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Protein

Tyrosine-protein kinase receptor

Gene

NTRK2

Organism
Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:NTRK2Imported
OrganismiIctidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)Imported
Taxonomic identifieri43179 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciuromorphaSciuridaeXerinaeMarmotiniIctidomys
Proteomesi
  • UP000005215 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei430 – 453HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_501161986732 – 821Tyrosine-protein kinase receptorSequence analysisAdd BLAST790

Keywords - PTMi

Disulfide bondSAAS annotation, PhosphoproteinUniRule annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi43179.ENSSTOP00000008008.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini197 – 282Ig-likeInterPro annotationAdd BLAST86
Domaini537 – 806Protein kinaseInterPro annotationAdd BLAST270

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1026. Eukaryota.
ENOG410YGKQ. LUCA.
GeneTreeiENSGT00760000118818.
InParanoidiI3MCL6.
OMAiCSCEIMW.
OrthoDBiEOG091G01JY.
TreeFamiTF106465.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.80.10.10. 2 hits.
InterProiView protein in InterPro
IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom_sf.
IPR001611. Leu-rich_rpt.
IPR032675. LRR_dom_sf.
IPR000372. LRRNT.
IPR031635. NTRK_C2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR020455. Tyr_kin_neurotrophic_rcpt_2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
PfamiView protein in Pfam
PF07679. I-set. 2 hits.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF16920. TPKR_C2. 1 hit.
PRINTSiPR01939. NTKRECEPTOR.
PR01941. NTKRECEPTOR2.
PR00109. TYRKINASE.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.

Sequencei

Sequence statusi: Complete.

I3MCL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSWTRWHGP AMARFWGFCW LVVGFWRAAL ACPTSCKCTA SRIWCNDPSP
60 70 80 90 100
GIVAFPRLEP NSADPENITE IFIANQKRLE IINEDDVEAY VGLKNLTIVD
110 120 130 140 150
SGLKFVAYKA FMKNSNLQHI NFTRNKLTSL SRKHFRHLDL SELILVGNPF
160 170 180 190 200
TCSCDIMWIK TLQETKSSPE TQDLYCLNES SKNIPLANLQ IPNCGLPSAN
210 220 230 240 250
LAAPNLTVEE GKSITLSCIV AGDPLPNMYW DVGNLVSKHM NETSHTQGSL
260 270 280 290 300
RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH
310 320 330 340 350
WCIPFTVKGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN
360 370 380 390 400
PTHMNNGDYT LIAKNEYGKD ERQISAHFMG WPGIDDGANP NYPDVLYEDW
410 420 430 440 450
TATNDLGDAM NKSYEIPTTI VPGKTSQERL SVYAVVVIAS VVGFCLLVML
460 470 480 490 500
FLLKLARHSK FGMKGPASVI SNDDDSASPL HHISNGSNTP SSSEGGPDAV
510 520 530 540 550
IIGMTKIPVI ENPQYFGITN SQLKPDTFVQ HIKRHNIVLK RELGEGAFGK
560 570 580 590 600
VFLAECYNLC PEQDKILVAV KTLKDASDNA RKDFHREAEL LTNLQHEHIV
610 620 630 640 650
KFYGVCVEGD PLIMVFEYMK HGDLNKFLRA HGPDAVLMAE GNPPTELTQS
660 670 680 690 700
QMLHIAQQIA AGMVYLASQH FVHRDLATRN CLVGENLLVK IGDFGMSRDV
710 720 730 740 750
YSTDYYRVGG HTMLPIRWMP PESIMYRKFT TESDVWSLGV VLWEIFTYGK
760 770 780 790 800
QPWYQLSNNE VIECITQGRV LQRPRTCPQE VYELMLGCWQ REPHMRKNIK
810 820
GIHTLLQNLA KASPVYLDIL G
Length:821
Mass (Da):92,116
Last modified:November 22, 2017 - v2
Checksum:iA16DFB0301FD803D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGTP01092902 Genomic DNA. No translation available.
AGTP01092903 Genomic DNA. No translation available.
AGTP01092904 Genomic DNA. No translation available.
AGTP01092905 Genomic DNA. No translation available.
AGTP01092906 Genomic DNA. No translation available.
AGTP01092907 Genomic DNA. No translation available.
AGTP01092908 Genomic DNA. No translation available.
AGTP01092909 Genomic DNA. No translation available.
AGTP01092910 Genomic DNA. No translation available.
AGTP01092911 Genomic DNA. No translation available.
RefSeqiXP_005337487.1. XM_005337430.2.

Genome annotation databases

EnsembliENSSTOT00000008935; ENSSTOP00000008008; ENSSTOG00000008937.
GeneIDi101968856.

Similar proteinsi

Entry informationi

Entry nameiI3MCL6_ICTTR
AccessioniPrimary (citable) accession number: I3MCL6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: November 22, 2017
Last modified: December 20, 2017
This is version 47 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported