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Protein

Phosphodiesterase

Gene

PDE1B

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

a divalent metal cationUniRule annotationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-SSC-111957. Cam-PDE 1 activation.
R-SSC-418457. cGMP effects.
R-SSC-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
PhosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
Gene namesi
Name:PDE1BImported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 5

PTM / Processingi

Proteomic databases

PaxDbiI3LNW1.

Expressioni

Gene expression databases

BgeeiENSSSCG00000029451.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000025786.

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3688. Eukaryota.
ENOG410XQDD. LUCA.
GeneTreeiENSGT00760000118889.
InParanoidiI3LNW1.
OMAiIVHAACH.
OrthoDBiEOG091G04C4.
TreeFamiTF314638.

Family and domain databases

CDDicd00077. HDc. 1 hit.
Gene3Di1.10.1300.10. 1 hit.
InterProiView protein in InterPro
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR036971. PDEase_catalytic_dom_sf.
IPR023174. PDEase_CS.
IPR013706. PDEase_N.
PfamiView protein in Pfam
PF00233. PDEase_I. 1 hit.
PF08499. PDEase_I_N. 1 hit.
PRINTSiPR00387. PDIESTERASE1.
SMARTiView protein in SMART
SM00471. HDc. 1 hit.
PROSITEiView protein in PROSITE
PS00126. PDEASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

I3LNW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPVPVQRS HLQGPILRLR YMVKQLENGE VNIEELKKNL EYTASLLEAV
60 70 80 90 100
YIDETRQILD TEDELQELRS DAVPSEVRDW LASTFTQQTR AKGRRAEEKP
110 120 130 140 150
KFRSIVHAVQ AGIFVERMFR RTYTSVGPTY STAVLNCLKN LDLWCFNVFS
160 170 180 190 200
LNRAADDHAL RTIVFELLTR HNLISRFKIP TVFLMTFLDA LETGYGKYKN
210 220 230 240 250
PYHNQIHAAD VTQTVHCFLL RTGMVHCLSE IEVLAIIFAA AIHDYEHTGT
260 270 280 290 300
TNSFHIQTKS ECAILYNDRS VLENHHISSV FRMMQDDEMN IFINLTKDEF
310 320 330 340 350
VELRALVIEM VLATDMSCHF QQVKSMKTAL QQLERIDKSK ALSLLLHAAD
360 370 380 390 400
ISHPTKQWSV HSRWTKALME EFFRQGDKEA ELGLPFSPLC DRTSTLVAQS
410 420 430 440 450
QIGFIDFIVE PTFSVLTDVA EKSVQPMGDE DSKSKNQPSF QWRQPSLDVE
460 470 480 490 500
VGDPNPDVVS FRSTWTKYIQ ENKQKWKERA ASGITNQMSI DELSPCEEEA
510
PACPAEDEHN QNGNLD
Length:516
Mass (Da):59,052
Last modified:November 22, 2017 - v2
Checksum:iD23AE764D60868B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000028 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSSSCT00000031749; ENSSSCP00000025786; ENSSSCG00000000297.

Similar proteinsi

Entry informationi

Entry nameiI3LNW1_PIG
AccessioniPrimary (citable) accession number: I3LNW1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: November 22, 2017
Last modified: November 22, 2017
This is version 35 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported