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Protein
Submitted name:

TNF receptor superfamily member 1A

Gene

TNFRSF1A

Organism
Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
TNF receptor superfamily member 1AImported
Gene namesi
Name:TNFRSF1AImported
OrganismiIctidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)Imported
Taxonomic identifieri43179 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciuromorphaSciuridaeXerinaeMarmotiniIctidomys
Proteomesi
  • UP000005215 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei212 – 234HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501166005922 – 437Sequence analysisAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 72PROSITE-ProRule annotation
Disulfide bondi84 ↔ 99PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Interactioni

Protein-protein interaction databases

STRINGi43179.ENSSTOP00000009024

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 81TNFR-CysInterPro annotationAdd BLAST39
Repeati43 – 81TNFR-CysPROSITE-ProRule annotationAdd BLAST39
Domaini83 – 125TNFR-CysInterPro annotationAdd BLAST43
Repeati83 – 125TNFR-CysPROSITE-ProRule annotationAdd BLAST43
Domaini126 – 166TNFR-CysInterPro annotationAdd BLAST41
Repeati126 – 166TNFR-CysPROSITE-ProRule annotationAdd BLAST41
Domaini338 – 423DeathInterPro annotationAdd BLAST86

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IXBX Eukaryota
ENOG4111YG2 LUCA
GeneTreeiENSGT00530000064001
InParanoidiI3MER3
OrthoDBiEOG091G07LE
TreeFamiTF333916

Family and domain databases

CDDicd08313 Death_TNFR1, 1 hit
cd10576 TNFRSF1A, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020419 TNFR_1A
IPR033994 TNFRSF1A_death
IPR033993 TNFRSF1A_N
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 2 hits
PRINTSiPR01918 TNFACTORR1A
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00208 TNFR, 3 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 3 hits

Sequencei

Sequence statusi: Complete.

I3MER3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPIVPGLL LPLVLLNVLV GIHPSGVIGL VAPLMDREKR DSLCPQGKYN
60 70 80 90 100
HPQNHSICCT KCHKGTYLYN DCPGPGLDTD CRECENGTFT ASENHLRQCL
110 120 130 140 150
SCSMCRKELS QVELSPCTVN QDTVCGCKKN QFRHYFSGKR FRCMTCSLCL
160 170 180 190 200
NGTVHIPCQE SQNTVCNCHS GFFPKENECV SCSECKNTPD CMNSCPPLSE
210 220 230 240 250
NVQNPLDSGT TVLLPLVILF GLCLFSLLLI GLMCRYPRWK SKLYSIVCEK
260 270 280 290 300
STPVKEGELE GIPTKHQDSG SSPFLSPTQP SCPTDWSNFR AVSSLREVTP
310 320 330 340 350
THQGADPILT MPVTSTPIVT QVQKWEDTAR MQRPDADPAT LYAVVDGVPP
360 370 380 390 400
SRWKELVRRL GLGEHEIERL ELQNGRCLRE AHYSMLAAWR QRTPRHKATL
410 420 430
DLLGQVLRDM DLLGCLEDIE EALRSSSSFS PTPSLLR
Length:437
Mass (Da):48,596
Last modified:November 22, 2017 - v2
Checksum:i50610CFF9AEBE39B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGTP01097484 Genomic DNA No translation available.
AGTP01097485 Genomic DNA No translation available.
RefSeqiXP_005338418.1, XM_005338361.2

Genome annotation databases

EnsembliENSSTOT00000010061; ENSSTOP00000009024; ENSSTOG00000010063
GeneIDi101965886

Similar proteinsi

Entry informationi

Entry nameiI3MER3_ICTTR
AccessioniPrimary (citable) accession number: I3MER3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: November 22, 2017
Last modified: May 23, 2018
This is version 39 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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