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Protein

Phosphodiesterase

Gene

PDE1B

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

a divalent metal cationUniRule annotationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-SSC-111957 Cam-PDE 1 activation
R-SSC-418457 cGMP effects
R-SSC-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
PhosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
Gene namesi
Name:PDE1BImported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 5

PTM / Processingi

Proteomic databases

PaxDbiI3LNW1
PRIDEiI3LNW1

Expressioni

Gene expression databases

BgeeiENSSSCG00000029451
ExpressionAtlasiI3LNW1 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000025786

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 483PDEaseInterPro annotationAdd BLAST358

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili19 – 39Sequence analysisAdd BLAST21
Coiled coili51 – 71Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3688 Eukaryota
ENOG410XQDD LUCA
GeneTreeiENSGT00760000118889
InParanoidiI3LNW1
OrthoDBiEOG091G04C4
TreeFamiTF314638

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
IPR013706 PDEase_N
PfamiView protein in Pfam
PF00233 PDEase_I, 1 hit
PF08499 PDEase_I_N, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

Sequencei

Sequence statusi: Complete.

I3LNW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPVPVQRS HLQGPILRLR YMVKQLENGE VNIEELKKNL EYTASLLEAV
60 70 80 90 100
YIDETRQILD TEDELQELRS DAVPSEVRDW LASTFTQQTR AKGRRAEEKP
110 120 130 140 150
KFRSIVHAVQ AGIFVERMFR RTYTSVGPTY STAVLNCLKN LDLWCFNVFS
160 170 180 190 200
LNRAADDHAL RTIVFELLTR HNLISRFKIP TVFLMTFLDA LETGYGKYKN
210 220 230 240 250
PYHNQIHAAD VTQTVHCFLL RTGMVHCLSE IEVLAIIFAA AIHDYEHTGT
260 270 280 290 300
TNSFHIQTKS ECAILYNDRS VLENHHISSV FRMMQDDEMN IFINLTKDEF
310 320 330 340 350
VELRALVIEM VLATDMSCHF QQVKSMKTAL QQLERIDKSK ALSLLLHAAD
360 370 380 390 400
ISHPTKQWSV HSRWTKALME EFFRQGDKEA ELGLPFSPLC DRTSTLVAQS
410 420 430 440 450
QIGFIDFIVE PTFSVLTDVA EKSVQPMGDE DSKSKNQPSF QWRQPSLDVE
460 470 480 490 500
VGDPNPDVVS FRSTWTKYIQ ENKQKWKERA ASGITNQMSI DELSPCEEEA
510
PACPAEDEHN QNGNLD
Length:516
Mass (Da):59,052
Last modified:November 22, 2017 - v2
Checksum:iD23AE764D60868B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000028 Genomic DNA No translation available.
RefSeqiXP_003481646.1, XM_003481598.3
UniGeneiSsc.31431

Genome annotation databases

EnsembliENSSSCT00000031749; ENSSSCP00000025786; ENSSSCG00000000297
GeneIDi100521662

Similar proteinsi

Entry informationi

Entry nameiI3LNW1_PIG
AccessioniPrimary (citable) accession number: I3LNW1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: November 22, 2017
Last modified: May 23, 2018
This is version 40 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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