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Protein

Erythropoietin receptor

Gene

EPOR

Organism
Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Receptor for erythropoietin.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Erythropoietin receptorUniRule annotation
Short name:
EPO-RUniRule annotation
Gene namesi
Name:EPORImported
OrganismiIctidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)Imported
Taxonomic identifieri43179 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciuromorphaSciuridaeXerinaeMarmotiniIctidomys
Proteomesi
  • UP000005215 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondUniRule annotation

Interactioni

Subunit structurei

Forms homodimers on EPO stimulation.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi43179.ENSSTOP00000002673

Family & Domainsi

Sequence similaritiesi

Belongs to the type I cytokine receptor family. Type 1 subfamily.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IFGH Eukaryota
ENOG4111PGS LUCA
GeneTreeiENSGT00890000139540
InParanoidiI3M1H2
OrthoDBiEOG091G0AK8
TreeFamiTF336573

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR009167 Erythropoietin_rcpt
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR015152 Growth/epo_recpt_lig-bind
IPR013783 Ig-like_fold
IPR003528 Long_hematopoietin_rcpt_CS
PANTHERiPTHR23037:SF28 PTHR23037:SF28, 1 hit
PfamiView protein in Pfam
PF09067 EpoR_lig-bind, 1 hit
PIRSFiPIRSF001959 EPO_receptor, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS01352 HEMATOPO_REC_L_F1, 1 hit

Sequencei

Sequence statusi: Complete.

I3M1H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHLRAPLWP RVSPLFLLLA GAALAPPLNL PNPKLESKAA LLAARGSEDL
60 70 80 90 100
LCFTERLEDL VCFWEEAASS RIGSHNYSFF YQLEGEPRKP CHLHQEPTAR
110 120 130 140 150
GAVRFWCSLP TADTSSFVPL ELQVTVASSG TVRYHRTIHI NEVVLLDAPA
160 170 180 190 200
GLLARQAEEG GHVVLRWFPP PGAPMTTQIR YEVDVSAGHG AGGSQRVEIL
210 220 230 240 250
EGRTECVLSN LRGATRYTFA VRARMAEPSF GGFWSAWSEP VSLLTASDLD
260 270 280 290 300
PLILTLSLIL VLILLLLAVL ALLSHRRALK QKIWPGIPSP ESEFEGLFTT
310 320 330 340 350
HKGNFQLWLS QHDGCLWWNP CTPFTEDPPA RLEVLSERCW GVTQAVEPGA
360 370 380 390 400
DDKGPLLEPA GNEHTQDSYL VLDKWLLPQS PCSEDLSGPD GSVDTVAVDE
410 420 430 440 450
GSEASSCSSA LVLKPRQEGA SAASFEYTIL DPSSQLLRPR ALPPELPPTP
460 470 480 490 500
PHLKYLYLVV SDSGISTDYS SGDSQGAQGG SFDSPYSNLY ENSPVPTPEP

LSPSYVACS
Length:509
Mass (Da):55,352
Last modified:November 22, 2017 - v2
Checksum:iD2385BA78B10B293
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGTP01088415 Genomic DNA No translation available.
RefSeqiXP_005336221.1, XM_005336164.2

Genome annotation databases

EnsembliENSSTOT00000002991; ENSSTOP00000002673; ENSSTOG00000002992
GeneIDi101973855

Similar proteinsi

Entry informationi

Entry nameiI3M1H2_ICTTR
AccessioniPrimary (citable) accession number: I3M1H2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: November 22, 2017
Last modified: March 28, 2018
This is version 36 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health