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Protein

Coiled-coil domain-containing glutamate-rich protein 2

Gene

CCER2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing glutamate-rich protein 2
Gene namesi
Name:CCER2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000262484.1.
HGNCiHGNC:44662. CCER2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000262484.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000042555324 – 266Coiled-coil domain-containing glutamate-rich protein 2Add BLAST243

Proteomic databases

PaxDbiI3L3R5.
PRIDEiI3L3R5.

Expressioni

Tissue specificityi

Expressed at higher levels in fetal brain and skeletal muscle. Lower expression is detected in fetal kidney, liver, spleen, thymus, heart and lung.1 Publication

Gene expression databases

BgeeiENSG00000262484.
ExpressionAtlasiI3L3R5. baseline and differential.

Organism-specific databases

HPAiHPA069716.

Structurei

3D structure databases

ProteinModelPortaliI3L3R5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi99 – 265Glu-richAdd BLAST167
Compositional biasi214 – 220His-rich7

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JA8V. Eukaryota.
ENOG4111BDH. LUCA.
GeneTreeiENSGT00670000099437.
InParanoidiI3L3R5.
OMAiAERTHKS.
OrthoDBiEOG091G0UFY.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

I3L3R5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPRGPASEL LLLRLLLLGA ATAAPLAPRP SKEELTRCLA EVVTEVLTVG
60 70 80 90 100
QVQRGPCTAL LHKELCGTEP HGCASTEEKG LLLGDFKKQE AGKMRSSQEV
110 120 130 140 150
RDEEEEEVAE RTHKSEVQEQ AIRMQGHRQL HQEEDEEEEK EERKRGPMET
160 170 180 190 200
FEDLWQRHLE NGGDLQKRVA EKASDKETAQ FQAEEKGVRV LGGDRSLWQG
210 220 230 240 250
AERGGGERRE DLPHHHHHHH QPEAEPRQEK EEASEREEKE VEQLEHLRDE
260
LKKVTETLGE QLRREG
Length:266
Mass (Da):30,352
Last modified:July 11, 2012 - v1
Checksum:i24FABE1AD1EE487A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07915933E → D1 Publication1
Natural variantiVAR_07916039L → P1 Publication1
Natural variantiVAR_07916164E → D1 Publication1
Natural variantiVAR_07916276 – 80TEEKG → PS Found in patients with Moyamoya disease; unknown pathological significance. 1 Publication5
Natural variantiVAR_07916380G → V1 Publication1
Natural variantiVAR_079164160E → K1 Publication1
Natural variantiVAR_079165195R → C1 Publication1
Natural variantiVAR_079166218 – 220Missing Found in patients with Moyamoya disease; unknown pathological significance. 1 Publication3
Natural variantiVAR_079167220Missing 1 Publication1
Natural variantiVAR_079168224A → T1 Publication1
Natural variantiVAR_079169229Missing Found in patients with Moyamoya disease; unknown pathological significance. 1 Publication1
Natural variantiVAR_079170232E → A1 Publication1
Natural variantiVAR_079171242E → K Found in patients with Moyamoya disease; unknown pathological significance. 1 Publication1
Natural variantiVAR_079172249D → G1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011455 Genomic DNA. No translation available.
CCDSiCCDS58661.1.
RefSeqiNP_001230141.1. NM_001243212.1.
XP_011525520.1. XM_011527218.2.
UniGeneiHs.355357.

Genome annotation databases

EnsembliENST00000571838; ENSP00000460665; ENSG00000262484.
ENST00000635114; ENSP00000488939; ENSG00000283099.
GeneIDi643669.
KEGGihsa:643669.
UCSCiuc021uuj.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCER2_HUMAN
AccessioniPrimary (citable) accession number: I3L3R5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 19, 2014
Last sequence update: July 11, 2012
Last modified: November 22, 2017
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Despite its name, does not contain a real coiled coil domain region: predicted coiled coil regions are the result of the Glu-rich region.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot