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Protein

Fibroblast growth factor receptor

Gene

LOC100689850

Organism
Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei623Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:LOC100689850Imported
OrganismiOreochromis niloticus (Nile tilapia) (Tilapia nilotica)Imported
Taxonomic identifieri8128 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaCichlomorphaeCichliformesCichlidaeAfrican cichlidsPseudocrenilabrinaeOreochrominiOreochromis
Proteomesi
  • UP000005207 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_500367402139 – 818Fibroblast growth factor receptorSequence analysisAdd BLAST780

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi8128.ENSONIP00000015556

Structurei

3D structure databases

ProteinModelPortaliI3K361
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 133Ig-likeInterPro annotationAdd BLAST83
Domaini155 – 254Ig-likeInterPro annotationAdd BLAST100
Domaini263 – 365Ig-likeInterPro annotationAdd BLAST103
Domaini478 – 757Protein kinaseInterPro annotationAdd BLAST280

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
InParanoidiI3K361
OMAiQYSPTCQ
OrthoDBiEOG091G0CQZ
TreeFamiTF316307

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR016248 FGF_rcpt_fam
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF000628 FGFR, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

I3K361-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKLESGLA ALRLTSSSRG MTALWCSLWL SLLLPLCAVP ARLPTAQPTD
60 70 80 90 100
PVSSETAFLE DYVLGIGDTL EMSCDPEEQE DHSEPIVWFK DGAGLVPCNR
110 120 130 140 150
IRLGQRMLRI INVSYDDSGV YSCRLARSNA LLSNYTIRVT DSLSSGDDED
160 170 180 190 200
YDEDPEGAEA PYWTRPERMD KKLLAVPAAN TVKFRCAASG NPPPTIHWLK
210 220 230 240 250
NGKEFKGEQR MGGIKLRHQQ WSLVMESAVP SDRGNYTCVV QNKYGSISHT
260 270 280 290 300
YQLDVLERSP HRPILQAGLP ANQTVVVGSN VEFHCKVYSD AQPHIQWLKH
310 320 330 340 350
IEVNGSRFGH DGVPYVSVLK TAGINTTDKE LEVLLLTNVS FEDAGEYTCL
360 370 380 390 400
AGNSIGYSYH SAWLTVLPAV SPQKEDYYAD ILIYVTGCVL FILAVVIAIL
410 420 430 440 450
CRMRMTTQKT LPTPPVQKLS KFPLKRQQVS LDSNSSMNSN TPLVRIARLS
460 470 480 490 500
SSDGPTLANV SELELPSDPK WEFPRTRLTL GKPLGEGCFG QVVMAEAVGI
510 520 530 540 550
DKEKPNKSLT VAVKMLKDDA TDKDLSDLVS EMEMMKMIGK HKNIINLLGA
560 570 580 590 600
CTQDGPLYVL VEYASKGNLR EYLRARRPPG MDYSFDTCKI PDEQLTFKDL
610 620 630 640 650
VSCAYQVARG MEYLASQKCI HRDLAARNVL VTEDNVMKIA DFGLARDVHN
660 670 680 690 700
IDYYKKTTNG RLPVKWMAPE ALFDRVYTHQ SDVWSYGVLL WEIFTLGGSP
710 720 730 740 750
YPGIPVEELF KLLKEGHRMD KPANCTHELY MIMRECWHAV PSQRPTFRQL
760 770 780 790 800
VEDHDRILSM TSTDEYLDLS VPFEQYSPTC QDSNSTCSSG DDSVFAHDPL
810
PDEPCLPKQL PSNGVIRT
Length:818
Mass (Da):91,405
Last modified:July 11, 2012 - v1
Checksum:i14F437C9C76B8B48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AERX01018753 Genomic DNA No translation available.
AERX01018754 Genomic DNA No translation available.
AERX01018755 Genomic DNA No translation available.
AERX01018756 Genomic DNA No translation available.
RefSeqiXP_005453444.1, XM_005453387.3

Genome annotation databases

EnsembliENSONIT00000015569; ENSONIP00000015556; ENSONIG00000012350
GeneIDi100689850

Similar proteinsi

Entry informationi

Entry nameiI3K361_ORENI
AccessioniPrimary (citable) accession number: I3K361
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: March 28, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health