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Protein

Aminopeptidase

Gene

ERAP1

Organism
Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminopeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Protein family/group databases

MEROPSiM01.018

Names & Taxonomyi

Protein namesi
Recommended name:
AminopeptidaseUniRule annotation (EC:3.4.11.-UniRule annotation)
Gene namesi
Name:ERAP1Imported
OrganismiIctidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)Imported
Taxonomic identifieri43179 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciuromorphaSciuridaeXerinaeMarmotiniIctidomys
Proteomesi
  • UP000005215 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500367706030 – 938AminopeptidaseSequence analysisAdd BLAST909

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi43179.ENSSTOP00000013687

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini263 – 523Peptidase_M1InterPro annotationAdd BLAST261
Domaini594 – 913ERAP1_CInterPro annotationAdd BLAST320

Sequence similaritiesi

Belongs to the peptidase M1 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1046 Eukaryota
COG0308 LUCA
GeneTreeiENSGT00760000119082
InParanoidiI3MPH1
OMAiDTGYLWH
OrthoDBiEOG091G01GH
TreeFamiTF300395

Family and domain databases

CDDicd09601 M1_APN_2, 1 hit
InterProiView protein in InterPro
IPR033520 ERAP1
IPR024571 ERAP1-like_C_dom
IPR034016 M1_APN-typ
IPR001930 Peptidase_M1
IPR014782 Peptidase_M1_N
PANTHERiPTHR11533 PTHR11533, 1 hit
PTHR11533:SF156 PTHR11533:SF156, 1 hit
PfamiView protein in Pfam
PF11838 ERAP1_C, 1 hit
PF01433 Peptidase_M1, 1 hit
PRINTSiPR00756 ALADIPTASE

Sequencei

Sequence statusi: Complete.

I3MPH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSLPLPWPL ISKLFLLSSL LTLTTPSWCQ NSDATSPKAS DGMPFPWNKM
60 70 80 90 100
RLPEHVIPVH YDLMIHANLS TLTFSGSTEI EITASQPTST IILHSHRLQI
110 120 130 140 150
SKATLRKGAA SERASEELLR VLEYPPHEQI ALLAPEPLLT GLPYTVTIDF
160 170 180 190 200
AGNLSESFHG FYKSTYRTKE GEVRVLASTQ FEPTAARMAF PCFDEPALKA
210 220 230 240 250
NFSIKIRREP RHLAISNMPL VKSVTIAEGL IEDHFDVTVR MSTYLVAFII
260 270 280 290 300
SDFESVSKMT KSGVKVSVYA VPDKINQADY ALDAAVTLLE FYEDYFSIPY
310 320 330 340 350
PLPKQDLAAI PDFQSGAMEN WGLTTYRESA LLFDTEKSSA SSKLSITMTV
360 370 380 390 400
SHELAHQWFG NLVTMEWWND LWLNEGFAKF MEFVSVSVTH PELKVEDYFF
410 420 430 440 450
GKCFDAMEVD ALNSSHPVST PVENPAEIRE MFDDVSYEKG ACILNMLRDY
460 470 480 490 500
LSADAFKSGI VQYLHKYSYK NTKNENLWNS MASICPTDGS QTMDGFCSRS
510 520 530 540 550
QHSSSTSHWH QESVDVKTMM NTWTLQKGFP LITITVRGRN IHMKQEHYMK
560 570 580 590 600
GSDSETGYLW HVPLTYITSK SDSVGRFLLK TKTDVLILPE AVEWIKFNVR
610 620 630 640 650
MSGYYIVHYE DDGWDSLTGL LKGAHTTISS NDRASLINNA FQLVSIGKLS
660 670 680 690 700
IEKALDLTLY LKHETEIMPV FQGLNELIPM YKLMEKRDMN EVETQFKAFL
710 720 730 740 750
IRLLRDLIDK QIWADEGSVS ERMLRSQLLL LACVRKYQPC VQKAEGYFRE
760 770 780 790 800
WRESNGNKSL PNDVTLAVFA VGAQNTEGWD FLYSKYQSSL SSTEKSQIEF
810 820 830 840 850
ALCTSQNKEK LQWLLDQSFK GDIIKTQDFP YILTLIAKNP VGYPLAWQFL
860 870 880 890 900
RENWNKLVQK FELGSSSIAH MVMGTTNQFS TRTRLEEVKG FFSSLKENGS
910 920 930
QLRCVQQTIE TIEENIRWMD KNFDKIRVWL QNEKLDLL
Length:938
Mass (Da):106,994
Last modified:July 11, 2012 - v1
Checksum:i519C57379B620853
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGTP01043296 Genomic DNA No translation available.
RefSeqiXP_005326202.1, XM_005326145.2

Genome annotation databases

EnsembliENSSTOT00000015276; ENSSTOP00000013687; ENSSTOG00000015275
GeneIDi101970056

Similar proteinsi

Entry informationi

Entry nameiI3MPH1_ICTTR
AccessioniPrimary (citable) accession number: I3MPH1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: March 28, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health