ID   I3L3N5_HUMAN            Unreviewed;       208 AA.
AC   I3L3N5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   29-MAY-2024, entry version 64.
DE   SubName: Full=Platelet activating factor acetylhydrolase 1b regulatory subunit 1 {ECO:0000313|Ensembl:ENSP00000460591.1};
DE   Flags: Fragment;
GN   Name=PAFAH1B1 {ECO:0000313|Ensembl:ENSP00000460591.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000460591.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000460591.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0007829|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000460591.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2024) to UniProtKB.
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DR   EMBL; AC005696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC015799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; I3L3N5; -.
DR   SMR; I3L3N5; -.
DR   MassIVE; I3L3N5; -.
DR   PeptideAtlas; I3L3N5; -.
DR   ProteomicsDB; 47277; -.
DR   Antibodypedia; 3850; 341 antibodies from 40 providers.
DR   Ensembl; ENST00000574468.1; ENSP00000460591.1; ENSG00000007168.14.
DR   UCSC; uc059znz.1; human.
DR   HGNC; HGNC:8574; PAFAH1B1.
DR   VEuPathDB; HostDB:ENSG00000007168; -.
DR   GeneTree; ENSGT00940000155039; -.
DR   HOGENOM; CLU_000288_57_15_1; -.
DR   ChiTaRS; PAFAH1B1; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000007168; Expressed in sperm and 212 other cell types or tissues.
DR   ExpressionAtlas; I3L3N5; baseline and differential.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR44129; WD REPEAT-CONTAINING PROTEIN POP1; 1.
DR   PANTHER; PTHR44129:SF13; WD REPEAT-CONTAINING PROTEIN POP1; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 4.
DR   EPD; I3L3N5; -.
DR   MaxQB; I3L3N5; -.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:I3L3N5,
KW   ECO:0007829|MaxQB:I3L3N5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   REPEAT          1..19
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          20..61
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          62..103
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          132..173
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          174..208
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000460591.1"
SQ   SEQUENCE   208 AA;  23691 MW;  593CC346BAA286A2 CRC64;
     SADMTIKLWD FQGFECIRTM HGHDHNVSSV AIMPNGDHIV SASRDKTIKM WEVQTGYCVK
     TFTGHREWVR MVRPNQDGTL IASCSNDQTV RVWVVATKEC KAELREHEHV VECISWAPES
     SYSSISEATG SEVGHDNWVR GVLFHSGGKF ILSCADDKTL RVWDYKNKRC MKTLNAHEHF
     VTSLDFHKTA PYVVTGSVDQ TVKVWECR
//