135; ENSSTOP00000023052; ENSSTOG00000027005
GeneIDi101957870

Similar proteinsi

Entry informationi

Entry nameiI3NFA5_ICTTR
AccessioniPrimary (citable) accession number: I3NFA5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: March 28, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health