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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Bacillus sp. 5B6
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processAntibiotic resistanceUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
ORF Names:MY7_2787Imported
OrganismiBacillus sp. 5B6Imported
Taxonomic identifieri1127743 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000005799 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei89 – 112HelicalUniRule annotationAdd BLAST24
Transmembranei124 – 143HelicalUniRule annotationAdd BLAST20
Transmembranei195 – 216HelicalUniRule annotationAdd BLAST22
Transmembranei228 – 249HelicalUniRule annotationAdd BLAST22
Transmembranei255 – 275HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Membrane

Structurei

3D structure databases

SMRiI2HUL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiView protein in InterPro
IPR003824. UppP.
PANTHERiPTHR30622. PTHR30622. 1 hit.
PfamiView protein in Pfam
PF02673. BacA. 1 hit.
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

I2HUL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLWEMFTAA VLGIVEGLTE YAPVSSTGHM IIADDIWLKS GSLMNPEAAN
60 70 80 90 100
SFKVVIQLGS ILAVAIVFKD RILHLLGLKK NVTRDQQKGY RLTIAQIAVG
110 120 130 140 150
LVPAAVLGFL FEDFIDRYLF SVRTVAYGLI AGAVLMLIAD WINKRKETID
160 170 180 190 200
TVDRITYKQA FCVGLFQCLA LWPGFSRSGS TIAGGVIVGL NHRAAADFTF
210 220 230 240 250
IMAIPIMAGA SLLKLVKYWS SLSYDMIPFF LVGFICAFVV ALLVVKFFLR
260 270
LINRIKLVPF AIYRVILGII LIMLVR
Length:276
Mass (Da):30,532
Last modified:July 11, 2012 - v1
Checksum:iB4CC505EE2E13FCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJST01000001 Genomic DNA. Translation: EIF14424.1.
RefSeqiWP_007613337.1. NZ_AJST01000001.1.

Genome annotation databases

EnsemblBacteriaiEIF14424; EIF14424; MY7_2787.
PATRICifig|1127743.3.peg.2713.

Similar proteinsi

Entry informationi

Entry nameiI2HUL5_9BACI
AccessioniPrimary (citable) accession number: I2HUL5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 11, 2012
Last sequence update: July 11, 2012
Last modified: September 27, 2017
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported